45 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL2RA	Interleukin-2 receptor subunit alpha. (275 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	IL2RB	Interleukin-2 receptor subunit beta isoform X1. (595 aa)
	GAB2	GRB2-associated-binding protein 2 isoform X1. (678 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	CSF2RB	Cytokine receptor common subunit beta. (902 aa)
	CRK	Adapter molecule crk isoform X1. (304 aa)
	HCK	Tyrosine-protein kinase. (506 aa)
	LOC111184310	Tyrosine-protein kinase. (369 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (144 aa)
	YES1	Tyrosine-protein kinase. (541 aa)
	YWHAZ	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	IL5RA	Interleukin-5 receptor subunit alpha isoform X1. (417 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
	INPPL1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1264 aa)
	IL3RA	Interleukin-3 receptor subunit alpha isoform X1. (473 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	TEC	Tyrosine-protein kinase. (658 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	CSF2RA	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1. (430 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	CBL	E3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
	LOC111166483	Signal transducer and activator of transcription. (787 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	VAV1	Proto-oncogene vav isoform X1. (845 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	CRKL	Crk-like protein. (303 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	CRK	A0A2Y9M339	A0A2Y9PWG4	E3 ubiquitin-protein ligase CBL isoform X1.	Adapter molecule crk isoform X1.	0.993
CBL	CRKL	A0A2Y9M339	A0A2Y9LB74	E3 ubiquitin-protein ligase CBL isoform X1.	Crk-like protein.	0.998
CBL	FYN	A0A2Y9M339	A0A2Y9LLH3	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.876
CBL	GRB2	A0A2Y9M339	A0A2Y9PJ90	E3 ubiquitin-protein ligase CBL isoform X1.	Growth factor receptor-bound protein 2.	0.997
CBL	HCK	A0A2Y9M339	A0A2Y9PT83	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.683
CBL	INPP5D	A0A2Y9M339	A0A2Y9MYB1	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1.	0.424
CBL	INPPL1	A0A2Y9M339	A0A2Y9MR36	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1.	0.689
CBL	JAK1	A0A2Y9M339	A0A2Y9P436	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.588
CBL	JAK2	A0A2Y9M339	A0A2Y9N3T7	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.601
CBL	JAK3	A0A2Y9M339	A0A2Y9M4G7	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.444
CBL	LOC111184310	A0A2Y9M339	A0A2Y9PNF5	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.683
CBL	LOC111187198	A0A2Y9M339	A0A2Y9QG58	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.614
CBL	LYN	A0A2Y9M339	A0A2Y9LZZ2	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein kinase.	0.915
CBL	PIK3CA	A0A2Y9M339	A0A2Y9MZW2	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.867
CBL	PIK3CB	A0A2Y9M339	A0A2Y9NZC3	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.867
CBL	PIK3CD	A0A2Y9M339	A0A2Y9QGK3	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.841
CBL	PIK3R1	A0A2Y9M339	A0A2Y9Q8T5	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.987
CBL	PIK3R2	A0A2Y9M339	A0A2Y9LXY5	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.919
CBL	PIK3R3	A0A2Y9M339	A0A2Y9NAQ0	E3 ubiquitin-protein ligase CBL isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	0.895
CBL	PTPN11	A0A2Y9M339	A0A2Y9QEG1	E3 ubiquitin-protein ligase CBL isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.707