STRINGSTRING
TGIF1 TGIF1 LDLRAD4 LDLRAD4 MAPK1 MAPK1 MTMR4 MTMR4 FST FST NOG NOG CCNC CCNC NEDD8 NEDD8 TGFBR2 TGFBR2 E2F5 E2F5 CDK19 CDK19 IRX3 IRX3 USP9X USP9X IRX5 IRX5 FOXH1 FOXH1 ACVR2B ACVR2B DAND5 DAND5 KXD1 KXD1 AMH AMH ARHGEF18 ARHGEF18 JUNB JUNB BMP2 BMP2 IRX6 IRX6 CBL CBL NCOR1 NCOR1 CHRDL1 CHRDL1 FSTL1 FSTL1 BMPR1A BMPR1A CGN CGN F11R F11R FURIN FURIN GDF2 GDF2 ATP1B4 ATP1B4 PCSK4 PCSK4 UBE2M UBE2M BMP10 BMP10 BMPR2 BMPR2 ITGB5 ITGB5 ITGAV ITGAV PARD3B PARD3B CCNQ CCNQ ACVR1 ACVR1 ACVR1C ACVR1C UBE2D1 UBE2D1 PPM1A PPM1A ZCCHC4 ZCCHC4 INHBB INHBB CCNT2 CCNT2 ITGB6 ITGB6 AMHR2 AMHR2 SP1 SP1 CCNT1 CCNT1 HDAC1 HDAC1 SMAD9 SMAD9 CER1 CER1 ACVR2A ACVR2A ACVR1B ACVR1B RHOA RHOA CCNK CCNK ACVRL1 ACVRL1 SKIL SKIL SNW1 SNW1 RNF111 RNF111 CDK9 CDK9 LTBP1 LTBP1 CDK8 CDK8 TGFB2 TGFB2 PARD3 PARD3 IRX4 IRX4 ZFYVE9 ZFYVE9 PARP1 PARP1 ITGA8 ITGA8 TGFB3 TGFB3 TFDP1 TFDP1 TFDP2 TFDP2 BAMBI BAMBI STRAP STRAP SMAD6 SMAD6 SMAD3 SMAD3 WWTR1 WWTR1 ITGB1 ITGB1 SMAD4 SMAD4 MKX MKX SMAD2 SMAD2 TRIM33 TRIM33 NEDD4L NEDD4L MEIS3 MEIS3 IRX2 IRX2 IRX1 IRX1 TGFB1 TGFB1 LTBP4 LTBP4 E2F4 E2F4 BMPR1B BMPR1B PARD6A PARD6A SMAD7 SMAD7 ITGB3 ITGB3 MAPK3 MAPK3 PPP1R15A PPP1R15A SMAD5 SMAD5 FBN1 FBN1 ITGB8 ITGB8 SMURF1 SMURF1 SMURF2 SMURF2 FKBP1A FKBP1A LTBP3 LTBP3 MEN1 MEN1 RBL1 RBL1 INHBA INHBA DRAP1 DRAP1 LOC111185603 LOC111185603 ZFYVE16 ZFYVE16 TGIF2 TGIF2 RPS27A RPS27A CHRDL2 CHRDL2 STUB1 STUB1 PMEPA1 PMEPA1 PRKCZ PRKCZ SMAD1 SMAD1 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGIF1Homeobox protein TGIF1. (272 aa)
LDLRAD4LOW QUALITY PROTEIN: low-density lipoprotein receptor class A domain-containing protein 4. (322 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1211 aa)
FSTFollistatin isoform X1. (344 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CCNCcyclin-C isoform X2; Belongs to the cyclin family. (283 aa)
NEDD8NEDD8 isoform X1. (98 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
E2F5Transcription factor E2F5 isoform X1. (365 aa)
CDK19Cyclin-dependent kinase 19 isoform X1. (502 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (502 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2559 aa)
IRX5Iroquois-class homeodomain protein IRX-5. (484 aa)
FOXH1Forkhead box protein H1. (360 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (553 aa)
DAND5LOW QUALITY PROTEIN: DAN domain family member 5. (185 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
AMHMuellerian-inhibiting factor. (578 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X1. (1420 aa)
JUNBTranscription factor jun-B. (347 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
IRX6Iroquois-class homeodomain protein IRX-6. (443 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2454 aa)
CHRDL1Chordin-like protein 1 isoform X1. (527 aa)
FSTL1Follistatin-related protein 1. (307 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CGNCingulin isoform X1. (1194 aa)
F11RJunctional adhesion molecule A. (299 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
GDF2Growth/differentiation factor 2. (431 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (779 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
PARD3BPartitioning defective 3 homolog B isoform X1. (1202 aa)
CCNQCyclin-related protein FAM58A isoform X1; Belongs to the cyclin family. (250 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (190 aa)
PPM1AProtein phosphatase 1A. (382 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4 isoform X1. (513 aa)
INHBBInhibin beta B chain. (407 aa)
CCNT2cyclin-T2 isoform X1; Belongs to the cyclin family. (742 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (597 aa)
SP1Transcription factor Sp1. (786 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
CER1Cerberus. (325 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
RHOATransforming protein RhoA. (193 aa)
CCNKcyclin-K; Belongs to the cyclin family. (582 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
SKILSki-like protein isoform X1. (684 aa)
SNW1SNW domain-containing protein 1. (536 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X1. (1028 aa)
CDK9Cyclin-dependent kinase 9 isoform X2; Belongs to the protein kinase superfamily. (488 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1711 aa)
CDK8Cyclin-dependent kinase 8 isoform X1; Belongs to the protein kinase superfamily. (487 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
IRX4LOW QUALITY PROTEIN: iroquois-class homeodomain protein IRX-4. (522 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1062 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
TFDP1Transcription factor. (410 aa)
TFDP2Transcription factor. (447 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
STRAPSerine-threonine kinase receptor-associated protein isoform X1. (350 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MKXHomeobox protein Mohawk isoform X1. (352 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TRIM33LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM33. (1127 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like isoform X1. (1244 aa)
MEIS3Homeobox protein Meis3 isoform X1. (379 aa)
IRX2Iroquois-class homeodomain protein IRX-2 isoform X2. (477 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (476 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1628 aa)
E2F4Transcription factor E2F4 isoform X1. (438 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PPP1R15ALOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 15A. (569 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FBN1Fibrillin-1 isoform X1. (2871 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
MEN1Menin isoform X1. (616 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1073 aa)
INHBAInhibin beta A chain. (425 aa)
DRAP1Dr1-associated corepressor. (205 aa)
LOC111185603Basic proline-rich protein-like. (161 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X1. (1546 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CHRDL2Chordin-like protein 2 isoform X2. (452 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (303 aa)
PMEPA1Protein TMEPAI. (290 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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