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PTK2 PTK2 SH3GL1 SH3GL1 CBL CBL LAMA2 LAMA2 HRAS HRAS ERAS ERAS TNS1 TNS1 MUC20 MUC20 COL3A1 COL3A1 SH3KBP1 SH3KBP1 STAM2 STAM2 COL5A2 COL5A2 ARF6 ARF6 FNDC3B FNDC3B PIK3CA PIK3CA FN1 FN1 LRIG1 LRIG1 SH3GL2 SH3GL2 SOS1 SOS1 FNDC3A FNDC3A RAP1B RAP1B EPS15 EPS15 KRAS KRAS LAMB2 LAMB2 RAPGEF1 RAPGEF1 LAMC3 LAMC3 STAM STAM DOCK7 DOCK7 MET MET ITGB1 ITGB1 RANBP10 RANBP10 CSDE1 CSDE1 GGA3 GGA3 RAC1 RAC1 GRB2 GRB2 SPINT1 SPINT1 HGS HGS USP8 USP8 SPINT2 SPINT2 HPN HPN RAB4B RAB4B NRAS NRAS RANBP9 RANBP9 PTPN1 PTPN1 RAP1A RAP1A GAB1 GAB1 PIK3R1 PIK3R1 RPS27A RPS27A LAMC1 LAMC1 TNS3 TNS3 CRK CRK LAMB3 LAMB3 PTPN11 PTPN11 LOC111187198 LOC111187198 LAMB1 LAMB1 SRC SRC LAMC2 LAMC2 CRKL CRKL LAMA1 LAMA1 RAB4A RAB4A PTPN2 PTPN2 HGF HGF HGFAC HGFAC LOC111165935 LOC111165935 SH3GL3 SH3GL3 STAT3 STAT3 SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Focal adhesion kinase 1 isoform X22; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1116 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
LAMA2Laminin subunit alpha-2. (3008 aa)
HRASGTPase HRas isoform X1. (189 aa)
ERASGTPase ERas. (233 aa)
TNS1Tensin-1 isoform X1. (1914 aa)
MUC20Mucin-20 isoform X1. (530 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
COL5A2Collagen alpha-2(V) chain isoform X1. (1499 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FN1Fibronectin isoform X5. (2478 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1106 aa)
SH3GL2endophilin-A1. (352 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
KRASGTPase KRas. (188 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2131 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
RANBP10Ran-binding protein 10. (620 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GGA3ADP-ribosylation factor-binding protein GGA3 isoform X1. (758 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X2. (510 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1087 aa)
SPINT2Kunitz-type protease inhibitor 2. (249 aa)
HPNSerine protease hepsin isoform X1; Belongs to the peptidase S1 family. (599 aa)
RAB4BRas-related protein Rab-4B. (213 aa)
NRASGTPase NRas. (189 aa)
RANBP9Ran-binding protein 9. (499 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
TNS3Tensin-3 isoform X1. (1550 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
SRCTyrosine-protein kinase. (562 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
CRKLCrk-like protein. (303 aa)
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
RAB4ARas-related protein Rab-4A. (218 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
HGFACHepatocyte growth factor activator isoform X1. (702 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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