18 items (Delphinapterus leucas) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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gene neighborhood

gene fusions

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Your Input:
	FGFR3	Fibroblast growth factor receptor. (805 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111165935	Ras-like protein isoform X1. (285 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (798 aa)
	GAB1	GRB2-associated-binding protein 1 isoform X1. (757 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	GTPase KRas. (188 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	ERAS	GTPase ERas. (233 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	GRB2	A0A2Y9P0H2	A0A2Y9PJ90	Cold shock domain-containing protein E1 isoform X1.	Growth factor receptor-bound protein 2.	0.565
CSDE1	LOC111187198	A0A2Y9P0H2	A0A2Y9QG58	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
CSDE1	PIK3CA	A0A2Y9P0H2	A0A2Y9MZW2	Cold shock domain-containing protein E1 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.623
CSDE1	PTPN11	A0A2Y9P0H2	A0A2Y9QEG1	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
CSDE1	SOS1	A0A2Y9P0H2	A0A2Y9N647	Cold shock domain-containing protein E1 isoform X1.	Son of sevenless homolog 1 isoform X1.	0.607
ERAS	GRB2	A0A2Y9MKI3	A0A2Y9PJ90	GTPase ERas.	Growth factor receptor-bound protein 2.	0.565
ERAS	LOC111187198	A0A2Y9MKI3	A0A2Y9QG58	GTPase ERas.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.416
ERAS	PIK3CA	A0A2Y9MKI3	A0A2Y9MZW2	GTPase ERas.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.657
ERAS	PIK3R1	A0A2Y9MKI3	A0A2Y9Q8T5	GTPase ERas.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.441
ERAS	PTPN11	A0A2Y9MKI3	A0A2Y9QEG1	GTPase ERas.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.416
ERAS	SOS1	A0A2Y9MKI3	A0A2Y9N647	GTPase ERas.	Son of sevenless homolog 1 isoform X1.	0.642
FGF1	FGFR3	A0A2Y9PQS4	A0A2Y9LTY2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor.	0.983
FGF1	FRS2	A0A2Y9PQS4	A0A2Y9MXU5	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2.	0.523
FGF1	GAB1	A0A2Y9PQS4	A0A2Y9QCZ2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	GRB2-associated-binding protein 1 isoform X1.	0.543
FGF1	GRB2	A0A2Y9PQS4	A0A2Y9PJ90	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Growth factor receptor-bound protein 2.	0.503
FGF1	KRAS	A0A2Y9PQS4	A0A2Y9NF08	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	GTPase KRas.	0.418
FGF1	LOC111187198	A0A2Y9PQS4	A0A2Y9QG58	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.415
FGF1	PIK3CA	A0A2Y9PQS4	A0A2Y9MZW2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.414
FGF1	PTPN11	A0A2Y9PQS4	A0A2Y9QEG1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.421
FGF9	FGFR3	A0A2Y9N649	A0A2Y9LTY2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.955