STRINGSTRING
PPP2CA PPP2CA PSMC5 PSMC5 CDK3 CDK3 DBF4 DBF4 PPP2R1A PPP2R1A CABLES1 CABLES1 PSMD8 PSMD8 PPP2R3A PPP2R3A PSMB10 PSMB10 MCM3 MCM3 CCNE1 CCNE1 RPA3 RPA3 CCNE2 CCNE2 PSMB8 PSMB8 PRIM2 PRIM2 PSMC4 PSMC4 PSMA4 PSMA4 KIAA1468 KIAA1468 PSMA5 PSMA5 CDT1 CDT1 PSMD7 PSMD7 CDKN1B CDKN1B CDKN1A CDKN1A PSMB7 PSMB7 PPP4R4 PPP4R4 PSMB9 PSMB9 POLE3 POLE3 PSMD5 PSMD5 CUL1 CUL1 WEE2 WEE2 ORC1 ORC1 PSMB2 PSMB2 CCNA1 CCNA1 PSMC1 PSMC1 MNAT1 MNAT1 MCM6 MCM6 PRIM1 PRIM1 CDC25A CDC25A CDC45 CDC45 PPP4R1 PPP4R1 RPA2 RPA2 ORC3 ORC3 PSME2 PSME2 PSME1 PSME1 PSMB5 PSMB5 PSMC2 PSMC2 PSMA1 PSMA1 ORC6 ORC6 WEE1 WEE1 MCM8 MCM8 PSMD10 PSMD10 CDC7 CDC7 CDC6 CDC6 MCM9 MCM9 LOC111166275 LOC111166275 KXD1 KXD1 ORC5 ORC5 PSMD3 PSMD3 PSMB3 PSMB3 MCM4 MCM4 CKS1B CKS1B POLA1 POLA1 PSMB1 PSMB1 CKS2 CKS2 PPP2R1B PPP2R1B LOC111166421 LOC111166421 PPP2R3B PPP2R3B PSMD13 PSMD13 PSMB4 PSMB4 PSMD6 PSMD6 CDK2 CDK2 TM4SF19 TM4SF19 CDK4 CDK4 PPP2CB PPP2CB PSMA3 PSMA3 PPP2R3C PPP2R3C PSMA6 PSMA6 POLE2 POLE2 PSMC6 PSMC6 PSMD14 PSMD14 ORC4 ORC4 PSMD1 PSMD1 PSMD4 PSMD4 POLE4 POLE4 MCM2 MCM2 ORC2 ORC2 KIAA2012 KIAA2012 LOC111171144 LOC111171144 LOC111169208 LOC111169208 GMNN GMNN POLE POLE PSMD9 PSMD9 PSMA7 PSMA7 PTK6 PTK6 SKP2 SKP2 MCM5 MCM5 PSMB6 PSMB6 PSMD11 PSMD11 RPA1 RPA1 ANKRD60 ANKRD60 RPS27A RPS27A CCNH CCNH PSMA2 PSMA2 CCNA2 CCNA2 PSMF1 PSMF1 CDK7 CDK7 MEIOB MEIOB PSMD12 PSMD12 PSMC3 PSMC3 POLA2 POLA2 SKP1 SKP1 CCND1 CCND1 FNBP4 FNBP4 MCM7 MCM7 CDKN1C CDKN1C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
CDK3Cyclin-dependent kinase 3 isoform X3; Belongs to the protein kinase superfamily. (360 aa)
DBF4Protein DBF4 homolog A isoform X1. (679 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
CABLES1CDK5 and ABL1 enzyme substrate 1 isoform X1. (646 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
PSMB10Proteasome subunit beta. (273 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
RPA3Replication protein A 14 kDa subunit isoform X1. (121 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
PSMB8Proteasome subunit beta. (276 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (524 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDT1DNA replication factor Cdt1. (551 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PSMB7Proteasome subunit beta. (277 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (872 aa)
PSMB9Proteasome subunit beta. (219 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
WEE2Wee1-like protein kinase 2. (419 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
PSMB2Proteasome subunit beta. (201 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
PSMC126S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PRIM1DNA primase small subunit. (94 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (939 aa)
RPA2LOW QUALITY PROTEIN: replication protein A 32 kDa subunit. (362 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (713 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
ORC6Origin recognition complex subunit 6. (273 aa)
WEE1Wee1-like protein kinase. (646 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (832 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
CDC7Cell division cycle 7-related protein kinase. (573 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (647 aa)
MCM9DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1144 aa)
LOC111166275Proteasome activator complex subunit 3-like. (165 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMB3Proteasome subunit beta. (205 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
POLA1DNA polymerase. (1468 aa)
PSMB1Proteasome subunit beta. (241 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
LOC111166421Proteasome activator complex subunit 3. (254 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (578 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (452 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
TM4SF19Transmembrane 4 L6 family member 19. (202 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (954 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)
POLE4DNA polymerase epsilon subunit 4 isoform X1. (116 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
KIAA2012Uncharacterized protein KIAA2012 homolog. (1171 aa)
LOC111171144DNA primase; Belongs to the eukaryotic-type primase small subunit family. (310 aa)
LOC111169208Wee1-like protein kinase. (443 aa)
GMNNGeminin. (210 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PTK6Non-specific protein-tyrosine kinase. (354 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
ANKRD60LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60. (677 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CCNHcyclin-H; Belongs to the cyclin family. (323 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (270 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
PSMC326S proteasome regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (423 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (164 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
FNBP4Formin-binding protein 4. (1013 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (257 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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