STRINGSTRING
PDPK1 PDPK1 FGF18 FGF18 ATP6V0A2 ATP6V0A2 PIK3R1 PIK3R1 LOC111187339 LOC111187339 FGFR3 FGFR3 ATP6V1A ATP6V1A ATP6V1C2 ATP6V1C2 ATP6V0A1 ATP6V0A1 PIK3R2 PIK3R2 PIK3R4 PIK3R4 PDE3B PDE3B ATP6V1H ATP6V1H SHC1 SHC1 GAB1 GAB1 PTPN1 PTPN1 PTPN11 PTPN11 PIK3C3 PIK3C3 THEM4 THEM4 CTSD CTSD ATP6V1B2 ATP6V1B2 SPEM1 SPEM1 KLB KLB ATP6V1G3 ATP6V1G3 LOC111171282 LOC111171282 FGFR4 FGFR4 IRS1 IRS1 SPEM2 SPEM2 FGFR2 FGFR2 ATP6V1D ATP6V1D FGF22 FGF22 ATP6V1G2 ATP6V1G2 FRS2 FRS2 ATP6AP1 ATP6AP1 PIK3CA PIK3CA SOS1 SOS1 FGF9 FGF9 FGFR1 FGFR1 TLR9 TLR9 IDE IDE FGF8 FGF8 FLT3 FLT3 PTPRF PTPRF AKT1 AKT1 IRS2 IRS2 FGF20 FGF20 FGF6 FGF6 KL KL FGF23 FGF23 ATP6V0B ATP6V0B ATP6V1E1 ATP6V1E1 NRDC NRDC ATP6V1F ATP6V1F FGF16 FGF16 ATP6V1G1 ATP6V1G1 ATP6V0E2 ATP6V0E2 CNST CNST PIK3CB PIK3CB ATP6V1C1 ATP6V1C1 FLT3LG FLT3LG ATP6V0D1 ATP6V0D1 AKT2 AKT2 MAPK3 MAPK3 LIM2 LIM2 ATP6V0A4 ATP6V0A4 GRB2 GRB2 FGF7 FGF7 LOC111181964 LOC111181964 FGF4 FGF4 FGF5 FGF5 GRB10 GRB10 FGF1 FGF1 TRIB3 TRIB3 FGF3 FGF3 INS INS TCIRG1 TCIRG1 ATP6V0E1 ATP6V0E1 ATP6AP1L ATP6AP1L GAB2 GAB2 LOC111169445 LOC111169445 FGF17 FGF17 ATP6V1B1 ATP6V1B1 LOC111187198 LOC111187198 MAPK1 MAPK1 ATP6V0D2 ATP6V0D2 FGF10 FGF10 INSR INSR ATP6V0C ATP6V0C
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (867 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC111187339LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
ATP6V1ALOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A. (621 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
PDE3BPhosphodiesterase. (1120 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (224 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (411 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
SPEM1LOW QUALITY PROTEIN: spermatid maturation protein 1. (269 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (198 aa)
LOC111171282Uncharacterized protein C17orf74-like. (436 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
SPEM2LOW QUALITY PROTEIN: uncharacterized protein C17orf74 homolog. (492 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ATP6V1DV-type proton ATPase subunit D isoform X1. (247 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ATP6AP1V-type proton ATPase subunit S1. (469 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
IDEInsulin-degrading enzyme isoform X2; Belongs to the peptidase M16 family. (1052 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1917 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KLKlotho. (1010 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (233 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
NRDCNardilysin isoform X1. (1228 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0E2V-type proton ATPase subunit e 2. (112 aa)
CNSTConsortin isoform X1. (722 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6AP1LLOW QUALITY PROTEIN: V-type proton ATPase subunit S1-like protein. (305 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
LOC111169445Acyl-coenzyme A thioesterase THEM4-like. (174 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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