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PTK2 PTK2 WIPF2 WIPF2 WAS WAS ACTL8 ACTL8 CDC42 CDC42 ARPC4 ARPC4 ACTB ACTB LOC111170420 LOC111170420 SYK SYK MYO1B MYO1B ELMO2 ELMO2 DOCK1 DOCK1 IGLL1 IGLL1 ACTBL2 ACTBL2 PAK1 PAK1 CRK CRK LOC111184480 LOC111184480 LOC111170413 LOC111170413 BRK1 BRK1 MYO1G MYO1G CYFIP1 CYFIP1 ARPC1B ARPC1B RAC1 RAC1 CFL1 CFL1 GRB2 GRB2 ACTG1 ACTG1 CYFIP2 CYFIP2 ARPC1A ARPC1A MAPK3 MAPK3 LIMK1 LIMK1 ELMO3 ELMO3 WIPF3 WIPF3 FMN1 FMN1 ELMO1 ELMO1 VAV3 VAV3 HSP90AB1 HSP90AB1 ABI2 ABI2 MYO1H MYO1H ARPC5 ARPC5 ACTR2 ACTR2 MYO1D MYO1D ARPC3 ARPC3 WASL WASL ARPC5L ARPC5L ABL1 ABL1 WASHC1 WASHC1 NCK1 NCK1 MYO10 MYO10 MYO5A MYO5A MYO5C MYO5C ABI1 ABI1 ACTR3B ACTR3B VAV2 VAV2 HSP90AA1 HSP90AA1 NCKIPSD NCKIPSD CFL2 CFL2 MYO1A MYO1A NCKAP1 NCKAP1 NCKAP1L NCKAP1L ARPC2 ARPC2 WIPF1 WIPF1 ACTR3 ACTR3 BAIAP2 BAIAP2 FMN2 FMN2 DSTN DSTN MAPK1 MAPK1 NF2 NF2 WASF1 WASF1 LOC111163081 LOC111163081 WASF2 WASF2 VAV1 VAV1 CD3G CD3G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
WIPF2WAS/WASL-interacting protein family member 2 isoform X1. (440 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC111170420Low affinity immunoglobulin gamma Fc region receptor II-like isoform X1. (144 aa)
SYKTyrosine-protein kinase. (626 aa)
MYO1BUnconventional myosin-Ib isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
IGLL1Immunoglobulin lambda-like polypeptide 1 isoform X1. (212 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
LOC111184480TCR gamma alternate reading frame protein. (343 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
BRK1Protein BRICK1. (75 aa)
MYO1GUnconventional myosin-Ig isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (782 aa)
WIPF3WAS/WASL-interacting protein family member 3. (465 aa)
FMN1Formin-1 isoform X2. (1200 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
ABI2Abl interactor 2 isoform X1. (544 aa)
MYO1HUnconventional myosin-Ih isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1045 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
MYO1DUnconventional myosin-Id isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1058 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
WASHC1WASH complex subunit 1 isoform X1. (494 aa)
NCK1Cytoplasmic protein. (377 aa)
MYO10Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2055 aa)
MYO5AUnconventional myosin-Va isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa)
MYO5CUnconventional myosin-Vc; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
ABI1Abl interactor 1 isoform X1. (508 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
NCKIPSDNCK-interacting protein with SH3 domain. (714 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
MYO1ALOW QUALITY PROTEIN: unconventional myosin-Ia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1042 aa)
NCKAP1Nck-associated protein 1 isoform X1. (1134 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
WIPF1WAS/WASL-interacting protein family member 1 isoform X1. (494 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
NF2Merlin isoform X3. (619 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
LOC111163081LOW QUALITY PROTEIN: immunoglobulin lambda-1 light chain-like. (235 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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