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MSI1 MSI1 GSPT1 GSPT1 SMG1 SMG1 RNGTT RNGTT ACIN1 ACIN1 CPSF3 CPSF3 SRRM1 SRRM1 MSI2 MSI2 RNMT RNMT PABPN1 PABPN1 NUDT21 NUDT21 LOC111165075 LOC111165075 LOC111165798 LOC111165798 PABPC4L PABPC4L NXT2 NXT2 CASC3 CASC3 LOC111165074 LOC111165074 UPF1 UPF1 HBS1L HBS1L PPP2R1B PPP2R1B LOC111169266 LOC111169266 UPF3B UPF3B SMG5 SMG5 FIP1L1 FIP1L1 PPP2R3B PPP2R3B DAZAP1 DAZAP1 DDX39B DDX39B PAPOLB PAPOLB PPP2R2D PPP2R2D NCBP2 NCBP2 PPP2R3C PPP2R3C CSTF2T CSTF2T PPP2CB PPP2CB LOC111170771 LOC111170771 LOC111171014 LOC111171014 CPSF6 CPSF6 PYM1 PYM1 WDR82 WDR82 PPP2R5E PPP2R5E SAP18 SAP18 PABPC4 PABPC4 PPP1CB PPP1CB PNN PNN MAGOH MAGOH UPF3A UPF3A MAGOHB MAGOHB CPSF2 CPSF2 GLE1 GLE1 PAPOLA PAPOLA PPP2R5D PPP2R5D PABPC5 PABPC5 CSTF3 CSTF3 CSTF2 CSTF2 UPF2 UPF2 PABPN1L PABPN1L PPP2R2C PPP2R2C PPP2R3A PPP2R3A RBM8A RBM8A CPSF4 CPSF4 DDX19B DDX19B PPP2R1A PPP2R1A PABPC1 PABPC1 FUS FUS SYMPK SYMPK ETF1 ETF1 PPP2CA PPP2CA WDR33 WDR33 EIF4A3 EIF4A3 PPP1CA PPP1CA CPSF4L CPSF4L PPP2R5B PPP2R5B NXF1 NXF1 CLP1 CLP1 ALYREF ALYREF PPP2R5A PPP2R5A PPP2R2B PPP2R2B LOC111184143 LOC111184143 NXT1 NXT1 LOC111184272 LOC111184272 RNPS1 RNPS1 SMG7 SMG7 CPSF7 CPSF7 SMG6 SMG6 PCF11 PCF11 TARDBP TARDBP PPP2R2A PPP2R2A CSTF1 CSTF1 PAPOLG PAPOLG PPP1CC PPP1CC SSU72 SSU72 PELO PELO NCBP1 NCBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSI1RNA-binding protein Musashi homolog 1 isoform X1. (362 aa)
GSPT1Eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1. (639 aa)
SMG1Serine/threonine-protein kinase SMG1 isoform X1; Belongs to the PI3/PI4-kinase family. (3658 aa)
RNGTTPolynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (596 aa)
ACIN1Apoptotic chromatin condensation inducer in the nucleus isoform X1. (1335 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3 isoform X1. (684 aa)
SRRM1Serine/arginine repetitive matrix protein 1 isoform X1. (918 aa)
MSI2RNA-binding protein Musashi homolog 2 isoform X1. (354 aa)
RNMTmRNA cap guanine-N7 methyltransferase. (477 aa)
PABPN1Polyadenylate-binding protein 2. (306 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
LOC111165075Cleavage and polyadenylation specificity factor subunit 1-like isoform X1. (1092 aa)
LOC111165798Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (169 aa)
PABPC4LPolyadenylate-binding protein 4-like. (370 aa)
NXT2NTF2-related export protein 2 isoform X1. (142 aa)
CASC3Protein CASC3. (703 aa)
LOC111165074Cleavage and polyadenylation specificity factor subunit 1 isoform X1. (1107 aa)
UPF1Regulator of nonsense transcripts 1 isoform X1. (1127 aa)
HBS1LHBS1-like protein isoform X1. (686 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
LOC111169266LOW QUALITY PROTEIN: polyadenylate-binding protein 4-like. (370 aa)
UPF3BRegulator of nonsense transcripts 3B isoform X1. (490 aa)
SMG5Protein SMG5 isoform X1. (1016 aa)
FIP1L1pre-mRNA 3'-end-processing factor FIP1 isoform X1. (604 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (578 aa)
DAZAP1DAZ-associated protein 1 isoform X1. (406 aa)
DDX39BSpliceosome RNA helicase DDX39B. (428 aa)
PAPOLBPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (634 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
CSTF2TCleavage stimulation factor subunit 2 tau variant isoform X1. (626 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC111170771LOW QUALITY PROTEIN: eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like. (632 aa)
LOC111171014Polyadenylate-binding protein 1-like 2. (212 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform X1. (589 aa)
PYM1Partner of Y14 and mago. (203 aa)
WDR82WD repeat-containing protein 82. (313 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
SAP18Histone deacetylase complex subunit SAP18. (172 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PNNPinin. (745 aa)
MAGOHProtein mago nashi homolog. (146 aa)
UPF3ARegulator of nonsense transcripts 3A isoform X5. (572 aa)
MAGOHBProtein mago nashi homolog 2 isoform X1. (148 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
GLE1Nucleoporin GLE1 isoform X1. (698 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (743 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
PABPC5Polyadenylate-binding protein 5. (382 aa)
CSTF3Cleavage stimulation factor subunit 3 isoform X1. (717 aa)
CSTF2Cleavage stimulation factor subunit 2 isoform X1. (599 aa)
UPF2Regulator of nonsense transcripts 2. (1270 aa)
PABPN1LEmbryonic polyadenylate-binding protein 2 isoform X1. (277 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
CPSF4Cleavage and polyadenylation specificity factor subunit 4 isoform X1. (309 aa)
DDX19BATP-dependent RNA helicase DDX19B isoform X2. (479 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
FUSRNA-binding protein FUS isoform X1. (514 aa)
SYMPKSymplekin. (1273 aa)
ETF1Eukaryotic peptide chain release factor subunit 1. (437 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
WDR33pre-mRNA 3' end processing protein WDR33 isoform X1. (1406 aa)
EIF4A3Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CPSF4LPutative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X2. (198 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
NXF1Nuclear RNA export factor 1. (620 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (444 aa)
ALYREFTHO complex subunit 4. (257 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa)
LOC111184143Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (612 aa)
NXT1NTF2-related export protein 1 isoform X1. (222 aa)
LOC111184272Polyadenylate-binding protein 1-like. (339 aa)
RNPS1RNA-binding protein with serine-rich domain 1 isoform X1. (305 aa)
SMG7Protein SMG7 isoform X1. (1216 aa)
CPSF7Cleavage and polyadenylation specificity factor subunit 7 isoform X1. (471 aa)
SMG6Telomerase-binding protein EST1A isoform X1. (1411 aa)
PCF11pre-mRNA cleavage complex 2 protein Pcf11 isoform X1. (1686 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CSTF1Cleavage stimulation factor subunit 1. (431 aa)
PAPOLGpoly(A) polymerase gamma isoform X3. (829 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SSU72RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1. (227 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
NCBP1Nuclear cap-binding protein subunit 1 isoform X1. (790 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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