STRINGSTRING
CRKL CRKL MAPK1 MAPK1 RPS6KB1 RPS6KB1 MYC MYC PAK5 PAK5 ELK1 ELK1 MAP2K2 MAP2K2 MAP2K7 MAP2K7 STAT5A STAT5A LOC111166483 LOC111166483 PIK3R2 PIK3R2 ARAF ARAF ABL2 ABL2 SHC1 SHC1 ERBB2 ERBB2 CBL CBL TGFA TGFA PAK3 PAK3 SHC3 SHC3 MAPK10 MAPK10 GSK3B GSK3B HRAS HRAS MAPK9 MAPK9 MAPK8 MAPK8 RAF1 RAF1 ERBB4 ERBB4 PAK2 PAK2 SHC2 SHC2 EIF4EBP1 EIF4EBP1 SOS2 SOS2 PIK3CA PIK3CA ERBB3 ERBB3 NRG1 NRG1 SOS1 SOS1 PIK3R3 PIK3R3 JUN JUN AKT1 AKT1 KRAS KRAS AKT3 AKT3 BRAF BRAF NRG4 NRG4 NCK1 NCK1 CDKN1A CDKN1A CDKN1B CDKN1B ABL1 ABL1 PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 NRAS NRAS NRG2 NRG2 AKT2 AKT2 MAPK3 MAPK3 PAK4 PAK4 HBEGF HBEGF PRKCB PRKCB CAMK2G CAMK2G PRKCA PRKCA RPS6KB2 RPS6KB2 GRB2 GRB2 SHC4 SHC4 PLCG1 PLCG1 CAMK2A CAMK2A SRC SRC NRG3 NRG3 PAK1 PAK1 BAD BAD CRK CRK CBLB CBLB MAP2K4 MAP2K4 CAMK2D CAMK2D CAMK2B CAMK2B EGFR EGFR AREG AREG PIK3R1 PIK3R1 MTOR MTOR NCK2 NCK2 EREG EREG GAB1 GAB1 PIK3CD PIK3CD BTC BTC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
ABL2Tyrosine-protein kinase. (1174 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
SHC3SHC-transforming protein 3. (588 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
NCK1Cytoplasmic protein. (377 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRASGTPase NRas. (189 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PRKCBProtein kinase C. (689 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
SRCTyrosine-protein kinase. (562 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
AREGAmphiregulin isoform X1. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
NCK2Cytoplasmic protein. (376 aa)
EREGProepiregulin. (163 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
BTCProbetacellulin. (178 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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