STRINGSTRING
CD14 CD14 TNFSF10 TNFSF10 APPL1 APPL1 LOC111173902 LOC111173902 TRAF2 TRAF2 DAPK2 DAPK2 IGDCC4 IGDCC4 TRADD TRADD RIPK1 RIPK1 APPL2 APPL2 LOC111185436 LOC111185436 LOC111185435 LOC111185435 CASP9 CASP9 LY96 LY96 LOC111184077 LOC111184077 TICAM2 TICAM2 CASP3 CASP3 FADD FADD UNC5B UNC5B DAPK3 DAPK3 DAPK1 DAPK1 FASLG FASLG CFLAR CFLAR TMEM198 TMEM198 CASP8 CASP8 FAS FAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (288 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
LOC111173902Transmembrane protein 198-like isoform X1. (351 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
DAPK2Death-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (365 aa)
IGDCC4Immunoglobulin superfamily DCC subclass member 4 isoform X1. (1247 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (661 aa)
LOC111185436Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
LOC111185435Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
LY96Lymphocyte antigen 96. (160 aa)
LOC111184077Tumor necrosis factor receptor superfamily member 26-like. (308 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
UNC5BNetrin receptor UNC5B isoform X1. (945 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1440 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa)
TMEM198Transmembrane protein 198. (360 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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