node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPO | IRS2 | A0A2Y9PM33 | A0A2Y9NC55 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Insulin receptor substrate 2. | 0.437 |
EPO | JAK2 | A0A2Y9PM33 | A0A2Y9N3T7 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.931 |
EPO | LOC111165942 | A0A2Y9PM33 | A0A2Y9LSV2 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Erythropoietin receptor; Receptor for erythropoietin. | 0.996 |
EPO | LYN | A0A2Y9PM33 | A0A2Y9LZZ2 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.584 |
EPO | PIK3CA | A0A2Y9PM33 | A0A2Y9MZW2 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.501 |
EPO | PIK3CB | A0A2Y9PM33 | A0A2Y9NZC3 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.501 |
EPO | PIK3CD | A0A2Y9PM33 | A0A2Y9QGK3 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.501 |
EPO | PIK3CG | A0A2Y9PM33 | A0A2Y9LSJ4 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. | 0.501 |
EPO | PIK3R1 | A0A2Y9PM33 | A0A2Y9Q8T5 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. | 0.504 |
GAB1 | IRS2 | A0A2Y9QCZ2 | A0A2Y9NC55 | GRB2-associated-binding protein 1 isoform X1. | Insulin receptor substrate 2. | 0.470 |
GAB1 | JAK2 | A0A2Y9QCZ2 | A0A2Y9N3T7 | GRB2-associated-binding protein 1 isoform X1. | Tyrosine-protein kinase. | 0.546 |
GAB1 | LOC111165942 | A0A2Y9QCZ2 | A0A2Y9LSV2 | GRB2-associated-binding protein 1 isoform X1. | Erythropoietin receptor; Receptor for erythropoietin. | 0.502 |
GAB1 | LYN | A0A2Y9QCZ2 | A0A2Y9LZZ2 | GRB2-associated-binding protein 1 isoform X1. | Tyrosine-protein kinase. | 0.578 |
GAB1 | PIK3CA | A0A2Y9QCZ2 | A0A2Y9MZW2 | GRB2-associated-binding protein 1 isoform X1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.954 |
GAB1 | PIK3CB | A0A2Y9QCZ2 | A0A2Y9NZC3 | GRB2-associated-binding protein 1 isoform X1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.954 |
GAB1 | PIK3CD | A0A2Y9QCZ2 | A0A2Y9QGK3 | GRB2-associated-binding protein 1 isoform X1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.970 |
GAB1 | PIK3CG | A0A2Y9QCZ2 | A0A2Y9LSJ4 | GRB2-associated-binding protein 1 isoform X1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. | 0.568 |
GAB1 | PIK3R1 | A0A2Y9QCZ2 | A0A2Y9Q8T5 | GRB2-associated-binding protein 1 isoform X1. | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. | 0.986 |
GAB1 | PIK3R5 | A0A2Y9QCZ2 | A0A2Y9Q8V7 | GRB2-associated-binding protein 1 isoform X1. | Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. | 0.507 |
IRS2 | EPO | A0A2Y9NC55 | A0A2Y9PM33 | Insulin receptor substrate 2. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.437 |