STRINGSTRING
GRIN1 GRIN1 EPHA1 EPHA1 PSEN1 PSEN1 LOC111178990 LOC111178990 PSEN2 PSEN2 GRIN2B GRIN2B EPHA3 EPHA3 EFNB2 EFNB2 ACTR3B ACTR3B VAV2 VAV2 LOC111175797 LOC111175797 LOC111162707 LOC111162707 MYL12B MYL12B ACTBL2 ACTBL2 CDC42 CDC42 EPHA8 EPHA8 ACTL8 ACTL8 EPHB2 EPHB2 ITSN1 ITSN1 FYN FYN ROCK2 ROCK2 SDCBP SDCBP LOC111165935 LOC111165935 EPHA7 EPHA7 EFNA3 EFNA3 LYN LYN MMP2 MMP2 PTK2 PTK2 EFNA4 EFNA4 PAK3 PAK3 EPHA5 EPHA5 NCSTN NCSTN LOC111169792 LOC111169792 EFNA1 EFNA1 ARPC4 ARPC4 ACTB ACTB HRAS HRAS LOC111167809 LOC111167809 MMP9 MMP9 EFNA2 EFNA2 PAK2 PAK2 ARPC2 ARPC2 EPHB3 EPHB3 FNDC3B FNDC3B EPHA4 EPHA4 NGEF NGEF CFL2 CFL2 TIAM1 TIAM1 EPHA10 EPHA10 RHOA RHOA FNDC3A FNDC3A ARHGEF7 ARHGEF7 APH1B APH1B ARPC5L ARPC5L WASL WASL EPHB6 EPHB6 EPHB1 EPHB1 SDC2 SDC2 VAV3 VAV3 FMN1 FMN1 YES1 YES1 ROCK1 ROCK1 ARPC1A ARPC1A EPHB4 EPHB4 PSENEN PSENEN ACTG1 ACTG1 CFL1 CFL1 RAC1 RAC1 ARPC1B ARPC1B ACTR3 ACTR3 EFNA5 EFNA5 RASA1 RASA1 FMN2 FMN2 SRC SRC DSTN DSTN SDCBP2 SDCBP2 PAK1 PAK1 EFNB3 EFNB3 ARHGEF28 ARHGEF28 ARPC5 ARPC5 ACTR2 ACTR2 GIT1 GIT1 ARPC3 ARPC3 LOC111186089 LOC111186089 EPHA2 EPHA2 NCK2 NCK2 LOC111187154 LOC111187154
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (981 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
LOC111178990Ephrin type-A receptor 6 isoform X1. (774 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (512 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
EPHA3Ephrin type-A receptor 3. (984 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
LOC111175797Ephrin type-A receptor 6-like. (409 aa)
LOC111162707LIM domain kinase 2 isoform X1. (837 aa)
MYL12BMyosin regulatory light chain 12B. (172 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
FYNTyrosine-protein kinase. (537 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
SDCBPSyntenin-1 isoform X3. (301 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa)
LYNTyrosine-protein kinase. (518 aa)
MMP272 kDa type IV collagenase. (661 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
EFNA4ephrin-A4 isoform X1; Belongs to the ephrin family. (204 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1037 aa)
NCSTNNicastrin. (709 aa)
LOC111169792Uncharacterized protein LOC111169792. (306 aa)
EFNA1ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ACTBActin, cytoplasmic 1. (375 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
EFNA2ephrin-A2; Belongs to the ephrin family. (214 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
NGEFEphexin-1 isoform X1. (616 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
EPHA10Ephrin type-A receptor 10 isoform X1. (1017 aa)
RHOATransforming protein RhoA. (193 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
EPHB1Ephrin type-B receptor 1 isoform X1. (984 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
FMN1Formin-1 isoform X2. (1200 aa)
YES1Tyrosine-protein kinase. (541 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
PSENENGamma-secretase subunit PEN-2 isoform X1. (101 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
SRCTyrosine-protein kinase. (562 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
SDCBP2Syntenin-2 isoform X1. (291 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform X1. (1759 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC111186089LOW QUALITY PROTEIN: syntenin-1-like. (307 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
NCK2Cytoplasmic protein. (376 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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