STRINGSTRING
EREG EREG CLHC1 CLHC1 ENTHD1 ENTHD1 CLTA CLTA DAB2 DAB2 ARPC3 ARPC3 AREG AREG IL7R IL7R LMBRD2 LMBRD2 SNX18 SNX18 DVL2 DVL2 MCTP2 MCTP2 PPP1R42 PPP1R42 ACTR2 ACTR2 PACSIN2 PACSIN2 NECAP2 NECAP2 ARRB2 ARRB2 ARRB1 ARRB1 RPS27A RPS27A ARPC5 ARPC5 EGFR EGFR LOC111184478 LOC111184478 SYT9 SYT9 HSPA8 HSPA8 ARPC4 ARPC4 SYT2 SYT2 ACTB ACTB IGF2R IGF2R SLC18A3 SLC18A3 REPS2 REPS2 EPS15L1 EPS15L1 SYT4 SYT4 KIAA0319 KIAA0319 LDLR LDLR PIP5K1C PIP5K1C COPS7A COPS7A EPS15 EPS15 STON2 STON2 APOB APOB SH3D21 SH3D21 RAB5B RAB5B WNT5A WNT5A SH3GL2 SH3GL2 STON1 STON1 LOC111174157 LOC111174157 ADRB1 ADRB1 LOC111170925 LOC111170925 TFRC TFRC ARPC2 ARPC2 CLPB CLPB TOR1A TOR1A UBL7 UBL7 STAM STAM PACSIN1 PACSIN1 DNM1 DNM1 LOC111177605 LOC111177605 ITSN2 ITSN2 GPR21 GPR21 GAPVD1 GAPVD1 SLC2A8 SLC2A8 M6PR M6PR TOR1B TOR1B ACTR3B ACTR3B KIAA0319L KIAA0319L FNBP1 FNBP1 NECAP1 NECAP1 AAK1 AAK1 OCRL OCRL ARR3 ARR3 TGFA TGFA SYNJ2 SYNJ2 EPN2 EPN2 SYT1 SYT1 COPS3 COPS3 CBL CBL SNX9 SNX9 SH3GL1 SH3GL1 DNM3 DNM3 TRIP10 TRIP10 VAMP4 VAMP4 NETO1 NETO1 UBQLN1 UBQLN1 UBQLN4 UBQLN4 SYT11 SYT11 RAB5A RAB5A CD3G CD3G AP2M1 AP2M1 LRP2 LRP2 GPR52 GPR52 STAM2 STAM2 AGFG1 AGFG1 SH3KBP1 SH3KBP1 AP2A2 AP2A2 SYT8 SYT8 UBQLN3 UBQLN3 COPS7B COPS7B COPS8 COPS8 CLTB CLTB VAMP7 VAMP7 TACR1 TACR1 SNX33 SNX33 ARPC5L ARPC5L WASL WASL TF TF CFTR CFTR SGIP1 SGIP1 DNAJC6 DNAJC6 LOC111179199 LOC111179199 CD3D CD3D EPN1 EPN1 COPS2 COPS2 FMN1 FMN1 AGFG2 AGFG2 AP2S1 AP2S1 GPS1 GPS1 AP2A1 AP2A1 ARPC1A ARPC1A VAMP8 VAMP8 TGOLN2 TGOLN2 VAMP5 VAMP5 FCHO1 FCHO1 PIK3C2A PIK3C2A KXD1 KXD1 HBEGF HBEGF SNAP91 SNAP91 HGS HGS ACTG1 ACTG1 ZFYVE19 ZFYVE19 GRK2 GRK2 GRB2 GRB2 COPS6 COPS6 HIP1 HIP1 ACTR3 ACTR3 CTTN CTTN AVP AVP UBQLN2 UBQLN2 REPS1 REPS1 RAB5C RAB5C DNM2 DNM2 SH3GL3 SH3GL3 LOC111163515 LOC111163515 SYNJ1 SYNJ1 NETO2 NETO2 GAK GAK NEDD8 NEDD8 CLTC CLTC FNBP1L FNBP1L GRK3 GRK3 ITSN1 ITSN1 ACTL8 ACTL8 LDLRAP1 LDLRAP1 ACTBL2 ACTBL2 AGTR1 AGTR1 ADRB2 ADRB2 FMN2 FMN2 PICALM PICALM BIN1 BIN1 LOC111184479 LOC111184479 FZD4 FZD4 PACSIN3 PACSIN3 VAMP2 VAMP2 GAS7 GAS7 FCHO2 FCHO2 COPS5 COPS5 CD4 CD4 BTC BTC BMP2K BMP2K COPS4 COPS4 SCARB2 SCARB2 VAMP3 VAMP3 HIP1R HIP1R EPGN EPGN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EREGProepiregulin. (163 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1 isoform X1. (624 aa)
ENTHD1ENTH domain-containing protein 1. (610 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
AREGAmphiregulin isoform X1. (254 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
LMBRD2LMBR1 domain-containing protein 2 isoform X1. (695 aa)
SNX18Sorting nexin. (625 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2 isoform X2. (879 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42 isoform X1. (353 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons protein 2 isoform X1. (486 aa)
NECAP2Adaptin ear-binding coat-associated protein 2 isoform X3. (322 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC111184478Amphiphysin isoform X1. (685 aa)
SYT9Synaptotagmin-9 isoform X1. (503 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (650 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
SYT2Synaptotagmin-2 isoform X1. (428 aa)
ACTBActin, cytoplasmic 1. (375 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2490 aa)
SLC18A3Vesicular acetylcholine transporter. (528 aa)
REPS2ralBP1-associated Eps domain-containing protein 2 isoform X1. (648 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X1. (947 aa)
SYT4Synaptotagmin-4. (425 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog isoform X1. (1076 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
COPS7ACOP9 signalosome complex subunit 7a isoform X1. (283 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
STON2Stonin-2 isoform X1; Belongs to the Stoned B family. (897 aa)
APOBApolipoprotein B-100. (4566 aa)
SH3D21LOW QUALITY PROTEIN: SH3 domain-containing protein 21. (802 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
SH3GL2endophilin-A1. (352 aa)
STON1Stonin-1; Belongs to the Stoned B family. (730 aa)
LOC111174157LOW QUALITY PROTEIN: neuropilin and tolloid-like protein 2. (298 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
LOC111170925Zinc finger FYVE domain-containing protein 1-like isoform X1. (325 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (677 aa)
TOR1Atorsin-1A. (416 aa)
UBL7Ubiquitin-like protein 7 isoform X1. (488 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons protein 1. (444 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
LOC111177605Ubiquitin-like protein 7. (130 aa)
ITSN2Intersectin-2 isoform X1. (1667 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
GAPVD1GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1. (1460 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
M6PRCation-dependent mannose-6-phosphate receptor isoform X1. (316 aa)
TOR1BTorsin. (335 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
KIAA0319LDyslexia-associated protein KIAA0319-like protein homolog isoform X1. (1044 aa)
FNBP1Formin-binding protein 1 isoform X2. (649 aa)
NECAP1Adaptin ear-binding coat-associated protein 1. (275 aa)
AAK1AP2-associated protein kinase 1 isoform X1. (968 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform X1. (893 aa)
ARR3arrestin-C. (339 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SYNJ2Synaptojanin-2 isoform X1. (1478 aa)
EPN2Epsin-2 isoform X1. (582 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
COPS3COP9 signalosome complex subunit 3 isoform X1. (423 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
SNX9Sorting nexin. (594 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (873 aa)
TRIP10Cdc42-interacting protein 4 isoform X4. (602 aa)
VAMP4Vesicle-associated membrane protein 4 isoform X1. (141 aa)
NETO1Neuropilin and tolloid-like protein 1 isoform X1. (532 aa)
UBQLN1Ubiquilin-1 isoform X1. (590 aa)
UBQLN4Ubiquilin-4. (601 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4838 aa)
GPR52Probable G-protein coupled receptor 52; Belongs to the G-protein coupled receptor 1 family. (361 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
AGFG1arf-GAP domain and FG repeat-containing protein 1 isoform X1. (605 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
SYT8LOW QUALITY PROTEIN: synaptotagmin-8. (385 aa)
UBQLN3Ubiquilin-3. (659 aa)
COPS7BCOP9 signalosome complex subunit 7b. (264 aa)
COPS8COP9 signalosome complex subunit 8. (209 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
TACR1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SNX33Sorting nexin. (574 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
TFSerotransferrin; Belongs to the transferrin family. (702 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (854 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin isoform X1. (971 aa)
LOC111179199Serotransferrin-like; Belongs to the transferrin family. (706 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
EPN1LOW QUALITY PROTEIN: epsin-1. (576 aa)
COPS2COP9 signalosome complex subunit 2 isoform X1. (450 aa)
FMN1Formin-1 isoform X2. (1200 aa)
AGFG2arf-GAP domain and FG repeat-containing protein 2 isoform X1. (494 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
GPS1COP9 signalosome complex subunit 1 isoform X4. (599 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
TGOLN2trans-Golgi network integral membrane protein 2 isoform X1. (320 aa)
VAMP5Vesicle-associated membrane protein 5. (116 aa)
FCHO1F-BAR domain only protein 1. (887 aa)
PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1; Belongs to the PI3/PI4-kinase family. (1711 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
SNAP91Clathrin coat assembly protein AP180 isoform X1. (907 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ZFYVE19abscission/NoCut checkpoint regulator isoform X1. (398 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
COPS6COP9 signalosome complex subunit 6 isoform X1. (333 aa)
HIP1Huntingtin-interacting protein 1 isoform X1. (1037 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
CTTNSrc substrate cortactin isoform X3. (538 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
UBQLN2LOW QUALITY PROTEIN: ubiquilin-2. (624 aa)
REPS1ralBP1-associated Eps domain-containing protein 1 isoform X1. (802 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
LOC111163515Uncharacterized protein LOC111163515. (1806 aa)
SYNJ1Synaptojanin-1 isoform X2. (1592 aa)
NETO2Neuropilin and tolloid-like protein 2 isoform X1. (525 aa)
GAKcyclin-G-associated kinase isoform X1. (1273 aa)
NEDD8NEDD8 isoform X1. (98 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
FNBP1LFormin-binding protein 1-like isoform X3. (609 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
ITSN1Intersectin-1 isoform X1. (1715 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
ACTBL2LOW QUALITY PROTEIN: beta-actin-like protein 2; Belongs to the actin family. (373 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X1. (594 aa)
LOC111184479Uncharacterized protein LOC111184479. (594 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons protein 3. (424 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
GAS7Growth arrest-specific protein 7 isoform X1. (488 aa)
FCHO2F-BAR domain only protein 2 isoform X2. (810 aa)
COPS5COP9 signalosome complex subunit 5 isoform X1. (334 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
BTCProbetacellulin. (178 aa)
BMP2KBMP-2-inducible protein kinase isoform X1. (1124 aa)
COPS4COP9 signalosome complex subunit 4 isoform X1. (406 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (477 aa)
VAMP3Vesicle-associated membrane protein 3. (104 aa)
HIP1RHuntingtin-interacting protein 1-related protein isoform X1. (1068 aa)
EPGNEpigen. (153 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (14%) [HD]