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| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | OPRD1 | Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | SMPD2 | LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase 2. (423 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1. (1530 aa) |
| | ROCK2 | Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | CERS4 | Ceramide synthase 4. (393 aa) |
| | S1PR4 | Sphingosine 1-phosphate receptor 4. (464 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | S1PR5 | Sphingosine 1-phosphate receptor 5 isoform X1. (510 aa) |
| | S1PR2 | Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | CERS1 | Ceramide synthase 1 isoform X1. (350 aa) |
| | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma. (86 aa) |
| | NSMAF | Protein FAN isoform X1. (920 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | SPTLC1 | Serine palmitoyltransferase 1. (473 aa) |
| | S1PR3 | Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa) |
| | FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (258 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | PPP2R3B | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (578 aa) |
| | CTSD | Cathepsin D; Belongs to the peptidase A1 family. (411 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2. (365 aa) |
| | GNA12 | Guanine nucleotide-binding protein subunit alpha-12 isoform X2. (279 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (399 aa) |
| | ASAH2 | Neutral ceramidase. (757 aa) |
| | PPP2R3C | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ASAH1 | Acid ceramidase isoform X1; Belongs to the acid ceramidase family. (395 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (445 aa) |
| | CERS5 | Ceramide synthase 5 isoform X1. (401 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PLD1 | Phospholipase. (1151 aa) |
| | KNG1 | Kininogen-1 isoform X1. (627 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | PRKCE | Protein kinase C. (746 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1. (413 aa) |
| | CERS6 | Ceramide synthase 6 isoform X1. (392 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | BDKRB2 | B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | SPTLC2 | Serine palmitoyltransferase 2 isoform X1. (561 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (276 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa) |
| | KRAS | GTPase KRas. (188 aa) |
| | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1. (337 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | DEGS1 | Sphingolipid delta(4)-desaturase DES1 isoform X1. (323 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | S1PR1 | Sphingosine 1-phosphate receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (223 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | PPP2R3A | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (233 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | SPHK2 | Sphingosine kinase 2 isoform X1. (655 aa) |
| | GNA13 | Guanine nucleotide-binding protein subunit alpha-13. (377 aa) |
| | PRKCB | Protein kinase C. (689 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
| | SPHK1 | Sphingosine kinase 1 isoform X2. (484 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (192 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa) |
| | MS4A2 | High affinity immunoglobulin epsilon receptor subunit beta. (243 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa) |
| | SPTLC3 | Serine palmitoyltransferase 3 isoform X2. (502 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa) |
| | GAB2 | GRB2-associated-binding protein 2 isoform X1. (678 aa) |
| | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (456 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | CERS3 | Ceramide synthase 3. (389 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
