STRINGSTRING
TGFB1 TGFB1 TGFBR2 TGFBR2 ARHGEF18 ARHGEF18 CGN CGN F11R F11R PARD3B PARD3B RHOA RHOA PARD3 PARD3 PARD6A PARD6A SMURF1 SMURF1 LOC111185603 LOC111185603 RPS27A RPS27A PRKCZ PRKCZ TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X1. (1420 aa)
CGNCingulin isoform X1. (1194 aa)
F11RJunctional adhesion molecule A. (299 aa)
PARD3BPartitioning defective 3 homolog B isoform X1. (1202 aa)
RHOATransforming protein RhoA. (193 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
LOC111185603Basic proline-rich protein-like. (161 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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