STRINGSTRING
MAPK1 MAPK1 IFNGR2 IFNGR2 EGLN1 EGLN1 RPS6KB1 RPS6KB1 TEK TEK INSR INSR PFKP PFKP MKNK2 MKNK2 MAP2K2 MAP2K2 IFNGR1 IFNGR1 STAT3 STAT3 PIK3R2 PIK3R2 ERBB2 ERBB2 TIMP1 TIMP1 LOC111167379 LOC111167379 HK2 HK2 IL6R IL6R HK3 HK3 PDHA1 PDHA1 ENO4 ENO4 ARNT ARNT LOC111169978 LOC111169978 PDK1 PDK1 LOC111170450 LOC111170450 EIF4EBP1 EIF4EBP1 EGLN3 EGLN3 TFRC TFRC HIF1A HIF1A PIK3CA PIK3CA PFKM PFKM EIF4E2 EIF4E2 FLT1 FLT1 PDHB PDHB PIK3R3 PIK3R3 ANGPT2 ANGPT2 AKT1 AKT1 IFNG IFNG LTBR LTBR MKNK1 MKNK1 NOS3 NOS3 ENO2 ENO2 LDHB LDHB AKT3 AKT3 RPS6 RPS6 TLR4 TLR4 SLC2A1 SLC2A1 VEGFA VEGFA PFKFB3 PFKFB3 CUL2 CUL2 CDKN1A CDKN1A GAPDH GAPDH CDKN1B CDKN1B EIF4E EIF4E LDHA LDHA PLCG2 PLCG2 TF TF PIK3CB PIK3CB MAP2K1 MAP2K1 EGLN2 EGLN2 PGK1 PGK1 PDHA2 PDHA2 NFKB1 NFKB1 LOC111179199 LOC111179199 ANGPT1 ANGPT1 BCL2 BCL2 LOC111179859 LOC111179859 AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB EDN1 EDN1 CAMK2G CAMK2G PRKCA PRKCA RPS6KB2 RPS6KB2 HKDC1 HKDC1 ALDOA ALDOA EPO EPO PLCG1 PLCG1 HK1 HK1 SERPINE1 SERPINE1 ANGPT4 ANGPT4 RELA RELA CAMK2A CAMK2A INS INS CAMK2D CAMK2D CREBBP CREBBP CAMK2B CAMK2B RBX1 RBX1 EGFR EGFR ELOC ELOC ALDOC ALDOC LOC111185989 LOC111185989 ENO3 ENO3 ELOB ELOB PFKL PFKL EP300 EP300 PIK3R1 PIK3R1 ENO1 ENO1 MTOR MTOR IGF1R IGF1R IGF1 IGF1 NPPA NPPA PIK3CD PIK3CD HMOX1 HMOX1 ALDOB ALDOB IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
IFNGR2Interferon gamma receptor 2. (364 aa)
EGLN1Egl nine homolog 1. (439 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (809 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (463 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TIMP1Metalloproteinase inhibitor 1. (257 aa)
LOC111167379L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
HK2Hexokinase-2. (917 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
HK3Hexokinase-3 isoform X1. (924 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
ENO4Enolase 4. (616 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
LOC111169978Von Hippel-Lindau disease tumor suppressor. (166 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
LOC111170450Cytochrome b-245 heavy chain isoform X1. (570 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
EGLN3Egl nine homolog 3. (239 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (282 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ENO2Gamma-enolase. (434 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (267 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (526 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X1; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
LDHAL-lactate dehydrogenase. (418 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TFSerotransferrin; Belongs to the transferrin family. (702 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGLN2Egl nine homolog 2. (402 aa)
PGK1Phosphoglycerate kinase. (417 aa)
PDHA2Pyruvate dehydrogenase E1 component alpha subunit. (387 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
LOC111179199Serotransferrin-like; Belongs to the transferrin family. (706 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
LOC111179859L-lactate dehydrogenase C chain-like isoform X2. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
EDN1Endothelin-1. (202 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (918 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ANGPT4Angiopoietin-4. (498 aa)
RELATranscription factor p65 isoform X1. (562 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ELOCelongin-C; Belongs to the SKP1 family. (112 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
ENO3Beta-enolase isoform X1. (510 aa)
ELOBelongin-B. (118 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ENO1Alpha-enolase isoform X1. (450 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
NPPANatriuretic peptides A. (152 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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