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IMPA2 IMPA2 MTMR4 MTMR4 PLCD1 PLCD1 PI4KA PI4KA DGKE DGKE MTMR3 MTMR3 SYNJ1 SYNJ1 LOC111163199 LOC111163199 IMPAD1 IMPAD1 PLCB1 PLCB1 CDS2 CDS2 PLCB4 PLCB4 DGKQ DGKQ PIK3C2A PIK3C2A PIP4K2B PIP4K2B PIK3R2 PIK3R2 IMPA1 IMPA1 MTM1 MTM1 SYNJ2 SYNJ2 OCRL OCRL PIP5K1C PIP5K1C CDS1 CDS1 PIK3C3 PIK3C3 PIP5K1A PIP5K1A PI4KB PI4KB MTMR1 MTMR1 MTMR2 MTMR2 INPP1 INPP1 IPPK IPPK PI4K2B PI4K2B DGKD DGKD INPP5F INPP5F INPP5A INPP5A INPPL1 INPPL1 PI4K2A PI4K2A MTMR14 MTMR14 PLCD3 PLCD3 IPMK IPMK PLCD4 PLCD4 DGKG DGKG INPP5D INPP5D DGKA DGKA PIK3CA PIK3CA ITPR1 ITPR1 PIKFYVE PIKFYVE IP6K1 IP6K1 PIP5K1B PIP5K1B IP6K2 IP6K2 MTMR7 MTMR7 MTMR6 MTMR6 PLCE1 PLCE1 PTEN PTEN SACM1L SACM1L INPP5B INPP5B DGKH DGKH PIK3R3 PIK3R3 PIP4K2C PIP4K2C ITPR2 ITPR2 ITPK1 ITPK1 PLCZ1 PLCZ1 ITPKB ITPKB CALML4 CALML4 PIK3C2G PIK3C2G IP6K3 IP6K3 INPP5E INPP5E CALM1 CALM1 PIP4K2A PIP4K2A PLCG2 PLCG2 PIK3CB PIK3CB PIP4P2 PIP4P2 DGKI DGKI ITPR3 ITPR3 ITPKC ITPKC PLCB2 PLCB2 LOC111180171 LOC111180171 PPIP5K1 PPIP5K1 PIP4P1 PIP4P1 CDIPT CDIPT PRKCB PRKCB PRKCA PRKCA DGKB DGKB ITPKA ITPKA PPIP5K2 PPIP5K2 PLCG1 PLCG1 PLCB3 PLCB3 DGKZ DGKZ PIK3C2B PIK3C2B PIK3R1 PIK3R1 CALML6 CALML6 PIK3CD PIK3CD LOC111187436 LOC111187436 INPP4B INPP4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMPA2Inositol-1-monophosphatase. (288 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1211 aa)
PLCD1Phosphoinositide phospholipase C. (817 aa)
PI4KAPhosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family. (2149 aa)
DGKEDiacylglycerol kinase. (578 aa)
MTMR3Myotubularin-related protein 3 isoform X1. (1202 aa)
SYNJ1Synaptojanin-1 isoform X2. (1592 aa)
LOC111163199LOW QUALITY PROTEIN: phosphatidylinositide phosphatase SAC1-like. (535 aa)
IMPAD1Inositol monophosphatase 3. (359 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
DGKQDiacylglycerol kinase. (976 aa)
PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1; Belongs to the PI3/PI4-kinase family. (1711 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
IMPA1Inositol-1-monophosphatase. (277 aa)
MTM1Myotubularin isoform X1. (603 aa)
SYNJ2Synaptojanin-2 isoform X1. (1478 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform X1. (893 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
PI4KBPhosphatidylinositol 4-kinase beta isoform X1; Belongs to the PI3/PI4-kinase family. (832 aa)
MTMR1Myotubularin-related protein 1 isoform X1. (685 aa)
MTMR2Myotubularin-related protein 2 isoform X1. (643 aa)
INPP1Inositol polyphosphate 1-phosphatase. (402 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (547 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2-beta. (488 aa)
DGKDDiacylglycerol kinase. (1237 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X1. (1173 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1. (534 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1264 aa)
PI4K2APhosphatidylinositol 4-kinase type 2-alpha. (479 aa)
MTMR14Myotubularin-related protein 14 isoform X1. (648 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (419 aa)
PLCD4Phosphoinositide phospholipase C. (821 aa)
DGKGDiacylglycerol kinase. (835 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
DGKADiacylglycerol kinase. (762 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
PIKFYVE1-phosphatidylinositol 3-phosphate 5-kinase isoform X1. (2110 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
MTMR7Myotubularin-related protein 7 isoform X1. (660 aa)
MTMR6Myotubularin-related protein 6. (622 aa)
PLCE1Phosphoinositide phospholipase C. (1811 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SACM1LPhosphatidylinositide phosphatase SAC1 isoform X1. (587 aa)
INPP5BType II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1. (994 aa)
DGKHDiacylglycerol kinase. (1247 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase isoform X1. (419 aa)
PLCZ1Phosphoinositide phospholipase C. (502 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
PIK3C2GPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (1483 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (389 aa)
INPP5E72 kDa inositol polyphosphate 5-phosphatase. (627 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (461 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
DGKIDiacylglycerol kinase. (1079 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (685 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
LOC111180171LOW QUALITY PROTEIN: phosphatidylinositide phosphatase SAC2-like. (615 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1594 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (373 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
DGKBDiacylglycerol kinase. (803 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (460 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1243 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
DGKZDiacylglycerol kinase. (1210 aa)
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
LOC111187436Type I inositol 3,4-bisphosphate 4-phosphatase isoform X4. (974 aa)
INPP4BType II inositol 3,4-bisphosphate 4-phosphatase isoform X2. (754 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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