STRINGSTRING
SDCBP2 SDCBP2 DSTN DSTN SRC SRC FMN2 FMN2 RASA1 RASA1 EFNA5 EFNA5 ACTR3 ACTR3 ARPC1B ARPC1B RAC1 RAC1 CFL1 CFL1 ACTG1 ACTG1 PSENEN PSENEN EPHB4 EPHB4 ARPC1A ARPC1A ROCK1 ROCK1 YES1 YES1 FMN1 FMN1 VAV3 VAV3 SDC2 SDC2 EPHB1 EPHB1 EPHB6 EPHB6 WASL WASL ARPC5L ARPC5L APH1B APH1B GRIN1 GRIN1 EPHA1 EPHA1 PSEN1 PSEN1 LOC111178990 LOC111178990 PSEN2 PSEN2 GRIN2B GRIN2B EPHA3 EPHA3 EFNB2 EFNB2 ACTR3B ACTR3B VAV2 VAV2 LOC111175797 LOC111175797 ARHGEF7 ARHGEF7 FNDC3A FNDC3A RHOA RHOA EPHA10 EPHA10 TIAM1 TIAM1 CFL2 CFL2 NGEF NGEF EPHA4 EPHA4 FNDC3B FNDC3B EPHB3 EPHB3 ARPC2 ARPC2 PAK2 PAK2 EFNA2 EFNA2 MMP9 MMP9 LOC111167809 LOC111167809 HRAS HRAS ACTB ACTB ARPC4 ARPC4 EFNA1 EFNA1 LOC111169792 LOC111169792 NCSTN NCSTN EPHA5 EPHA5 PAK3 PAK3 EFNA4 EFNA4 PTK2 PTK2 MMP2 MMP2 LYN LYN EFNA3 EFNA3 EPHA7 EPHA7 LOC111165935 LOC111165935 SDCBP SDCBP ROCK2 ROCK2 FYN FYN ITSN1 ITSN1 EPHB2 EPHB2 ACTL8 ACTL8 EPHA8 EPHA8 CDC42 CDC42 ACTBL2 ACTBL2 MYL12B MYL12B LOC111162707 LOC111162707 NCK2 NCK2 LOC111187154 LOC111187154 EPHA2 EPHA2 LOC111186089 LOC111186089 ARPC3 ARPC3 GIT1 GIT1 ACTR2 ACTR2 ARPC5 ARPC5 ARHGEF28 ARHGEF28 EFNB3 EFNB3 PAK1 PAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SDCBP2Syntenin-2 isoform X1. (291 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
SRCTyrosine-protein kinase. (562 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PSENENGamma-secretase subunit PEN-2 isoform X1. (101 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
YES1Tyrosine-protein kinase. (541 aa)
FMN1Formin-1 isoform X2. (1200 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
EPHB1Ephrin type-B receptor 1 isoform X1. (984 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (981 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
LOC111178990Ephrin type-A receptor 6 isoform X1. (774 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (512 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
EPHA3Ephrin type-A receptor 3. (984 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
LOC111175797Ephrin type-A receptor 6-like. (409 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
RHOATransforming protein RhoA. (193 aa)
EPHA10Ephrin type-A receptor 10 isoform X1. (1017 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
NGEFEphexin-1 isoform X1. (616 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
EFNA2ephrin-A2; Belongs to the ephrin family. (214 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
HRASGTPase HRas isoform X1. (189 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
EFNA1ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa)
LOC111169792Uncharacterized protein LOC111169792. (306 aa)
NCSTNNicastrin. (709 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1037 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
EFNA4ephrin-A4 isoform X1; Belongs to the ephrin family. (204 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
MMP272 kDa type IV collagenase. (661 aa)
LYNTyrosine-protein kinase. (518 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
SDCBPSyntenin-1 isoform X3. (301 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
FYNTyrosine-protein kinase. (537 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
MYL12BMyosin regulatory light chain 12B. (172 aa)
LOC111162707LIM domain kinase 2 isoform X1. (837 aa)
NCK2Cytoplasmic protein. (376 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
LOC111186089LOW QUALITY PROTEIN: syntenin-1-like. (307 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform X1. (1759 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.