STRINGSTRING
AGTR1 AGTR1 MAPK1 MAPK1 AGT AGT KITLG KITLG ADCY4 ADCY4 ADCY8 ADCY8 FYN FYN ADCY7 ADCY7 DGKE DGKE PLCB1 PLCB1 PIK3CG PIK3CG INSR INSR PLCB4 PLCB4 MAP2K2 MAP2K2 DGKQ DGKQ DNM2 DNM2 LOC111166071 LOC111166071 RRAS2 RRAS2 GRM1 GRM1 PIK3R2 PIK3R2 FCER1G FCER1G SHC1 SHC1 LPAR2 LPAR2 DNM3 DNM3 PIP5K1C PIP5K1C SHC3 SHC3 GRM6 GRM6 ARF1 ARF1 PDGFA PDGFA KIT KIT PDGFRA PDGFRA FCER1A FCER1A PIP5K1A PIP5K1A RALB RALB PDGFD PDGFD SYK SYK HRAS HRAS GRM7 GRM7 LOC111171236 LOC111171236 RAF1 RAF1 DGKD DGKD ADCY5 ADCY5 GNA12 GNA12 AGPAT1 AGPAT1 PLPP2 PLPP2 SHC2 SHC2 ARF6 ARF6 AVPR1A AVPR1A RAPGEF4 RAPGEF4 DGKG DGKG DGKA DGKA SOS2 SOS2 PIK3CA PIK3CA RAPGEF3 RAPGEF3 PLD1 PLD1 CXCR2 CXCR2 LOC111171817 LOC111171817 PIP5K1B PIP5K1B ADCY3 ADCY3 SOS1 SOS1 LPAR6 LPAR6 DGKH DGKH PIK3R3 PIK3R3 GRM2 GRM2 AGPAT5 AGPAT5 RHOA RHOA AKT1 AKT1 RHEB RHEB PLPP3 PLPP3 KRAS KRAS ADCY6 ADCY6 LOC111176674 LOC111176674 AKT3 AKT3 RALGDS RALGDS TSC1 TSC1 DNM1 DNM1 LPAR1 LPAR1 PDGFC PDGFC MRAS MRAS LPAR3 LPAR3 AGPAT2 AGPAT2 PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 DGKI DGKI GRM4 GRM4 LPAR4 LPAR4 PTGFR PTGFR ADCY2 ADCY2 RRAS RRAS PLA2G4F PLA2G4F PLCB2 PLCB2 NRAS NRAS CYTH3 CYTH3 PLA2G4E PLA2G4E AKT2 AKT2 MAPK3 MAPK3 SPHK2 SPHK2 CYTH2 CYTH2 GNA13 GNA13 LOC111182367 LOC111182367 PRKCA PRKCA DGKB DGKB SPHK1 SPHK1 GRB2 GRB2 SHC4 SHC4 PDGFRB PDGFRB GRM3 GRM3 LOC111182370 LOC111182370 PLCG1 PLCG1 PLCB3 PLCB3 AVP AVP CYTH1 CYTH1 LOC111182578 LOC111182578 MS4A2 MS4A2 DGKZ DGKZ ADCY1 ADCY1 INS INS F2 F2 PLD2 PLD2 RALA RALA AVPR1B AVPR1B PDGFB PDGFB EGFR EGFR PLA2G4A PLA2G4A GRM5 GRM5 GAB2 GAB2 TSC2 TSC2 F2R F2R ADCY9 ADCY9 PTK2B PTK2B AGPAT3 AGPAT3 PIK3R1 PIK3R1 PIK3R5 PIK3R5 PIK3R6 PIK3R6 CYTH4 CYTH4 MTOR MTOR CXCL8 CXCL8 PLPP1 PLPP1 GAB1 GAB1 GNAS GNAS PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
KITLGKit ligand isoform X1. (295 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
DGKEDiacylglycerol kinase. (578 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
DGKQDiacylglycerol kinase. (976 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
RRAS2Ras-related protein R-Ras2. (204 aa)
GRM1Metabotropic glutamate receptor 1. (1195 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (873 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
SHC3SHC-transforming protein 3. (588 aa)
GRM6Metabotropic glutamate receptor 6. (870 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (258 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
RALBRas-related protein Ral-B. (206 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
SYKTyrosine-protein kinase. (626 aa)
HRASGTPase HRas isoform X1. (189 aa)
GRM7Metabotropic glutamate receptor 7. (769 aa)
LOC111171236Metabotropic glutamate receptor 7-like. (192 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
DGKDDiacylglycerol kinase. (1237 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X2. (279 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
PLPP2LOW QUALITY PROTEIN: phospholipid phosphatase 2. (345 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
DGKGDiacylglycerol kinase. (835 aa)
DGKADiacylglycerol kinase. (762 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
PLD1Phospholipase. (1151 aa)
CXCR2C-X-C chemokine receptor type 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC111171817C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
DGKHDiacylglycerol kinase. (1247 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
GRM2Metabotropic glutamate receptor 2. (872 aa)
AGPAT51-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1. (382 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RHEBGTP-binding protein Rheb. (184 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
LOC111176674Lysophosphatidic acid receptor 5-like; Belongs to the G-protein coupled receptor 1 family. (367 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
TSC1Hamartin. (1169 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
MRASRas-related protein M-Ras. (208 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DGKIDiacylglycerol kinase. (1079 aa)
GRM4Metabotropic glutamate receptor 4 isoform X1. (957 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PTGFRProstaglandin F2-alpha receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
PLA2G4FPhospholipase A2. (849 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
CYTH3Cytohesin-3 isoform X1. (400 aa)
PLA2G4EPhospholipase A2. (868 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
CYTH2Cytohesin-2. (399 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
LOC111182367Metabotropic glutamate receptor 8-like. (468 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
DGKBDiacylglycerol kinase. (803 aa)
SPHK1Sphingosine kinase 1 isoform X2. (484 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
GRM3LOW QUALITY PROTEIN: metabotropic glutamate receptor 3. (879 aa)
LOC111182370Metabotropic glutamate receptor 8. (407 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
CYTH1Cytohesin-1 isoform X1. (410 aa)
LOC111182578ADP-ribosylation factor 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (231 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (243 aa)
DGKZDiacylglycerol kinase. (1210 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
PLD2Phospholipase. (933 aa)
RALARas-related protein Ral-A. (206 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLA2G4APhospholipase A2. (749 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1208 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
TSC2Tuberin isoform X8. (1815 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma. (376 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
CYTH4Cytohesin-4. (420 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (286 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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