29 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRAS	GTPase NRas. (189 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	GAB1	GRB2-associated-binding protein 1 isoform X1. (757 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	LOC111165935	Ras-like protein isoform X1. (285 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	KLB	LOW QUALITY PROTEIN: beta-klotho. (1046 aa)
	ERAS	GTPase ERas. (233 aa)
	FGFR4	Fibroblast growth factor receptor. (801 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	GTPase KRas. (188 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (798 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (495 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	FGF18	A0A2Y9P0H2	A0A2Y9Q5Q9	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
CSDE1	GRB2	A0A2Y9P0H2	A0A2Y9PJ90	Cold shock domain-containing protein E1 isoform X1.	Growth factor receptor-bound protein 2.	0.565
CSDE1	LOC111187198	A0A2Y9P0H2	A0A2Y9QG58	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
CSDE1	PIK3CA	A0A2Y9P0H2	A0A2Y9MZW2	Cold shock domain-containing protein E1 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.623
CSDE1	PTPN11	A0A2Y9P0H2	A0A2Y9QEG1	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
CSDE1	SOS1	A0A2Y9P0H2	A0A2Y9N647	Cold shock domain-containing protein E1 isoform X1.	Son of sevenless homolog 1 isoform X1.	0.607
ERAS	FGF18	A0A2Y9MKI3	A0A2Y9Q5Q9	GTPase ERas.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ERAS	FGF4	A0A2Y9MKI3	A0A2Y9PM63	GTPase ERas.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
ERAS	GRB2	A0A2Y9MKI3	A0A2Y9PJ90	GTPase ERas.	Growth factor receptor-bound protein 2.	0.565
ERAS	LOC111187198	A0A2Y9MKI3	A0A2Y9QG58	GTPase ERas.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.416
ERAS	PIK3CA	A0A2Y9MKI3	A0A2Y9MZW2	GTPase ERas.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.657
ERAS	PIK3R1	A0A2Y9MKI3	A0A2Y9Q8T5	GTPase ERas.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.441
ERAS	PTPN11	A0A2Y9MKI3	A0A2Y9QEG1	GTPase ERas.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.416
ERAS	SOS1	A0A2Y9MKI3	A0A2Y9N647	GTPase ERas.	Son of sevenless homolog 1 isoform X1.	0.642
FGF1	FGF16	A0A2Y9PQS4	A0A2Y9NR22	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
FGF1	FGF17	A0A2Y9PQS4	A0A2Y9MA36	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.690
FGF1	FGF18	A0A2Y9PQS4	A0A2Y9Q5Q9	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.504
FGF1	FGF23	A0A2Y9PQS4	A0A2Y9NG98	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.764
FGF1	FGF4	A0A2Y9PQS4	A0A2Y9PM63	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.614
FGF1	FGF6	A0A2Y9PQS4	A0A2Y9NDN3	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.558