18 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111178927	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111178929	HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1. (231 aa)
	LOC111178925	boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2. (276 aa)
	LOC111178931	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
	LOC111178928	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	CSK	Tyrosine-protein kinase. (528 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2 isoform X1. (337 aa)
	CD274	Programmed cell death 1 ligand 1 isoform X2. (312 aa)
	PDCD1	Programmed cell death protein 1 isoform X1. (288 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain. (197 aa)
	CD3G	T-cell surface glycoprotein CD3 gamma chain. (178 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD274	A0A2Y9MEJ4	A0A2Y9N8R8	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Programmed cell death 1 ligand 1 isoform X2.	0.547
CD247	CD3D	A0A2Y9MEJ4	A0A2Y9LYT5	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 delta chain.	0.997
CD247	CD3E	A0A2Y9MEJ4	A0A2Y9LZK5	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 epsilon chain.	0.998
CD247	CD3G	A0A2Y9MEJ4	A0A2Y9LYW5	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 gamma chain.	0.999
CD247	CD4	A0A2Y9MEJ4	Q9XS78	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.434
CD247	CSK	A0A2Y9MEJ4	A0A2Y9NNZ0	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein kinase.	0.647
CD247	LCK	A0A2Y9MEJ4	A0A2Y9NNB7	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein kinase.	0.766
CD247	LOC111178925	A0A2Y9MEJ4	A0A2Y9NUY5	T-cell surface glycoprotein CD3 zeta chain isoform X1.	boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2.	0.937
CD247	LOC111178927	A0A2Y9MEJ4	A0A2Y9P6P1	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family.	0.955
CD247	LOC111178928	A0A2Y9MEJ4	A0A2Y9NRY9	T-cell surface glycoprotein CD3 zeta chain isoform X1.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.937
CD247	LOC111178929	A0A2Y9MEJ4	A0A2Y9NUZ1	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1.	0.937
CD247	LOC111178931	A0A2Y9MEJ4	A0A2Y9NRZ3	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.946
CD247	LOC111187198	A0A2Y9MEJ4	A0A2Y9QG58	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.511
CD247	PDCD1	A0A2Y9MEJ4	A0A2Y9MSN4	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Programmed cell death protein 1 isoform X1.	0.614
CD247	PDCD1LG2	A0A2Y9MEJ4	A0A2Y9ND36	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Programmed cell death 1 ligand 2 isoform X1.	0.572
CD247	PTPN11	A0A2Y9MEJ4	A0A2Y9QEG1	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.600
CD247	PTPN6	A0A2Y9MEJ4	A0A2Y9NJV6	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.959
CD274	CD247	A0A2Y9N8R8	A0A2Y9MEJ4	Programmed cell death 1 ligand 1 isoform X2.	T-cell surface glycoprotein CD3 zeta chain isoform X1.	0.547
CD274	CD3D	A0A2Y9N8R8	A0A2Y9LYT5	Programmed cell death 1 ligand 1 isoform X2.	T-cell surface glycoprotein CD3 delta chain.	0.515
CD274	CD3E	A0A2Y9N8R8	A0A2Y9LZK5	Programmed cell death 1 ligand 1 isoform X2.	T-cell surface glycoprotein CD3 epsilon chain.	0.700