STRINGSTRING
MAPK1 MAPK1 RPS6KB1 RPS6KB1 HGF HGF FOXO3 FOXO3 FGFR3 FGFR3 MAP2K2 MAP2K2 STAT3 STAT3 PIK3R2 PIK3R2 ARAF ARAF SHC1 SHC1 ERBB2 ERBB2 TGFA TGFA SHC3 SHC3 PDGFA PDGFA PDGFRA PDGFRA IL6R IL6R GSK3B GSK3B PDGFD PDGFD HRAS HRAS RAF1 RAF1 FGFR2 FGFR2 KDR KDR SHC2 SHC2 EIF4EBP1 EIF4EBP1 SOS2 SOS2 PIK3CA PIK3CA ERBB3 ERBB3 EIF4E2 EIF4E2 JAK2 JAK2 NRG1 NRG1 SOS1 SOS1 PTEN PTEN PIK3R3 PIK3R3 AKT1 AKT1 KRAS KRAS AKT3 AKT3 RPS6 RPS6 GAS6 GAS6 BRAF BRAF VEGFA VEGFA PDGFC PDGFC EIF4E EIF4E MET MET PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 AXL AXL JAK1 JAK1 BAX BAX BCL2 BCL2 NRAS NRAS NRG2 NRG2 AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB PRKCA PRKCA RPS6KB2 RPS6KB2 GRB2 GRB2 SHC4 SHC4 PDGFRB PDGFRB PLCG1 PLCG1 SRC SRC BAD BAD BCL2L1 BCL2L1 PDGFB PDGFB EGFR EGFR NF1 NF1 BCL2L11 BCL2L11 PIK3R1 PIK3R1 MTOR MTOR IGF1R IGF1R GAB1 GAB1 IGF1 IGF1 PIK3CD PIK3CD IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FOXO3Forkhead box protein O3. (672 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SHC3SHC-transforming protein 3. (588 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (282 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (267 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X1; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
NRASGTPase NRas. (189 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SRCTyrosine-protein kinase. (562 aa)
BADBcl2-associated agonist of cell death. (168 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NF1Neurofibromin isoform X1. (2873 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (288 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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