STRINGSTRING
ARRB2 ARRB2 COPS7B COPS7B UBQLN3 UBQLN3 SYT8 SYT8 AP2A2 AP2A2 SH3KBP1 SH3KBP1 AGFG1 AGFG1 STAM2 STAM2 GPR52 GPR52 LRP2 LRP2 AP2M1 AP2M1 CLPB CLPB TFRC TFRC LOC111170925 LOC111170925 ADRB1 ADRB1 LOC111174157 LOC111174157 STON1 STON1 SH3GL2 SH3GL2 WNT5A WNT5A APOB APOB STON2 STON2 EPS15 EPS15 COPS7A COPS7A NECAP1 NECAP1 KIAA0319L KIAA0319L TOR1B TOR1B M6PR M6PR SLC2A8 SLC2A8 GPR21 GPR21 ITSN2 ITSN2 LOC111177605 LOC111177605 STAM STAM UBL7 UBL7 TOR1A TOR1A TF TF CFTR CFTR SGIP1 SGIP1 LOC111179199 LOC111179199 EPN1 EPN1 COPS2 COPS2 AGFG2 AGFG2 AGTR1 AGTR1 LDLRAP1 LDLRAP1 ITSN1 ITSN1 GRK3 GRK3 AP2S1 AP2S1 GPS1 GPS1 AP2A1 AP2A1 HBEGF HBEGF SNAP91 SNAP91 HGS HGS ZFYVE19 ZFYVE19 GRK2 GRK2 GRB2 GRB2 COPS6 COPS6 AVP AVP ADRB2 ADRB2 PICALM PICALM FZD4 FZD4 VAMP2 VAMP2 FCHO2 FCHO2 COPS5 COPS5 EGFR EGFR RPS27A RPS27A ARRB1 ARRB1 COPS8 COPS8 NECAP2 NECAP2 PPP1R42 PPP1R42 MCTP2 MCTP2 DVL2 DVL2 LMBRD2 LMBRD2 IL7R IL7R AREG AREG DAB2 DAB2 CLTA CLTA ENTHD1 ENTHD1 CLHC1 CLHC1 EREG EREG EPGN EPGN VAMP3 VAMP3 SCARB2 SCARB2 COPS4 COPS4 BMP2K BMP2K BTC BTC CD4 CD4 CLTC CLTC NEDD8 NEDD8 NETO2 NETO2 LOC111163515 LOC111163515 SH3GL3 SH3GL3 REPS1 REPS1 KXD1 KXD1 FCHO1 FCHO1 VAMP5 VAMP5 TGOLN2 TGOLN2 VAMP8 VAMP8 CD3D CD3D CD3G CD3G SYT11 SYT11 UBQLN4 UBQLN4 UBQLN1 UBQLN1 NETO1 NETO1 VAMP4 VAMP4 SH3GL1 SH3GL1 CBL CBL COPS3 COPS3 SYT1 SYT1 EPN2 EPN2 TGFA TGFA ARR3 ARR3 AAK1 AAK1 LDLR LDLR KIAA0319 KIAA0319 SYT4 SYT4 EPS15L1 EPS15L1 UBQLN2 UBQLN2 SYT9 SYT9 SYT2 SYT2 IGF2R IGF2R SLC18A3 SLC18A3 REPS2 REPS2 TACR1 TACR1 VAMP7 VAMP7 CLTB CLTB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
COPS7BCOP9 signalosome complex subunit 7b. (264 aa)
UBQLN3Ubiquilin-3. (659 aa)
SYT8LOW QUALITY PROTEIN: synaptotagmin-8. (385 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
AGFG1arf-GAP domain and FG repeat-containing protein 1 isoform X1. (605 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
GPR52Probable G-protein coupled receptor 52; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4838 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (677 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
LOC111170925Zinc finger FYVE domain-containing protein 1-like isoform X1. (325 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
LOC111174157LOW QUALITY PROTEIN: neuropilin and tolloid-like protein 2. (298 aa)
STON1Stonin-1; Belongs to the Stoned B family. (730 aa)
SH3GL2endophilin-A1. (352 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
APOBApolipoprotein B-100. (4566 aa)
STON2Stonin-2 isoform X1; Belongs to the Stoned B family. (897 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
COPS7ACOP9 signalosome complex subunit 7a isoform X1. (283 aa)
NECAP1Adaptin ear-binding coat-associated protein 1. (275 aa)
KIAA0319LDyslexia-associated protein KIAA0319-like protein homolog isoform X1. (1044 aa)
TOR1BTorsin. (335 aa)
M6PRCation-dependent mannose-6-phosphate receptor isoform X1. (316 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
ITSN2Intersectin-2 isoform X1. (1667 aa)
LOC111177605Ubiquitin-like protein 7. (130 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
UBL7Ubiquitin-like protein 7 isoform X1. (488 aa)
TOR1Atorsin-1A. (416 aa)
TFSerotransferrin; Belongs to the transferrin family. (702 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (854 aa)
LOC111179199Serotransferrin-like; Belongs to the transferrin family. (706 aa)
EPN1LOW QUALITY PROTEIN: epsin-1. (576 aa)
COPS2COP9 signalosome complex subunit 2 isoform X1. (450 aa)
AGFG2arf-GAP domain and FG repeat-containing protein 2 isoform X1. (494 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
GPS1COP9 signalosome complex subunit 1 isoform X4. (599 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
SNAP91Clathrin coat assembly protein AP180 isoform X1. (907 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
ZFYVE19abscission/NoCut checkpoint regulator isoform X1. (398 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
COPS6COP9 signalosome complex subunit 6 isoform X1. (333 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
FCHO2F-BAR domain only protein 2 isoform X2. (810 aa)
COPS5COP9 signalosome complex subunit 5 isoform X1. (334 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
COPS8COP9 signalosome complex subunit 8. (209 aa)
NECAP2Adaptin ear-binding coat-associated protein 2 isoform X3. (322 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42 isoform X1. (353 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2 isoform X2. (879 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
LMBRD2LMBR1 domain-containing protein 2 isoform X1. (695 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
AREGAmphiregulin isoform X1. (254 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
ENTHD1ENTH domain-containing protein 1. (610 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1 isoform X1. (624 aa)
EREGProepiregulin. (163 aa)
EPGNEpigen. (153 aa)
VAMP3Vesicle-associated membrane protein 3. (104 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (477 aa)
COPS4COP9 signalosome complex subunit 4 isoform X1. (406 aa)
BMP2KBMP-2-inducible protein kinase isoform X1. (1124 aa)
BTCProbetacellulin. (178 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
NEDD8NEDD8 isoform X1. (98 aa)
NETO2Neuropilin and tolloid-like protein 2 isoform X1. (525 aa)
LOC111163515Uncharacterized protein LOC111163515. (1806 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
REPS1ralBP1-associated Eps domain-containing protein 1 isoform X1. (802 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
FCHO1F-BAR domain only protein 1. (887 aa)
VAMP5Vesicle-associated membrane protein 5. (116 aa)
TGOLN2trans-Golgi network integral membrane protein 2 isoform X1. (320 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
UBQLN4Ubiquilin-4. (601 aa)
UBQLN1Ubiquilin-1 isoform X1. (590 aa)
NETO1Neuropilin and tolloid-like protein 1 isoform X1. (532 aa)
VAMP4Vesicle-associated membrane protein 4 isoform X1. (141 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
COPS3COP9 signalosome complex subunit 3 isoform X1. (423 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
EPN2Epsin-2 isoform X1. (582 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
ARR3arrestin-C. (339 aa)
AAK1AP2-associated protein kinase 1 isoform X1. (968 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog isoform X1. (1076 aa)
SYT4Synaptotagmin-4. (425 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X1. (947 aa)
UBQLN2LOW QUALITY PROTEIN: ubiquilin-2. (624 aa)
SYT9Synaptotagmin-9 isoform X1. (503 aa)
SYT2Synaptotagmin-2 isoform X1. (428 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2490 aa)
SLC18A3Vesicular acetylcholine transporter. (528 aa)
REPS2ralBP1-associated Eps domain-containing protein 2 isoform X1. (648 aa)
TACR1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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