STRINGSTRING
ADIPOQ ADIPOQ ACACB ACACB RPS6KB1 RPS6KB1 MAP3K7 MAP3K7 PCK2 PCK2 FOXO3 FOXO3 ACACA ACACA LOC111164621 LOC111164621 INSR INSR IRS4 IRS4 PFKP PFKP RAB11B RAB11B EEF2 EEF2 G6PC G6PC PIK3R2 PIK3R2 LOC111164620 LOC111164620 FBP2 FBP2 CRTC2 CRTC2 CREB3L4 CREB3L4 ELAVL1 ELAVL1 FBP1 FBP1 PPP2R1B PPP2R1B CREB3L3 CREB3L3 LOC111168952 LOC111168952 RAB8A RAB8A SREBF1 SREBF1 PFKFB1 PFKFB1 G6PC3 G6PC3 PPP2R3B PPP2R3B ADIPOR1 ADIPOR1 STRADB STRADB IRS1 IRS1 PPP2R2D PPP2R2D SCD SCD CAB39 CAB39 PPARGC1A PPARGC1A G6PC2 G6PC2 PPP2R3C PPP2R3C CREB1 CREB1 STK11 STK11 PPP2CB PPP2CB EIF4EBP1 EIF4EBP1 PRKAG3 PRKAG3 PIK3CA PIK3CA PRKAG1 PRKAG1 PFKM PFKM PFKFB4 PFKFB4 PPP2R5E PPP2R5E FOXO1 FOXO1 CAB39L CAB39L PIK3R3 PIK3R3 AKT1 AKT1 CCNA1 CCNA1 IRS2 IRS2 RHEB RHEB PRKAG2 PRKAG2 PRKAA2 PRKAA2 AKT3 AKT3 RAB10 RAB10 TSC1 TSC1 ADIPOR2 ADIPOR2 GYS2 GYS2 LEPR LEPR PFKFB3 PFKFB3 RAB14 RAB14 PPP2R5D PPP2R5D MLYCD MLYCD CREB3L2 CREB3L2 PIK3CB PIK3CB CFTR CFTR GYS1 GYS1 PPP2R2C PPP2R2C PPP2R3A PPP2R3A LIPE LIPE PRKAB2 PRKAB2 PPP2R1A PPP2R1A CREB5 CREB5 FASN FASN AKT2 AKT2 AKT1S1 AKT1S1 CPT1C CPT1C STRADA STRADA PPP2CA PPP2CA RPTOR RPTOR CPT1A CPT1A RPS6KB2 RPS6KB2 PPP2R5B PPP2R5B LOC111181964 LOC111181964 SIRT1 SIRT1 EEF2K EEF2K CCND1 CCND1 CREB3L1 CREB3L1 PPP2R5A PPP2R5A PPP2R2B PPP2R2B PFKFB2 PFKFB2 INS INS ADRA1A ADRA1A HNF4A HNF4A CCNA2 CCNA2 HMGCR HMGCR CPT1B CPT1B SLC2A4 SLC2A4 TSC2 TSC2 PDPK1 PDPK1 PFKL PFKL PPP2R2A PPP2R2A RAB2A RAB2A ULK1 ULK1 CAMKK2 CAMKK2 PIK3R1 PIK3R1 PRKAA1 PRKAA1 MTOR MTOR IGF1R IGF1R SCD5 SCD5 PCK1 PCK1 IGF1 IGF1 PRKAB1 PRKAB1 PIK3CD PIK3CD CREB3 CREB3 Ob Ob
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (2456 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (655 aa)
FOXO3Forkhead box protein O3. (672 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2383 aa)
LOC111164621Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (809 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
EEF2Elongation factor 2. (858 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111164620Platelet glycoprotein 4-like; Belongs to the CD36 family. (472 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X1. (701 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
FBP1Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (338 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC111168952Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (933 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1213 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1. (471 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (578 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
SCDacyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
CAB39Calcium-binding protein 39. (341 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1. (520 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
FOXO1Forkhead box protein O1. (663 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
RHEBGTP-binding protein Rheb. (184 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RAB10Ras-related protein Rab-10. (200 aa)
TSC1Hamartin. (1169 aa)
ADIPOR2Adiponectin receptor protein 2 isoform X1. (386 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
LEPRLeptin receptor isoform X1. (917 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (526 aa)
RAB14Ras-related protein Rab-14. (215 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
LIPEHormone-sensitive lipase isoform X1. (799 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
FASNFatty acid synthase isoform X1. (2680 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (325 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform isoform X1. (836 aa)
STRADASTE20-related kinase adapter protein alpha isoform X1. (431 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RPTORRegulatory-associated protein of mTOR isoform X7. (1335 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
EEF2KEukaryotic elongation factor 2 kinase. (722 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1. (554 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (484 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (780 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TSC2Tuberin isoform X8. (1815 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
RAB2ARas-related protein Rab-2A isoform X1. (226 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1055 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
SCD5stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (334 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
ObLeptin isoform X1. (167 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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