STRINGSTRING
FGF1 FGF1 MKNK1 MKNK1 FNDC3A FNDC3A LOC111187198 LOC111187198 FGF9 FGF9 FNDC3B FNDC3B FRS2 FRS2 PPP2CB PPP2CB CBL CBL FGFR3 FGFR3 MKNK2 MKNK2 MAPK1 MAPK1 PTPN11 PTPN11 RPS27A RPS27A SRC SRC GRB2 GRB2 PPP2CA PPP2CA MAPK3 MAPK3 BRAF BRAF SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (463 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
SRCTyrosine-protein kinase. (562 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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