STRINGSTRING
PPP4R1 PPP4R1 MAPK1 MAPK1 KITLG KITLG MYD88 MYD88 HGF HGF FYN FYN FGF10 FGF10 INSR INSR VAV1 VAV1 FGFR3 FGFR3 STRN3 STRN3 INSC INSC PIP4K2B PIP4K2B PIK3R2 PIK3R2 ESR1 ESR1 ERBB2 ERBB2 TGFA TGFA PIP5K1C PIP5K1C PPP2R1B PPP2R1B FGF17 FGF17 PDGFA PDGFA KIT KIT PDGFRA PDGFRA LOC111167795 LOC111167795 PIP5K1A PIP5K1A CD80 CD80 IRAK1 IRAK1 IER3 IER3 CD86 CD86 SPEM1 SPEM1 LOC111171396 LOC111171396 LOC111170545 LOC111170545 KLB KLB LOC111171282 LOC111171282 FGFR4 FGFR4 ICOS ICOS IRS1 IRS1 SPEM2 SPEM2 CD28 CD28 FGFR2 FGFR2 ERBB4 ERBB4 ESR2 ESR2 FGF22 FGF22 PPP2CB PPP2CB FRS2 FRS2 FNDC3B FNDC3B PIK3CA PIK3CA ERBB3 ERBB3 IL33 IL33 PIP5K1B PIP5K1B PPP2R5E PPP2R5E IRAK4 IRAK4 STRN STRN NRG1 NRG1 FGF9 FGF9 FGFR1 FGFR1 PIK3AP1 PIK3AP1 FGF8 FGF8 FLT3 FLT3 IL1RAP IL1RAP PPP2R5C PPP2R5C PIK3R3 PIK3R3 IRS2 IRS2 FNDC3A FNDC3A FGF20 FGF20 FGF6 FGF6 PIP4K2C PIP4K2C PIP5KL1 PIP5KL1 KL KL FGF23 FGF23 FAM102A FAM102A LCK LCK FGF16 FGF16 PPP4R4 PPP4R4 NRG4 NRG4 PIP4K2A PIP4K2A WDR64 WDR64 MET MET PPP2R5D PPP2R5D CD276 CD276 KIAA1468 KIAA1468 BANK1 BANK1 PIK3CB PIK3CB FAM102B FAM102B FLT3LG FLT3LG PPP2R1A PPP2R1A TRAF6 TRAF6 CD19 CD19 STRN4 STRN4 NRG2 NRG2 MAPK3 MAPK3 HBEGF HBEGF PPP2CA PPP2CA GRB2 GRB2 FGF7 FGF7 PPP2R5B PPP2R5B LOC111181964 LOC111181964 PDGFRB PDGFRB RAC1 RAC1 FNBP4 FNBP4 FGF4 FGF4 PPP2R5A PPP2R5A FGF1 FGF1 SRC SRC NRG3 NRG3 FGF3 FGF3 INS INS RAC2 RAC2 PDGFB PDGFB EGFR EGFR LOC111186752 LOC111186752 GAB2 GAB2 ANKRD60 ANKRD60 FGF18 FGF18 AREG AREG PIK3R1 PIK3R1 EREG EREG EPGN EPGN GAB1 GAB1 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD IL1RL1 IL1RL1 BTC BTC FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (939 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
KITLGKit ligand isoform X1. (295 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FYNTyrosine-protein kinase. (537 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
STRN3Striatin-3 isoform X5. (796 aa)
INSCProtein inscuteable homolog. (649 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (293 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
SPEM1LOW QUALITY PROTEIN: spermatid maturation protein 1. (269 aa)
LOC111171396CD276 antigen-like. (120 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
LOC111171282Uncharacterized protein C17orf74-like. (436 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
ICOSInducible T-cell costimulator isoform X1. (227 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
SPEM2LOW QUALITY PROTEIN: uncharacterized protein C17orf74 homolog. (492 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ESR2Estrogen receptor beta. (558 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
IL33Interleukin-33 isoform X1. (271 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
STRNStriatin isoform X1. (809 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1 isoform X1. (806 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X2. (685 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (578 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (413 aa)
KLKlotho. (1010 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
FAM102AProtein FAM102A. (384 aa)
LCKTyrosine-protein kinase. (509 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (872 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (461 aa)
WDR64WD repeat-containing protein 64. (1081 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CD276CD276 antigen. (275 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
FAM102BProtein FAM102B isoform X1. (377 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
STRN4Striatin-4. (760 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
FNBP4Formin-binding protein 4. (1013 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
SRCTyrosine-protein kinase. (562 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC111186752T-cell receptor-associated transmembrane adapter 1. (185 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
ANKRD60LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60. (677 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
AREGAmphiregulin isoform X1. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
EREGProepiregulin. (163 aa)
EPGNEpigen. (153 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
IL1RL1Interleukin-1 receptor-like 1 isoform X1. (592 aa)
BTCProbetacellulin. (178 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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