STRINGSTRING
LOC111165935 LOC111165935 ARPC2 ARPC2 PTK2 PTK2 ARPC4 ARPC4 ACTB ACTB HRAS HRAS LOC111167809 LOC111167809 LOC111162707 LOC111162707 ACTBL2 ACTBL2 CDC42 CDC42 ACTL8 ACTL8 EPHB2 EPHB2 ITSN1 ITSN1 ROCK2 ROCK2 EPHB3 EPHB3 FNDC3B FNDC3B CFL2 CFL2 TIAM1 TIAM1 RHOA RHOA FNDC3A FNDC3A ACTR3B ACTR3B EFNB2 EFNB2 GRIN2B GRIN2B GRIN1 GRIN1 ARPC5L ARPC5L ARPC3 ARPC3 ACTR2 ACTR2 ARPC5 ARPC5 WASL WASL EPHB6 EPHB6 EPHB1 EPHB1 SDC2 SDC2 FMN1 FMN1 ROCK1 ROCK1 ARPC1A ARPC1A ARHGEF28 ARHGEF28 EFNB3 EFNB3 PAK1 PAK1 DSTN DSTN FMN2 FMN2 RASA1 RASA1 ACTR3 ACTR3 ARPC1B ARPC1B RAC1 RAC1 CFL1 CFL1 ACTG1 ACTG1 EPHB4 EPHB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111165935Ras-like protein isoform X1. (285 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ACTBActin, cytoplasmic 1. (375 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
LOC111162707LIM domain kinase 2 isoform X1. (837 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
RHOATransforming protein RhoA. (193 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
EPHB1Ephrin type-B receptor 1 isoform X1. (984 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
FMN1Formin-1 isoform X2. (1200 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform X1. (1759 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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