STRINGSTRING
NFKB2 NFKB2 IRAK3 IRAK3 IL1RAP IL1RAP MFSD1 MFSD1 MAP3K20 MAP3K20 PSMC1 PSMC1 NFKBIA NFKBIA PSMB2 PSMB2 USP18 USP18 APP APP HMGB1 HMGB1 TRAF2 TRAF2 MAP3K8 MAP3K8 CUL1 CUL1 IL1B IL1B IL1R2 IL1R2 IL1R1 IL1R1 PSMD9 PSMD9 PSMA7 PSMA7 PELI1 PELI1 IL1RN IL1RN PSME4 PSME4 PSMB6 PSMB6 PSMD11 PSMD11 IL1A IL1A FBXW11 FBXW11 S100B S100B RPS27A RPS27A TAB1 TAB1 RBX1 RBX1 PSMA2 PSMA2 PSMF1 PSMF1 PELI3 PELI3 PSMD12 PSMD12 VWC2 VWC2 PSMA5 PSMA5 PSMD7 PSMD7 PSMB10 PSMB10 PSMB8 PSMB8 NFKB1 NFKB1 LOC111180459 LOC111180459 NFKBIB NFKBIB PSMC4 PSMC4 PSMA4 PSMA4 LOC111176111 LOC111176111 LOC111177777 LOC111177777 PSMB7 PSMB7 LRRC74B LRRC74B KHNYN KHNYN NKIRAS2 NKIRAS2 PSMB3 PSMB3 NKIRAS1 NKIRAS1 TONSL TONSL NLRX1 NLRX1 PSMB1 PSMB1 TAB3 TAB3 S100A12 S100A12 LOC111166421 LOC111166421 LRRC31 LRRC31 SQSTM1 SQSTM1 LRRC71 LRRC71 PSMD13 PSMD13 PSMB4 PSMB4 IRAK1 IRAK1 NLRP6 NLRP6 AGER AGER IRAK2 IRAK2 TOLLIP TOLLIP CASP8 CASP8 LOC111171742 LOC111171742 CCDC71L CCDC71L PSMD4 PSMD4 TAB2 TAB2 PSMD3 PSMD3 NLRC5 NLRC5 KXD1 KXD1 LOC111166275 LOC111166275 PSMD10 PSMD10 GSAP GSAP PSMB11 PSMB11 LRRC14 LRRC14 PSMA1 PSMA1 N4BP1 N4BP1 TNIP2 TNIP2 UBE2N UBE2N PSMC2 PSMC2 PSMC3 PSMC3 RELA RELA SKP1 SKP1 MAP3K3 MAP3K3 LRRC45 LRRC45 MAP2K6 MAP2K6 MAP3K2 MAP3K2 PSMC5 PSMC5 PSMA8 PSMA8 NLRP9 NLRP9 TRAF6 TRAF6 PSMD8 PSMD8 PSMD5 PSMD5 PSMB5 PSMB5 MYD88 MYD88 MAP3K7 MAP3K7 PSME1 PSME1 PSME2 PSME2 PSMB9 PSMB9 LRRC74A LRRC74A PSMD1 PSMD1 IKBKG IKBKG LOC111171267 LOC111171267 PSMD14 PSMD14 BTRC BTRC PELI2 PELI2 PSMC6 PSMC6 PSMA6 PSMA6 PSMA3 PSMA3 CHUK CHUK IKBKB IKBKB PSMD6 PSMD6 IRAK4 IRAK4 LRRC34 LRRC34
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X2. (685 aa)
MFSD1Major facilitator superfamily domain-containing protein 1 isoform X1. (468 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (800 aa)
PSMC126S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
PSMB2Proteasome subunit beta. (201 aa)
USP18Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (321 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
HMGB1High mobility group protein B1. (215 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL1R2Interleukin-1 receptor type 2. (421 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (686 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IL1RNInterleukin-1. (177 aa)
PSME4LOW QUALITY PROTEIN: proteasome activator complex subunit 4. (1845 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (270 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
VWC2Brorin. (319 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB8Proteasome subunit beta. (276 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
LOC111180459Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
LOC111176111Ubiquitin-conjugating enzyme E2 N-like. (152 aa)
LOC111177777LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like. (149 aa)
PSMB7Proteasome subunit beta. (277 aa)
LRRC74BLOW QUALITY PROTEIN: leucine-rich repeat-containing protein 74B. (382 aa)
KHNYNProtein KHNYN. (670 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1. (191 aa)
PSMB3Proteasome subunit beta. (205 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
TONSLTonsoku-like protein isoform X1. (1399 aa)
NLRX1NLR family member X1 isoform X1. (973 aa)
PSMB1Proteasome subunit beta. (241 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
S100A12LOW QUALITY PROTEIN: protein S100-A12; Belongs to the S-100 family. (136 aa)
LOC111166421Proteasome activator complex subunit 3. (254 aa)
LRRC31Leucine-rich repeat-containing protein 31. (492 aa)
SQSTM1Sequestosome-1. (440 aa)
LRRC71Leucine-rich repeat-containing protein 71 isoform X1. (573 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
IRAK2LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase-like 2. (621 aa)
TOLLIPToll-interacting protein isoform X1. (273 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC111171742Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
CCDC71LCoiled-coil domain-containing protein 71L. (237 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
NLRC5Protein NLRC5 isoform X1. (1850 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (196 aa)
LOC111166275Proteasome activator complex subunit 3-like. (165 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
GSAPGamma-secretase-activating protein isoform X1. (854 aa)
PSMB11Proteasome subunit beta. (291 aa)
LRRC14Leucine-rich repeat-containing protein 14 isoform X1. (528 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
N4BP1NEDD4-binding protein 1 isoform X1. (906 aa)
TNIP2TNFAIP3-interacting protein 2 isoform X1. (434 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMC326S proteasome regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (423 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (164 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
LRRC45Leucine-rich repeat-containing protein 45 isoform X1. (703 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
PSMA8Proteasome subunit alpha type. (269 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (989 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
PSMB5Proteasome subunit beta. (263 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
PSMB9Proteasome subunit beta. (219 aa)
LRRC74ALeucine-rich repeat-containing protein 74A. (501 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (954 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
LOC111171267Ubiquitin carboxyl-terminal hydrolase 14-like. (97 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (452 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
LRRC34Leucine-rich repeat-containing protein 34. (452 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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