STRINGSTRING
GNGT2 GNGT2 CRKL CRKL CDC42 CDC42 CCL19 CCL19 FGR FGR MAPK1 MAPK1 CCL21 CCL21 LOC111163731 LOC111163731 GNG4 GNG4 GRK3 GRK3 LOC111163732 LOC111163732 ADCY4 ADCY4 CCR4 CCR4 ADCY8 ADCY8 CCL27 CCL27 FOXO3 FOXO3 ADCY7 ADCY7 CCL5 CCL5 LOC111163733 LOC111163733 LOC111163186 LOC111163186 CCL22 CCL22 CX3CL1 CX3CL1 ROCK2 ROCK2 PLCB1 PLCB1 GNAI1 GNAI1 PIK3CG PIK3CG VAV1 VAV1 PLCB4 PLCB4 CCR10 CCR10 LOC111166483 LOC111166483 CCR7 CCR7 STAT3 STAT3 CCL17 CCL17 GNG14 GNG14 PIK3R2 PIK3R2 SHC1 SHC1 PRKACA PRKACA LYN LYN XCL1 XCL1 CXCR3 CXCR3 CCR6 CCR6 CXCR5 CXCR5 JAK3 JAK3 SHC3 SHC3 CCL25 CCL25 CCR8 CCR8 WAS WAS CX3CR1 CX3CR1 GSK3B GSK3B GRK6 GRK6 HRAS HRAS RAF1 RAF1 CCL20 CCL20 ADCY5 ADCY5 STAT1 STAT1 CXCL12 CXCL12 GNG7 GNG7 IKBKG IKBKG SHC2 SHC2 STAT2 STAT2 SOS2 SOS2 PIK3CA PIK3CA CHUK CHUK IKBKB IKBKB CXCR4 CXCR4 CXCR2 CXCR2 LOC111171817 LOC111171817 GNB4 GNB4 CCR3 CCR3 CCR1 CCR1 XCR1 XCR1 GNAI2 GNAI2 JAK2 JAK2 ADCY3 ADCY3 SOS1 SOS1 TIAM1 TIAM1 LOC111174480 LOC111174480 GNG2 GNG2 PIK3R3 PIK3R3 PRKCD PRKCD NFKBIA NFKBIA RHOA RHOA AKT1 AKT1 CXCR6 CXCR6 RAP1B RAP1B KRAS KRAS ADCY6 ADCY6 VAV2 VAV2 CCR2 CCR2 CCR9 CCR9 GNAQ GNAQ AKT3 AKT3 PARD3 PARD3 LOC111176690 LOC111176690 GNB5 GNB5 BRAF BRAF LOC111177332 LOC111177332 PRKACB PRKACB PLCG2 PLCG2 BCAR1 BCAR1 GRK7 GRK7 PIK3CB PIK3CB MAP2K1 MAP2K1 NFKBIB NFKBIB GNG5 GNG5 RAP1A RAP1A VAV3 VAV3 GNG12 GNG12 NFKB1 NFKB1 ADCY2 ADCY2 ELMO1 ELMO1 GNG11 GNG11 GSK3A GSK3A NCF1 NCF1 PLCB2 PLCB2 ROCK1 ROCK1 NRAS NRAS GNAI3 GNAI3 CCL26 CCL26 RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 GNB2 GNB2 GNG8 GNG8 GNGT1 GNGT1 PRKCB PRKCB ITK ITK CXCL14 CXCL14 GRK2 GRK2 GRB2 GRB2 SHC4 SHC4 RAC1 RAC1 PLCG1 PLCG1 LOC111184310 LOC111184310 CCL24 CCL24 PLCB3 PLCB3 RELA RELA SRC SRC HCK HCK GNG13 GNG13 ADCY1 ADCY1 RASGRP2 RASGRP2 PAK1 PAK1 BAD BAD CRK CRK GNG3 GNG3 RAC2 RAC2 DOCK2 DOCK2 LOC111185731 LOC111185731 LOC111185794 LOC111185794 ARRB1 ARRB1 ARRB2 ARRB2 CXCL16 CXCL16 ADCY9 ADCY9 PTK2B PTK2B PREX1 PREX1 PPBP PPBP CXCL10 CXCL10 LOC111185888 LOC111185888 CCL28 CCL28 LOC111187662 LOC111187662 PIK3R1 PIK3R1 PIK3R5 PIK3R5 PIK3R6 PIK3R6 PRKCZ PRKCZ LOC111187576 LOC111187576 LOC111187580 LOC111187580 CXCL8 CXCL8 CXCL11 CXCL11 GNB1 GNB1 PIK3CD PIK3CD CXCL13 CXCL13 LOC111187648 LOC111187648 LOC111187591 LOC111187591 CXCL9 CXCL9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
CCL19C-C motif chemokine. (159 aa)
FGRTyrosine-protein kinase. (526 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
LOC111163731C-C motif chemokine. (93 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
LOC111163732C-C motif chemokine. (92 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
CCL27LOW QUALITY PROTEIN: C-C motif chemokine 27. (117 aa)
FOXO3Forkhead box protein O3. (672 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
CCL5C-C motif chemokine. (91 aa)
LOC111163733C-C motif chemokine. (90 aa)
LOC111163186Uncharacterized protein LOC111163186. (87 aa)
CCL22C-C motif chemokine. (93 aa)
CX3CL1Fractalkine. (469 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CCR10C-C chemokine receptor type 10; Belongs to the G-protein coupled receptor 1 family. (376 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CCL17C-C motif chemokine. (109 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (101 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LYNTyrosine-protein kinase. (518 aa)
XCL1Lymphotactin. (111 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CXCR5C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
SHC3SHC-transforming protein 3. (588 aa)
CCL25C-C motif chemokine 25. (153 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (582 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CCL20C-C motif chemokine. (97 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
STAT2Signal transducer and activator of transcription. (911 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CXCR2C-X-C chemokine receptor type 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC111171817C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CCR1C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
LOC111174480C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CXCR6C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
CCR2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
CCR9C-C chemokine receptor type 9 isoform X1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
LOC111176690Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
LOC111177332Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (551 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CCL26C-C motif chemokine 26. (94 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKCBProtein kinase C. (689 aa)
ITKTyrosine-protein kinase. (620 aa)
CXCL14C-X-C motif chemokine 14. (99 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LOC111184310Tyrosine-protein kinase. (369 aa)
CCL24C-C motif chemokine 24. (119 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SRCTyrosine-protein kinase. (562 aa)
HCKTyrosine-protein kinase. (506 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X1. (684 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
DOCK2Dedicator of cytokinesis protein 2 isoform X1; Belongs to the DOCK family. (1828 aa)
LOC111185731C-C motif chemokine. (99 aa)
LOC111185794C-C motif chemokine. (97 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
CXCL16C-X-C motif chemokine 16 isoform X1. (316 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1. (1653 aa)
PPBPC-X-C motif chemokine. (119 aa)
CXCL10C-X-C motif chemokine. (103 aa)
LOC111185888C-C motif chemokine. (99 aa)
CCL28C-C motif chemokine. (178 aa)
LOC111187662C-X-C motif chemokine. (104 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
LOC111187576C-X-C motif chemokine. (104 aa)
LOC111187580C-X-C motif chemokine. (112 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
CXCL11C-X-C motif chemokine 11. (100 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
LOC111187648C-X-C motif chemokine 6-like. (113 aa)
LOC111187591C-X-C motif chemokine. (104 aa)
CXCL9C-X-C motif chemokine. (160 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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