9 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	CCND2	G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
	CCND3	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
	PML	Protein PML isoform X1. (861 aa)
	CDK6	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	TNRC6B	Trinucleotide repeat-containing gene 6B protein isoform X1. (1867 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	CCND2	A0A2Y9PNM2	A0A2Y9NG81	G1/S-specific cyclin-D1; Belongs to the cyclin family.	G1/S-specific cyclin-D2; Belongs to the cyclin family.	0.935
CCND1	CCND3	A0A2Y9PNM2	A0A2Y9NR31	G1/S-specific cyclin-D1; Belongs to the cyclin family.	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	0.938
CCND1	CDK6	A0A2Y9PNM2	A0A2Y9P3B0	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.999
CCND1	RUNX1	A0A2Y9PNM2	A0A2Y9LIS3	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.538
CCND2	CCND1	A0A2Y9NG81	A0A2Y9PNM2	G1/S-specific cyclin-D2; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.935
CCND2	CCND3	A0A2Y9NG81	A0A2Y9NR31	G1/S-specific cyclin-D2; Belongs to the cyclin family.	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	0.930
CCND2	CDK6	A0A2Y9NG81	A0A2Y9P3B0	G1/S-specific cyclin-D2; Belongs to the cyclin family.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.999
CCND2	RUNX1	A0A2Y9NG81	A0A2Y9LIS3	G1/S-specific cyclin-D2; Belongs to the cyclin family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.473
CCND3	CCND1	A0A2Y9NR31	A0A2Y9PNM2	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.938
CCND3	CCND2	A0A2Y9NR31	A0A2Y9NG81	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	G1/S-specific cyclin-D2; Belongs to the cyclin family.	0.930
CCND3	CDK6	A0A2Y9NR31	A0A2Y9P3B0	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.999
CCND3	RUNX1	A0A2Y9NR31	A0A2Y9LIS3	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.473
CDK6	CCND1	A0A2Y9P3B0	A0A2Y9PNM2	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.999
CDK6	CCND2	A0A2Y9P3B0	A0A2Y9NG81	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-D2; Belongs to the cyclin family.	0.999
CDK6	CCND3	A0A2Y9P3B0	A0A2Y9NR31	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	0.999
CDK6	RUNX1	A0A2Y9P3B0	A0A2Y9LIS3	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.741
LOC111187198	PTPN11	A0A2Y9QG58	A0A2Y9QEG1	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.902
LOC111187198	RUNX1	A0A2Y9QG58	A0A2Y9LIS3	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.441
PML	RUNX1	A0A2Y9NS17	A0A2Y9LIS3	Protein PML isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.929
PTPN11	LOC111187198	A0A2Y9QEG1	A0A2Y9QG58	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.902