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HSP90AA1 HSP90AA1 PLA2G6 PLA2G6 PIK3R1 PIK3R1 ARPC3 ARPC3 MYO1D MYO1D ACTR2 ACTR2 ARPC5 ARPC5 MYO1G MYO1G LOC111184480 LOC111184480 PLD2 PLD2 CRK CRK PAK1 PAK1 DSTN DSTN FMN2 FMN2 BAIAP2 BAIAP2 PLCG1 PLCG1 ACTR3 ACTR3 CYFIP1 CYFIP1 ARPC1B ARPC1B RAC1 RAC1 CFL1 CFL1 GRB2 GRB2 ACTG1 ACTG1 CYFIP2 CYFIP2 ARPC1A ARPC1A MAPK3 MAPK3 LIMK1 LIMK1 ELMO3 ELMO3 WIPF3 WIPF3 FMN1 FMN1 ELMO1 ELMO1 PLD3 PLD3 VAV3 VAV3 HSP90AB1 HSP90AB1 PIK3CB PIK3CB WASL WASL ARPC5L ARPC5L PLCG2 PLCG2 ABL1 ABL1 WASHC1 WASHC1 NCK1 NCK1 MYO10 MYO10 MYO5A MYO5A MYO5C MYO5C ABI1 ABI1 ACTR3B ACTR3B VAV2 VAV2 MYO1H MYO1H IGLL1 IGLL1 ACTBL2 ACTBL2 CDC42 CDC42 ACTL8 ACTL8 MAPK1 MAPK1 NF2 NF2 WASF1 WASF1 LOC111163081 LOC111163081 WASF2 WASF2 VAV1 VAV1 PIK3R2 PIK3R2 CD3G CD3G PTK2 PTK2 WIPF2 WIPF2 WAS WAS ARPC4 ARPC4 ACTB ACTB LOC111170420 LOC111170420 SYK SYK MYO1B MYO1B ELMO2 ELMO2 DOCK1 DOCK1 LOC111170413 LOC111170413 ABI2 ABI2 BRK1 BRK1 WIPF1 WIPF1 ARPC2 ARPC2 LOC111173517 LOC111173517 LOC111173521 LOC111173521 PLPP4 PLPP4 PIK3CA PIK3CA NCKAP1L NCKAP1L NCKAP1 NCKAP1 PLD1 PLD1 MYO1A MYO1A CFL2 CFL2 PRKCE PRKCE NCKIPSD NCKIPSD PLD4 PLD4 PRKCD PRKCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (835 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
MYO1DUnconventional myosin-Id isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1058 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
MYO1GUnconventional myosin-Ig isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
LOC111184480TCR gamma alternate reading frame protein. (343 aa)
PLD2Phospholipase. (933 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (782 aa)
WIPF3WAS/WASL-interacting protein family member 3. (465 aa)
FMN1Formin-1 isoform X2. (1200 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
PLD3Phospholipase D3. (490 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
WASHC1WASH complex subunit 1 isoform X1. (494 aa)
NCK1Cytoplasmic protein. (377 aa)
MYO10Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2055 aa)
MYO5AUnconventional myosin-Va isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa)
MYO5CUnconventional myosin-Vc; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
ABI1Abl interactor 1 isoform X1. (508 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
MYO1HUnconventional myosin-Ih isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1045 aa)
IGLL1Immunoglobulin lambda-like polypeptide 1 isoform X1. (212 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
NF2Merlin isoform X3. (619 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
LOC111163081LOW QUALITY PROTEIN: immunoglobulin lambda-1 light chain-like. (235 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
WIPF2WAS/WASL-interacting protein family member 2 isoform X1. (440 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC111170420Low affinity immunoglobulin gamma Fc region receptor II-like isoform X1. (144 aa)
SYKTyrosine-protein kinase. (626 aa)
MYO1BUnconventional myosin-Ib isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
ABI2Abl interactor 2 isoform X1. (544 aa)
BRK1Protein BRICK1. (75 aa)
WIPF1WAS/WASL-interacting protein family member 1 isoform X1. (494 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
LOC111173517Phospholipid phosphatase 5-like isoform X1. (272 aa)
LOC111173521Phospholipid phosphatase 5-like isoform X2. (269 aa)
PLPP4Phospholipid phosphatase 4 isoform X1. (271 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
NCKAP1Nck-associated protein 1 isoform X1. (1134 aa)
PLD1Phospholipase. (1151 aa)
MYO1ALOW QUALITY PROTEIN: unconventional myosin-Ia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1042 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
PRKCEProtein kinase C. (746 aa)
NCKIPSDNCK-interacting protein with SH3 domain. (714 aa)
PLD4Phospholipase D4. (487 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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