12 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB10	Growth factor receptor-bound protein 10 isoform X1. (588 aa)
	LOC111187339	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC111181964	Uncharacterized protein LOC111181964 isoform X1. (833 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	INSR	Tyrosine-protein kinase receptor. (1392 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB10	GRB2	A0A2Y9PPV4	A0A2Y9PJ90	Growth factor receptor-bound protein 10 isoform X1.	Growth factor receptor-bound protein 2.	0.582
GRB10	INS	A0A2Y9PPV4	A0A2Y9PTW5	Growth factor receptor-bound protein 10 isoform X1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.656
GRB10	INSR	A0A2Y9PPV4	A0A2Y9LSN6	Growth factor receptor-bound protein 10 isoform X1.	Tyrosine-protein kinase receptor.	0.973
GRB10	IRS1	A0A2Y9PPV4	A0A2Y9MMM9	Growth factor receptor-bound protein 10 isoform X1.	Insulin receptor substrate 1.	0.566
GRB10	IRS2	A0A2Y9PPV4	A0A2Y9NC55	Growth factor receptor-bound protein 10 isoform X1.	Insulin receptor substrate 2.	0.401
GRB10	LOC111181964	A0A2Y9PPV4	A0A2Y9PK20	Growth factor receptor-bound protein 10 isoform X1.	Uncharacterized protein LOC111181964 isoform X1.	0.401
GRB10	LOC111187339	A0A2Y9PPV4	A0A2Y9QAJ0	Growth factor receptor-bound protein 10 isoform X1.	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like.	0.901
GRB2	GRB10	A0A2Y9PJ90	A0A2Y9PPV4	Growth factor receptor-bound protein 2.	Growth factor receptor-bound protein 10 isoform X1.	0.582
GRB2	INS	A0A2Y9PJ90	A0A2Y9PTW5	Growth factor receptor-bound protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.706
GRB2	INSR	A0A2Y9PJ90	A0A2Y9LSN6	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.967
GRB2	IRS1	A0A2Y9PJ90	A0A2Y9MMM9	Growth factor receptor-bound protein 2.	Insulin receptor substrate 1.	0.995
GRB2	IRS2	A0A2Y9PJ90	A0A2Y9NC55	Growth factor receptor-bound protein 2.	Insulin receptor substrate 2.	0.982
GRB2	LOC111181964	A0A2Y9PJ90	A0A2Y9PK20	Growth factor receptor-bound protein 2.	Uncharacterized protein LOC111181964 isoform X1.	0.980
GRB2	LOC111187339	A0A2Y9PJ90	A0A2Y9QAJ0	Growth factor receptor-bound protein 2.	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like.	0.582
GRB2	MAPK1	A0A2Y9PJ90	A0A2Y9LEH4	Growth factor receptor-bound protein 2.	Mitogen-activated protein kinase.	0.604
GRB2	MAPK3	A0A2Y9PJ90	A0A2Y9PDR5	Growth factor receptor-bound protein 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.458
GRB2	SHC1	A0A2Y9PJ90	A0A2Y9LZK9	Growth factor receptor-bound protein 2.	SHC-transforming protein 1 isoform X1.	0.999
GRB2	SOS1	A0A2Y9PJ90	A0A2Y9N647	Growth factor receptor-bound protein 2.	Son of sevenless homolog 1 isoform X1.	0.999
INS	GRB10	A0A2Y9PTW5	A0A2Y9PPV4	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10 isoform X1.	0.656
INS	GRB2	A0A2Y9PTW5	A0A2Y9PJ90	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 2.	0.706