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AGTR1 AGTR1 MAPK1 MAPK1 OPRD1 OPRD1 ATP2B1 ATP2B1 ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 MYLK3 MYLK3 ADRA2C ADRA2C NFATC4 NFATC4 ROCK2 ROCK2 PLCB1 PLCB1 SLC25A31 SLC25A31 GNAI1 GNAI1 PIK3CG PIK3CG INSR INSR IRS4 IRS4 PLCB4 PLCB4 MAP2K2 MAP2K2 GNA11 GNA11 FXYD2 FXYD2 MEF2D MEF2D LOC111166987 LOC111166987 PLN PLN CREB3L4 CREB3L4 ATP1B1 ATP1B1 LOC111166986 LOC111166986 PDE3B PDE3B MRVI1 MRVI1 LOC111166538 LOC111166538 GUCY1A2 GUCY1A2 CACNA1S CACNA1S CREB3L3 CREB3L3 NPR1 NPR1 SLC25A6 SLC25A6 SLC25A5 SLC25A5 PPP1R12A PPP1R12A CACNA1F CACNA1F NFATC1 NFATC1 ATP1B4 ATP1B4 TRPC6 TRPC6 CNGA1 CNGA1 ADRA1B ADRA1B ATF6B ATF6B IRS1 IRS1 RAF1 RAF1 PPP3CC PPP3CC ADCY5 ADCY5 GNA12 GNA12 NPPC NPPC SLC8A3 SLC8A3 CREB1 CREB1 ATP2B3 ATP2B3 KCNMB4 KCNMB4 ADRB1 ADRB1 ADRA2A ADRA2A SLC25A4 SLC25A4 ITPR1 ITPR1 KNG1 KNG1 KCNMB2 KCNMB2 GNAI2 GNAI2 ADCY3 ADCY3 PRKCE PRKCE CACNA1D CACNA1D VDAC3 VDAC3 ADRB3 ADRB3 PRKG1 PRKG1 ATF2 ATF2 PPP1CB PPP1CB RHOA RHOA AKT1 AKT1 IRS2 IRS2 BDKRB2 BDKRB2 NOS3 NOS3 ITPR2 ITPR2 ADCY6 ADCY6 CACNA1C CACNA1C KCNJ8 KCNJ8 GNAQ GNAQ RGS2 RGS2 AKT3 AKT3 SLC8A1 SLC8A1 CALML4 CALML4 EDNRB EDNRB SRF SRF CALM1 CALM1 GUCY1A3 GUCY1A3 PDE3A PDE3A ATP1A1 ATP1A1 CREB3L2 CREB3L2 MAP2K1 MAP2K1 ITPR3 ITPR3 ADCY2 ADCY2 VASP VASP ATP1B3 ATP1B3 GUCY1B3 GUCY1B3 PPP3CA PPP3CA NFATC3 NFATC3 CREB5 CREB5 GTF2I GTF2I PLCB2 PLCB2 ROCK1 ROCK1 GNAI3 GNAI3 ATP1A3 ATP1A3 AKT2 AKT2 MAPK3 MAPK3 SLC8A2 SLC8A2 GNA13 GNA13 PPIF PPIF PPP1CA PPP1CA LOC111181964 LOC111181964 KCNMA1 KCNMA1 GTF2IRD1 GTF2IRD1 PPP3CB PPP3CB ATP2A1 ATP2A1 PLCB3 PLCB3 VDAC1 VDAC1 ADRA1D ADRA1D CREB3L1 CREB3L1 ADRB2 ADRB2 MYL9 MYL9 PDE2A PDE2A ADCY1 ADCY1 ADORA1 ADORA1 INS INS VDAC2 VDAC2 ADRA1A ADRA1A ATP2B4 ATP2B4 BAD BAD ATP1B2 ATP1B2 GATA4 GATA4 PDE5A PDE5A ATF4 ATF4 MYLK2 MYLK2 ATP2A3 ATP2A3 ADCY9 ADCY9 KCNMB1 KCNMB1 PPP1CC PPP1CC PIK3R5 PIK3R5 PIK3R6 PIK3R6 CALML6 CALML6 NPPB NPPB MEF2A MEF2A ADRA2B ADRA2B PPP3R1 PPP3R1 PRKG2 PRKG2 EDNRA EDNRA NFATC2 NFATC2 ATP2A2 ATP2A2 PPP3R2 PPP3R2 NPPA NPPA NPR2 NPR2 CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADRA2Calpha-2C adrenergic receptor. (458 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (107 aa)
MEF2DMyocyte-specific enhancer factor 2D isoform X1. (512 aa)
LOC111166987Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
LOC111166986Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PDE3BPhosphodiesterase. (1120 aa)
MRVI1Protein MRVI1 isoform X1. (902 aa)
LOC111166538Myocyte-specific enhancer factor 2B-like isoform X1. (499 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (726 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
NPR1Guanylate cyclase. (1065 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
TRPC6Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
CNGA1cGMP-gated cation channel alpha-1. (689 aa)
ADRA1Balpha-1B adrenergic receptor. (518 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X2. (279 aa)
NPPCC-type natriuretic peptide. (126 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1248 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
PRKCEProtein kinase C. (746 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (283 aa)
ADRB3LOW QUALITY PROTEIN: beta-3 adrenergic receptor. (391 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
KCNJ8ATP-sensitive inward rectifier potassium channel 8. (424 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X7; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1004 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SRFSerum response factor isoform X2. (535 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
PDE3APhosphodiesterase. (1137 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
GTF2IGeneral transcription factor II-I isoform X1. (999 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
KCNMA1LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1. (1320 aa)
GTF2IRD1General transcription factor II-I repeat domain-containing protein 1 isoform X1. (974 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
ADRA1Dalpha-1D adrenergic receptor isoform X1. (569 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
PDE2APhosphodiesterase. (971 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
BADBcl2-associated agonist of cell death. (168 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
GATA4Transcription factor GATA-4 isoform X1. (437 aa)
PDE5APhosphodiesterase. (865 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
NPPBNatriuretic peptides B. (132 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (501 aa)
ADRA2Balpha-2B adrenergic receptor. (446 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
PRKG2cGMP-dependent protein kinase. (792 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
NPPANatriuretic peptides A. (152 aa)
NPR2Guanylate cyclase. (1056 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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