STRINGSTRING
LOC111163175 LOC111163175 LOC111163016 LOC111163016 MAPK1 MAPK1 LOC111163044 LOC111163044 LOC111163045 LOC111163045 TOP2B TOP2B MLH1 MLH1 BRCA1 BRCA1 PIK3R2 PIK3R2 TOP2A TOP2A REV3L REV3L ERBB2 ERBB2 ATM ATM BIRC3 BIRC3 XIAP XIAP MAP3K5 MAP3K5 FASLG FASLG LOC111168369 LOC111168369 MGST3 MGST3 CASP8 CASP8 GSTO2 GSTO2 ABCC2 ABCC2 FAS FAS GSTO1 GSTO1 PIK3CA PIK3CA CASP3 CASP3 MSH6 MSH6 LOC111174575 LOC111174575 ATP7B ATP7B LOC111172911 LOC111172911 PIK3R3 PIK3R3 AKT1 AKT1 MDM2 MDM2 LOC111174031 LOC111174031 LOC111174197 LOC111174197 AKT3 AKT3 LOC111175930 LOC111175930 MSH2 MSH2 ATP7A ATP7A BAK1 BAK1 GSTA4 GSTA4 BID BID CDKN1A CDKN1A SLC31A1 SLC31A1 POLH POLH MGST1 MGST1 LOC111179919 LOC111179919 PIK3CB PIK3CB ERCC1 ERCC1 LOC111178918 LOC111178918 LOC111180067 LOC111180067 PMAIP1 PMAIP1 BAX BAX LOC111178920 LOC111178920 MGST2 MGST2 BCL2 BCL2 LOC111180543 LOC111180543 AKT2 AKT2 MAPK3 MAPK3 BBC3 BBC3 BIRC5 BIRC5 LOC111183662 LOC111183662 FADD FADD LOC111183661 LOC111183661 MSH3 MSH3 BAD BAD BCL2L1 BCL2L1 PDPK1 PDPK1 CASP9 CASP9 PIK3R1 PIK3R1 APAF1 APAF1 XPA XPA PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
LOC111163016Glutathione S-transferase theta-3-like; Belongs to the GST superfamily. (240 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
LOC111163044LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
LOC111163045Glutathione S-transferase theta-4; Belongs to the GST superfamily. (241 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1620 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (758 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1533 aa)
REV3LDNA polymerase zeta catalytic subunit isoform X1. (3133 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
LOC111168369Baculoviral IAP repeat-containing protein 2. (620 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
GSTO2Glutathione S-transferase omega-2 isoform X1; Belongs to the GST superfamily. (216 aa)
ABCC2Canalicular multispecific organic anion transporter 1. (1483 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
GSTO1Glutathione S-transferase omega-1 isoform X3; Belongs to the GST superfamily. (274 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
LOC111174575Cytochrome c-like. (69 aa)
ATP7BCopper-transporting ATPase 2 isoform X1. (1523 aa)
LOC111172911Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
LOC111174031Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC111174197Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
LOC111175930Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ATP7ACopper-transporting ATPase 1. (1525 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
GSTA4Glutathione S-transferase A4 isoform X1; Belongs to the GST superfamily. (240 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SLC31A1High affinity copper uptake protein 1. (191 aa)
POLHDNA polymerase eta isoform X1. (709 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
LOC111179919Glutathione S-transferase. (225 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
LOC111178918Glutathione S-transferase A2; Belongs to the GST superfamily. (223 aa)
LOC111180067LOW QUALITY PROTEIN: glutathione S-transferase Mu 1-like; Belongs to the GST superfamily. (226 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
LOC111178920Glutathione S-transferase A2-like. (158 aa)
MGST2LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2. (139 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
LOC111180543Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BBC3Bcl-2-binding component 3. (193 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
LOC111183662Glutathione S-transferase P-like isoform X1; Belongs to the GST superfamily. (390 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
LOC111183661Glutathione S-transferase P. (208 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1129 aa)
BADBcl2-associated agonist of cell death. (168 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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