16 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa)
	IRF7	Interferon regulatory factor 7 isoform X1. (473 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (531 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
	IRF3	Interferon regulatory factor 3 isoform X1. (464 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
	TICAM2	TIR domain-containing adapter molecule 2. (235 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
	SARM1	Sterile alpha and TIR motif-containing protein 1 isoform X1. (723 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	LOC111187198	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	IRF7	A0A2Y9PPG4	A0A2Y9MFD1	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Interferon regulatory factor 7 isoform X1.	0.404
CD14	LY96	A0A2Y9PPG4	A0A2Y9PZM1	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.983
CD14	TLR4	A0A2Y9PPG4	A0A2Y9NKP1	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.983
IKBKE	IRF3	A0A2Y9Q1P3	A0A2Y9P3N5	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Interferon regulatory factor 3 isoform X1.	0.987
IKBKE	IRF7	A0A2Y9Q1P3	A0A2Y9MFD1	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Interferon regulatory factor 7 isoform X1.	0.956
IKBKE	LY96	A0A2Y9Q1P3	A0A2Y9PZM1	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Lymphocyte antigen 96.	0.551
IKBKE	RPS27A	A0A2Y9Q1P3	A0A2Y9Q1L7	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.531
IKBKE	TANK	A0A2Y9Q1P3	A0A2Y9N2B8	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TRAF family member-associated NF-kappa-B activator isoform X1.	0.987
IKBKE	TBK1	A0A2Y9Q1P3	A0A2Y9NDL9	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Serine/threonine-protein kinase TBK1.	0.996
IKBKE	TICAM1	A0A2Y9Q1P3	A0A2Y9M071	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.530
IKBKE	TICAM2	A0A2Y9Q1P3	A0A2Y9PUA3	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TIR domain-containing adapter molecule 2.	0.678
IKBKE	TLR4	A0A2Y9Q1P3	A0A2Y9NKP1	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.581
IKBKE	TRAF3	A0A2Y9Q1P3	A0A2Y9NC44	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
IKBKE	TRAF5	A0A2Y9Q1P3	A0A2Y9Q0U5	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.805
IRF3	IKBKE	A0A2Y9P3N5	A0A2Y9Q1P3	Interferon regulatory factor 3 isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	0.987
IRF3	IRF7	A0A2Y9P3N5	A0A2Y9MFD1	Interferon regulatory factor 3 isoform X1.	Interferon regulatory factor 7 isoform X1.	0.997
IRF3	LY96	A0A2Y9P3N5	A0A2Y9PZM1	Interferon regulatory factor 3 isoform X1.	Lymphocyte antigen 96.	0.679
IRF3	RPS27A	A0A2Y9P3N5	A0A2Y9Q1L7	Interferon regulatory factor 3 isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.446
IRF3	TANK	A0A2Y9P3N5	A0A2Y9N2B8	Interferon regulatory factor 3 isoform X1.	TRAF family member-associated NF-kappa-B activator isoform X1.	0.821
IRF3	TBK1	A0A2Y9P3N5	A0A2Y9NDL9	Interferon regulatory factor 3 isoform X1.	Serine/threonine-protein kinase TBK1.	0.999