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PRKG2 PRKG2 ATP2B1 ATP2B1 GNG4 GNG4 FGR FGR PAFAH2 PAFAH2 GNGT2 GNGT2 PDE1A PDE1A GNG7 GNG7 PDE11A PDE11A SLC8A3 SLC8A3 ATP2B3 ATP2B3 PPP2CB PPP2CB ITPR1 ITPR1 GNB4 GNB4 PPP2R5E PPP2R5E PRKG1 PRKG1 PDE1B PDE1B PPP2R5C PPP2R5C GNG2 GNG2 APOB APOB NOS3 NOS3 ITPR2 ITPR2 GNB3 GNB3 PTPN6 PTPN6 SLC8A1 SLC8A1 LOC111176690 LOC111176690 LRP8 LRP8 GNB5 GNB5 MAPK14 MAPK14 CALM1 CALM1 LOC111177332 LOC111177332 PPP2R5D PPP2R5D ITPR3 ITPR3 GNG5 GNG5 GNG12 GNG12 GNG11 GNG11 PTGIR PTGIR PPP2R1A PPP2R1A SRI SRI SLC8A2 SLC8A2 GNB2 GNB2 GNG8 GNG8 GNGT1 GNGT1 LOC111182630 LOC111182630 PPP2CA PPP2CA MILR1 MILR1 PPP2R5B PPP2R5B ORAI3 ORAI3 ORAI2 ORAI2 TRPC7 TRPC7 ATP2A1 ATP2A1 PECAM1 PECAM1 REEP2 REEP2 PPP2R5A PPP2R5A PDE2A PDE2A GNG13 GNG13 ATP2B4 ATP2B4 GNG3 GNG3 P2RX3 P2RX3 P2RX1 P2RX1 PDE5A PDE5A PLA2G4A PLA2G4A ATP2A3 ATP2A3 LOC111185989 LOC111185989 P2RX7 P2RX7 P2RX2 P2RX2 P2RX4 P2RX4 ORAI1 ORAI1 TRPC3 TRPC3 ATP2A2 ATP2A2 NOS1 NOS1 PTPN11 PTPN11 GNB1 GNB1 LOC111187198 LOC111187198 PDE9A PDE9A P2RX6 P2RX6 LOC111163515 LOC111163515 MRVI1 MRVI1 PDE10A PDE10A PPP2R1B PPP2R1B ATP2B2 ATP2B2 REEP4 REEP4 TRPC6 TRPC6 LOC111170125 LOC111170125 REEP3 REEP3 LOC111170557 LOC111170557
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKG2cGMP-dependent protein kinase. (792 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
FGRTyrosine-protein kinase. (526 aa)
PAFAH2Platelet-activating factor acetylhydrolase. (392 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PDE1APhosphodiesterase. (536 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PDE11APhosphodiesterase. (930 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1248 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PDE1BPhosphodiesterase. (542 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (578 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
APOBApolipoprotein B-100. (4566 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2. (299 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X7; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1004 aa)
LOC111176690Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
LRP8Low-density lipoprotein receptor-related protein 8 isoform X1. (996 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
LOC111177332Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
SRISorcin. (198 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MILR1Allergin-1 isoform X1. (318 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
ORAI3Protein orai-3. (306 aa)
ORAI2Protein orai-2. (254 aa)
TRPC7Short transient receptor potential channel 7 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
REEP2Receptor expression-enhancing protein. (254 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PDE2APhosphodiesterase. (971 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PDE5APhosphodiesterase. (865 aa)
PLA2G4APhospholipase A2. (749 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (479 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
ORAI1Calcium release-activated calcium channel protein 1. (410 aa)
TRPC3LOW QUALITY PROTEIN: short transient receptor potential channel 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1461 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PDE9APhosphodiesterase. (529 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (393 aa)
LOC111163515Uncharacterized protein LOC111163515. (1806 aa)
MRVI1Protein MRVI1 isoform X1. (902 aa)
PDE10APhosphodiesterase. (943 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1320 aa)
REEP4Receptor expression-enhancing protein. (257 aa)
TRPC6Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
LOC111170125Myosin light chain 1, skeletal muscle isoform-like isoform X1; Belongs to the calmodulin family. (304 aa)
REEP3Receptor expression-enhancing protein. (258 aa)
LOC111170557LOW QUALITY PROTEIN: short transient receptor potential channel 2-like; Belongs to the transient receptor (TC 1.A.4) family. (902 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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