29 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
	SRC	Tyrosine-protein kinase. (562 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	BRAF	Serine/threonine-protein kinase B-raf isoform X1. (762 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
	MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	FGFR4	Fibroblast growth factor receptor. (801 aa)
	KLB	LOW QUALITY PROTEIN: beta-klotho. (1046 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	CBL	E3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
	MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (463 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	GRB2	A0A2Y9NQW5	A0A2Y9PJ90	Serine/threonine-protein kinase B-raf isoform X1.	Growth factor receptor-bound protein 2.	0.446
BRAF	MAPK1	A0A2Y9NQW5	A0A2Y9LEH4	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase.	0.827
BRAF	MAPK3	A0A2Y9NQW5	A0A2Y9PDR5	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.826
BRAF	PPP2CA	A0A2Y9NQW5	A0A2Y9PGY2	Serine/threonine-protein kinase B-raf isoform X1.	Serine/threonine-protein phosphatase.	0.477
BRAF	PPP2CB	A0A2Y9NQW5	A0A2Y9MWR6	Serine/threonine-protein kinase B-raf isoform X1.	Serine/threonine-protein phosphatase.	0.477
BRAF	PTPN11	A0A2Y9NQW5	A0A2Y9QEG1	Serine/threonine-protein kinase B-raf isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.509
BRAF	SPRY2	A0A2Y9NQW5	A0A2Y9NMR6	Serine/threonine-protein kinase B-raf isoform X1.	Protein sprouty homolog 2.	0.937
BRAF	SRC	A0A2Y9NQW5	A0A2Y9PSD7	Serine/threonine-protein kinase B-raf isoform X1.	Tyrosine-protein kinase.	0.540
CBL	FGF1	A0A2Y9M339	A0A2Y9PQS4	E3 ubiquitin-protein ligase CBL isoform X1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.449
CBL	FGF16	A0A2Y9M339	A0A2Y9NR22	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.544
CBL	FGF17	A0A2Y9M339	A0A2Y9MA36	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
CBL	FGF18	A0A2Y9M339	A0A2Y9Q5Q9	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
CBL	FGF20	A0A2Y9M339	A0A2Y9ND01	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.544
CBL	FGF23	A0A2Y9M339	A0A2Y9NG98	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.514
CBL	FGF4	A0A2Y9M339	A0A2Y9PM63	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
CBL	FGF6	A0A2Y9M339	A0A2Y9NDN3	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
CBL	FGF8	A0A2Y9M339	A0A2Y9N7L2	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
CBL	FGF9	A0A2Y9M339	A0A2Y9N649	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
CBL	FGFR4	A0A2Y9M339	A0A2Y9MM49	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor receptor.	0.843
CBL	FRS2	A0A2Y9M339	A0A2Y9MXU5	E3 ubiquitin-protein ligase CBL isoform X1.	Fibroblast growth factor receptor substrate 2.	0.811