STRINGSTRING
TGFB1 TGFB1 ITGB8 ITGB8 FBN1 FBN1 PPP1R15A PPP1R15A ITGB3 ITGB3 SMAD7 SMAD7 SMURF2 SMURF2 FKBP1A FKBP1A LTBP4 LTBP4 LDLRAD4 LDLRAD4 MTMR4 MTMR4 NEDD8 NEDD8 TGFBR2 TGFBR2 KXD1 KXD1 CBL CBL FURIN FURIN PCSK4 PCSK4 UBE2M UBE2M ITGB5 ITGB5 ITGAV ITGAV ITGB6 ITGB6 LTBP1 LTBP1 TGFB2 TGFB2 ZFYVE9 ZFYVE9 ITGA8 ITGA8 TGFB3 TGFB3 BAMBI BAMBI STRAP STRAP SMAD3 SMAD3 LTBP3 LTBP3 RPS27A RPS27A STUB1 STUB1 PMEPA1 PMEPA1 TGFBR1 TGFBR1 SMAD2 SMAD2 SMAD4 SMAD4 ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
FBN1Fibrillin-1 isoform X1. (2871 aa)
PPP1R15ALOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 15A. (569 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1628 aa)
LDLRAD4LOW QUALITY PROTEIN: low-density lipoprotein receptor class A domain-containing protein 4. (322 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1211 aa)
NEDD8NEDD8 isoform X1. (98 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (779 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1711 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1062 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
STRAPSerine-threonine kinase receptor-associated protein isoform X1. (350 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (303 aa)
PMEPA1Protein TMEPAI. (290 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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