49 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (954 aa)
	PSME2	Proteasome activator complex subunit 2. (239 aa)
	PSME1	Proteasome activator complex subunit 1. (249 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMC2	26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	PSMA1	Proteasome subunit alpha type. (263 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
	PSMC6	26S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMD6	26S proteasome non-ATPase regulatory subunit 6 isoform X1. (452 aa)
	PSMC1	26S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMB11	Proteasome subunit beta. (291 aa)
	RFWD2	E3 ubiquitin-protein ligase RFWD2 isoform X1. (735 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
	LOC111166275	Proteasome activator complex subunit 3-like. (165 aa)
	KXD1	kxDL motif-containing protein 1 isoform X1. (196 aa)
	PSMD3	26S proteasome non-ATPase regulatory subunit 3. (534 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	PSMD5	26S proteasome non-ATPase regulatory subunit 5. (504 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMD7	26S proteasome non-ATPase regulatory subunit 7. (322 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMC4	26S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	PSMD8	26S proteasome non-ATPase regulatory subunit 8. (351 aa)
	PSMA8	Proteasome subunit alpha type. (269 aa)
	PSMC5	26S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
	PSMC3	26S proteasome regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (423 aa)
	PSMD12	26S proteasome non-ATPase regulatory subunit 12. (456 aa)
	PSMF1	Proteasome inhibitor PI31 subunit isoform X1. (270 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	PSMD11	26S proteasome non-ATPase regulatory subunit 11. (422 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSME4	LOW QUALITY PROTEIN: proteasome activator complex subunit 4. (1845 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	PSMD9	26S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
	LOC111166421	Proteasome activator complex subunit 3. (254 aa)
	PSMD13	26S proteasome non-ATPase regulatory subunit 13. (376 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	PSMD4	26S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	RFWD2	A0A2Y9M6F8	A0A2Y9LSA3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase RFWD2 isoform X1.	0.813
ATM	RPS27A	A0A2Y9M6F8	A0A2Y9Q1L7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ubiquitin-40S ribosomal protein S27a.	0.586
ATM	TP53	A0A2Y9M6F8	Q8SPZ3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.998
KXD1	PSMD12	A0A2Y9LWQ6	A0A2Y9PQ26	kxDL motif-containing protein 1 isoform X1.	26S proteasome non-ATPase regulatory subunit 12.	0.409
KXD1	RPS27A	A0A2Y9LWQ6	A0A2Y9Q1L7	kxDL motif-containing protein 1 isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.770
LOC111166275	LOC111166421	A0A2Y9LVT1	A0A2Y9M8X0	Proteasome activator complex subunit 3-like.	Proteasome activator complex subunit 3.	0.901
LOC111166275	PSMA1	A0A2Y9LVT1	A0A2Y9LP04	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.807
LOC111166275	PSMA2	A0A2Y9LVT1	A0A2Y9PZL8	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.826
LOC111166275	PSMA3	A0A2Y9LVT1	A0A2Y9MWF3	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.847
LOC111166275	PSMA4	A0A2Y9LVT1	A0A2Y9P184	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.786
LOC111166275	PSMA5	A0A2Y9LVT1	A0A2Y9NY35	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.852
LOC111166275	PSMA6	A0A2Y9LVT1	A0A2Y9MVK9	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.791
LOC111166275	PSMA7	A0A2Y9LVT1	A0A2Y9QD88	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.835
LOC111166275	PSMA8	A0A2Y9LVT1	A0A2Y9PBF0	Proteasome activator complex subunit 3-like.	Proteasome subunit alpha type.	0.808
LOC111166275	PSMB1	A0A2Y9LVT1	A0A2Y9M5C2	Proteasome activator complex subunit 3-like.	Proteasome subunit beta.	0.763
LOC111166275	PSMB10	A0A2Y9LVT1	A0A2Y9P6Z5	Proteasome activator complex subunit 3-like.	Proteasome subunit beta.	0.725
LOC111166275	PSMB11	A0A2Y9LVT1	A0A2Y9LQI3	Proteasome activator complex subunit 3-like.	Proteasome subunit beta.	0.579
LOC111166275	PSMB2	A0A2Y9LVT1	A0A2Y9NDA8	Proteasome activator complex subunit 3-like.	Proteasome subunit beta.	0.856
LOC111166275	PSMB3	A0A2Y9LVT1	A0A2Y9LYB3	Proteasome activator complex subunit 3-like.	Proteasome subunit beta.	0.803
LOC111166275	PSMB4	A0A2Y9LVT1	A0A2Y9MFS4	Proteasome activator complex subunit 3-like.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.808