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USP30 USP30 PINK1 PINK1 FOXO3 FOXO3 ATG5 ATG5 CSNK2A2 CSNK2A2 FUNDC1 FUNDC1 CALCOCO2 CALCOCO2 RRAS2 RRAS2 MAPK10 MAPK10 CITED2 CITED2 BECN1 BECN1 SQSTM1 SQSTM1 AGPAT4 AGPAT4 HRAS HRAS RAB7A RAB7A MAPK9 MAPK9 TFE3 TFE3 LOC111170713 LOC111170713 MAPK8 MAPK8 ATG9A ATG9A MFN1 MFN1 BNIP3 BNIP3 HIF1A HIF1A USP15 USP15 MITF MITF SP1 SP1 TBC1D15 TBC1D15 JUN JUN TBK1 TBK1 KRAS KRAS GABARAPL1 GABARAPL1 BCL2L13 BCL2L13 BECN2 BECN2 OPTN OPTN MRAS MRAS TFEB TFEB TBC1D17 TBC1D17 GABARAPL2 GABARAPL2 RRAS RRAS TAX1BP1 TAX1BP1 NRAS NRAS FIS1 FIS1 TOMM7 TOMM7 USP8 USP8 AMBRA1 AMBRA1 RELA RELA SRC SRC RAB7B RAB7B E2F1 E2F1 BNIP3L BNIP3L BCL2L1 BCL2L1 CSNK2A1 CSNK2A1 ATF4 ATF4 RHOT1 RHOT1 RPS27A RPS27A RHOT2 RHOT2 EIF2AK3 EIF2AK3 GABARAP GABARAP ULK1 ULK1 PGAM5 PGAM5 MFN2 MFN2 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (519 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
FOXO3Forkhead box protein O3. (672 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
FUNDC1FUN14 domain-containing protein 1. (155 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2. (448 aa)
RRAS2Ras-related protein R-Ras2. (204 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
BECN1Beclin-1 isoform X5. (471 aa)
SQSTM1Sequestosome-1. (440 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TFE3Transcription factor E3 isoform X1. (575 aa)
LOC111170713Lymphocyte antigen 6 complex locus protein G5b isoform X2. (299 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
MFN1Mitofusin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (742 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (196 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
SP1Transcription factor Sp1. (786 aa)
TBC1D15TBC1 domain family member 15 isoform X1. (691 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
KRASGTPase KRas. (188 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
BCL2L13Bcl-2-like protein 13 isoform X1. (448 aa)
BECN2Beclin-2. (432 aa)
OPTNOptineurin isoform X1. (567 aa)
MRASRas-related protein M-Ras. (208 aa)
TFEBTranscription factor EB isoform X1. (472 aa)
TBC1D17TBC1 domain family member 17 isoform X1. (655 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1. (117 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
TAX1BP1Tax1-binding protein 1 isoform X1. (842 aa)
NRASGTPase NRas. (189 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
TOMM7Mitochondrial import receptor subunit TOM7 homolog isoform X1. (55 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1087 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SRCTyrosine-protein kinase. (562 aa)
RAB7BRas-related protein Rab-7b isoform X1. (210 aa)
E2F1Transcription factor E2F1. (437 aa)
BNIP3LBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1. (218 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (644 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1155 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1055 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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