17 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
	GAB1	GRB2-associated-binding protein 1 isoform X1. (757 aa)
	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	VAV1	Proto-oncogene vav isoform X1. (845 aa)
	LOC111165942	Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
	CRKL	Crk-like protein. (303 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	EPO	A0A2Y9LB74	A0A2Y9PM33	Crk-like protein.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.507
CRKL	GAB1	A0A2Y9LB74	A0A2Y9QCZ2	Crk-like protein.	GRB2-associated-binding protein 1 isoform X1.	0.986
CRKL	GRB2	A0A2Y9LB74	A0A2Y9PJ90	Crk-like protein.	Growth factor receptor-bound protein 2.	0.815
CRKL	IRS2	A0A2Y9LB74	A0A2Y9NC55	Crk-like protein.	Insulin receptor substrate 2.	0.443
CRKL	JAK2	A0A2Y9LB74	A0A2Y9N3T7	Crk-like protein.	Tyrosine-protein kinase.	0.610
CRKL	LOC111165942	A0A2Y9LB74	A0A2Y9LSV2	Crk-like protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.636
CRKL	LYN	A0A2Y9LB74	A0A2Y9LZZ2	Crk-like protein.	Tyrosine-protein kinase.	0.652
CRKL	PIK3CA	A0A2Y9LB74	A0A2Y9MZW2	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.762
CRKL	PIK3CB	A0A2Y9LB74	A0A2Y9NZC3	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.725
CRKL	PIK3CD	A0A2Y9LB74	A0A2Y9QGK3	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.728
CRKL	PIK3R1	A0A2Y9LB74	A0A2Y9Q8T5	Crk-like protein.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.856
CRKL	RAPGEF1	A0A2Y9LB74	A0A2Y9NJ55	Crk-like protein.	Rap guanine nucleotide exchange factor 1 isoform X1.	0.998
CRKL	SHC1	A0A2Y9LB74	A0A2Y9LZK9	Crk-like protein.	SHC-transforming protein 1 isoform X1.	0.739
CRKL	VAV1	A0A2Y9LB74	A0A2Y9LSY4	Crk-like protein.	Proto-oncogene vav isoform X1.	0.604
EPO	CRKL	A0A2Y9PM33	A0A2Y9LB74	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Crk-like protein.	0.507
EPO	GRB2	A0A2Y9PM33	A0A2Y9PJ90	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Growth factor receptor-bound protein 2.	0.618
EPO	IRS2	A0A2Y9PM33	A0A2Y9NC55	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Insulin receptor substrate 2.	0.437
EPO	JAK2	A0A2Y9PM33	A0A2Y9N3T7	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.931
EPO	LOC111165942	A0A2Y9PM33	A0A2Y9LSV2	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Erythropoietin receptor; Receptor for erythropoietin.	0.996
EPO	LYN	A0A2Y9PM33	A0A2Y9LZZ2	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.584