STRINGSTRING
LOC111163175 LOC111163175 MAPK1 MAPK1 E2F2 E2F2 RPS6KB1 RPS6KB1 ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 MAP2K2 MAP2K2 PIK3R2 PIK3R2 MED1 MED1 ARAF ARAF SHC1 SHC1 PRKACA PRKACA MMP2 MMP2 CARM1 CARM1 ESR1 ESR1 ERBB2 ERBB2 JAG1 JAG1 NCOR1 NCOR1 SHC3 SHC3 MAPK10 MAPK10 NOTCH3 NOTCH3 DLL1 DLL1 GPER1 GPER1 NCOA3 NCOA3 HRAS HRAS MAPK9 MAPK9 NOTCH4 NOTCH4 MAPK8 MAPK8 RAF1 RAF1 MMP9 MMP9 ADCY5 ADCY5 ABCB11 ABCB11 ESR2 ESR2 SHC2 SHC2 CDK4 CDK4 SOS2 SOS2 PIK3CA PIK3CA SP1 SP1 ADCY3 ADCY3 SOS1 SOS1 PIK3R3 PIK3R3 JUN JUN JAG2 JAG2 AKT1 AKT1 LOC111174638 LOC111174638 MDM2 MDM2 KRAS KRAS ADCY6 ADCY6 FOS FOS AKT3 AKT3 CDKN2C CDKN2C MAPK14 MAPK14 BRAF BRAF MAPK13 MAPK13 CDKN1A CDKN1A PRKACB PRKACB CDKN1B CDKN1B NOTCH1 NOTCH1 PIK3CB PIK3CB MAP2K1 MAP2K1 ADCY2 ADCY2 DLL3 DLL3 BAX BAX DLL4 DLL4 BCL2 BCL2 NOTCH2 NOTCH2 NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 HBEGF HBEGF E2F3 E2F3 RPS6KB2 RPS6KB2 GRB2 GRB2 SHC4 SHC4 CCND1 CCND1 SRC SRC ADCY1 ADCY1 BAD BAD E2F1 E2F1 EGFR EGFR ADCY9 ADCY9 MAPK12 MAPK12 PIK3R1 PIK3R1 MTOR MTOR IGF1R IGF1R MAPK11 MAPK11 GNAS GNAS IGF1 IGF1 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MMP272 kDa type IV collagenase. (661 aa)
CARM1Histone-arginine methyltransferase CARM1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (664 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2454 aa)
SHC3SHC-transforming protein 3. (588 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2336 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ABCB11Bile salt export pump isoform X1. (1340 aa)
ESR2Estrogen receptor beta. (558 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SP1Transcription factor Sp1. (786 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1233 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC111174638Histone-arginine methyltransferase CARM1-like isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
DLL3Delta-like protein 3. (586 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SRCTyrosine-protein kinase. (562 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
BADBcl2-associated agonist of cell death. (168 aa)
E2F1Transcription factor E2F1. (437 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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