STRINGSTRING
TFF3 TFF3 RUNX1 RUNX1 KAT2B KAT2B KDM1A KDM1A TRPS1 TRPS1 POLR2C POLR2C MYB MYB TBPL1 TBPL1 KANK2 KANK2 KDM4B KDM4B MED1 MED1 CARM1 CARM1 ZC3H12D ZC3H12D KANK3 KANK3 ESR1 ESR1 ZC3H12C ZC3H12C GTF2F1 GTF2F1 PGR PGR LOC111168449 LOC111168449 LOC111168524 LOC111168524 LOC111168528 LOC111168528 LOC111168549 LOC111168549 LOC111168445 LOC111168445 LOC111168515 LOC111168515 LOC111168525 LOC111168525 LOC111168529 LOC111168529 POU2F1 POU2F1 JUND JUND LOC111168516 LOC111168516 LOC111168521 LOC111168521 LOC111168526 LOC111168526 LOC111168530 LOC111168530 USF1 USF1 ZC3H12B ZC3H12B LOC111169749 LOC111169749 NCOA3 NCOA3 LOC111168446 LOC111168446 LOC111168460 LOC111168460 LOC111168527 LOC111168527 LOC111168531 LOC111168531 POLR2E POLR2E POLR2B POLR2B POLR2L POLR2L TBP TBP NR5A2 NR5A2 LOC111168443 LOC111168443 LOC111168448 LOC111168448 LOC111168536 LOC111168536 LOC111168544 LOC111168544 LOC111171120 LOC111171120 LOC111171154 LOC111171154 LOC111169315 LOC111169315 ERBB4 ERBB4 LOC111169736 LOC111169736 LOC111169748 LOC111169748 LOC111171155 LOC111171155 CITED1 CITED1 ZFP42 ZFP42 PTGES3 PTGES3 SP1 SP1 CCNT1 CCNT1 FOXA1 FOXA1 NCOA1 NCOA1 HDAC1 HDAC1 GTF2A1L GTF2A1L ZC3H12A ZC3H12A HSP90AA1 HSP90AA1 POLR2H POLR2H YY1 YY1 GTF2F2 GTF2F2 LOC111174638 LOC111174638 PRMT8 PRMT8 LOC111176743 LOC111176743 LOC111176794 LOC111176794 FOS FOS KANK1 KANK1 CDK9 CDK9 NRIP1 NRIP1 TLE3 TLE3 GTF2A1 GTF2A1 KANK4 KANK4 FKBP4 FKBP4 LOC111179105 LOC111179105 GTF2A2 GTF2A2 GATA3 GATA3 HSP90AB1 HSP90AB1 PRMT1 PRMT1 POLR2K POLR2K FOSB FOSB POLR2I POLR2I EBAG9 EBAG9 POLR2J POLR2J LOC111182289 LOC111182289 USF2 USF2 KAT5 KAT5 POLR2G POLR2G CXXC5 CXXC5 LOC111184525 LOC111184525 DDX5 DDX5 POLR2D POLR2D NCOA2 NCOA2 POLR2A POLR2A CHD1 CHD1 CREBBP CREBBP POLR2F POLR2F EP300 EP300 ZNF217 ZNF217 TNRC6B TNRC6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFF3Trefoil factor 3. (80 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TRPS1Zinc finger transcription factor Trps1 isoform X2. (1293 aa)
POLR2CDNA-directed RNA polymerase II subunit RPB3. (275 aa)
MYBTranscriptional activator Myb isoform X3. (761 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2 isoform X1. (857 aa)
KDM4BLysine-specific demethylase 4B isoform X1. (1121 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
CARM1Histone-arginine methyltransferase CARM1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (664 aa)
ZC3H12DProbable ribonuclease ZC3H12D. (495 aa)
KANK3KN motif and ankyrin repeat domain-containing protein 3 isoform X1. (811 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ZC3H12CProbable ribonuclease ZC3H12C isoform X1. (886 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (518 aa)
PGRProgesterone receptor. (936 aa)
LOC111168449Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168524Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168528Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168549Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC111168445Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168515Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111168525Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168529Histone H2B; Belongs to the histone H2B family. (126 aa)
POU2F1POU domain protein. (756 aa)
JUNDTranscription factor jun-D. (345 aa)
LOC111168516Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111168521Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168526Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168530Histone H2B; Belongs to the histone H2B family. (126 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
ZC3H12BProbable ribonuclease ZC3H12B. (836 aa)
LOC111169749Histone H2B; Belongs to the histone H2B family. (126 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
LOC111168446Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168460Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC111168527Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168531Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (112 aa)
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
POLR2LDNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
TBPTATA-box-binding protein. (319 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2 isoform X1. (501 aa)
LOC111168443Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168448Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168536Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC111168544Histone H2B type 1-L-like; Belongs to the histone H2B family. (143 aa)
LOC111171120Late histone H2B.L4-like; Belongs to the histone H2B family. (135 aa)
LOC111171154Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111169315Histone H2B; Belongs to the histone H2B family. (126 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
LOC111169736Histone H2B; Belongs to the histone H2B family. (197 aa)
LOC111169748Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC111171155Histone H2B; Belongs to the histone H2B family. (126 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
ZFP42Zinc finger protein 42 homolog. (299 aa)
PTGES3Prostaglandin E synthase 3 isoform X1. (177 aa)
SP1Transcription factor Sp1. (786 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
GTF2A1LTFIIA-alpha and beta-like factor. (533 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
LOC111174638Histone-arginine methyltransferase CARM1-like isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
PRMT8Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
LOC111176743Histone H2B; Belongs to the histone H2B family. (122 aa)
LOC111176794Histone H2A; Belongs to the histone H2A family. (129 aa)
FOSProto-oncogene c-Fos. (380 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1 isoform X3. (1351 aa)
CDK9Cyclin-dependent kinase 9 isoform X2; Belongs to the protein kinase superfamily. (488 aa)
NRIP1Nuclear receptor-interacting protein 1. (1156 aa)
TLE3Transducin-like enhancer protein 3 isoform X7. (776 aa)
GTF2A1Transcription initiation factor IIA subunit 1. (375 aa)
KANK4KN motif and ankyrin repeat domain-containing protein 4. (1003 aa)
FKBP4Peptidylprolyl isomerase. (458 aa)
LOC111179105Histone H2A; Belongs to the histone H2A family. (128 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
POLR2KDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
FOSBProtein fosB isoform X1. (341 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (132 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells isoform X2. (336 aa)
POLR2JDNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
LOC111182289LOW QUALITY PROTEIN: uroplakin-3b-like protein 1. (253 aa)
USF2Upstream stimulatory factor 2. (347 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
POLR2GDNA-directed RNA polymerase II subunit RPB7 isoform X1. (172 aa)
CXXC5CXXC-type zinc finger protein 5. (321 aa)
LOC111184525Histone H2A; Belongs to the histone H2A family. (128 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
POLR2DDNA-directed RNA polymerase II subunit RPB4. (142 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X1. (1798 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1. (127 aa)
EP300Histone acetyltransferase p300. (2420 aa)
ZNF217Zinc finger protein 217. (1044 aa)
TNRC6BTrinucleotide repeat-containing gene 6B protein isoform X1. (1867 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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