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| | LOC111163074 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (415 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | SEPT4 | Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (487 aa) |
| | BCL2A1 | Bcl-2-related protein A1. (175 aa) |
| | CTSH | Pro-cathepsin H; Belongs to the peptidase C1 family. (335 aa) |
| | LOC111162959 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | LOC111164169 | LOW QUALITY PROTEIN: mast cell protease 3-like; Belongs to the peptidase S1 family. (261 aa) |
| | LOC111164234 | Granzyme B-like isoform X1; Belongs to the peptidase S1 family. (248 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | LOC111166812 | Cathepsin L1; Belongs to the peptidase C1 family. (334 aa) |
| | LMNA | Lamin; Belongs to the intermediate filament family. (664 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (795 aa) |
| | CTSL | Cathepsin L1; Belongs to the peptidase C1 family. (333 aa) |
| | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | BIRC3 | Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | XIAP | E3 ubiquitin-protein ligase XIAP isoform X1. (497 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa) |
| | SPTA1 | Spectrin alpha chain, erythrocytic 1 isoform X1. (2417 aa) |
| | AIFM1 | Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa) |
| | PTPN13 | Tyrosine-protein phosphatase non-receptor type 13 isoform X1. (2520 aa) |
| | HTRA2 | Serine protease HTRA2, mitochondrial. (458 aa) |
| | CTSK | Cathepsin K isoform X1; Belongs to the peptidase C1 family. (358 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (340 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa) |
| | LOC111168369 | Baculoviral IAP repeat-containing protein 2. (620 aa) |
| | LOC111170121 | Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (286 aa) |
| | ACTB | Actin, cytoplasmic 1. (375 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa) |
| | CTSD | Cathepsin D; Belongs to the peptidase A1 family. (411 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta. (160 aa) |
| | IL3RA | Interleukin-3 receptor subunit alpha isoform X1. (473 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa) |
| | CASP10 | Caspase-10; Belongs to the peptidase C14A family. (518 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC111171851 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (425 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | CASP8 | Caspase-8; Belongs to the peptidase C14A family. (486 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa) |
| | LMNB2 | lamin-B2 isoform X1; Belongs to the intermediate filament family. (627 aa) |
| | IKBKG | NF-kappa-B essential modulator isoform X1. (412 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1. (315 aa) |
| | PIDD1 | P53-induced death domain-containing protein 1 isoform X1. (971 aa) |
| | CASP6 | Caspase-6 isoform X1; Belongs to the peptidase C14A family. (294 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa) |
| | CASP3 | Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (288 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | TUBA4A | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (586 aa) |
| | LOC111174575 | Cytochrome c-like. (69 aa) |
| | CASP7 | Caspase-7; Belongs to the peptidase C14A family. (301 aa) |
| | LOC111174050 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa) |
| | LOC111172911 | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (314 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (343 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | KRAS | GTPase KRas. (188 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa) |
| | LOC111174031 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | LOC111174051 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa) |
| | LOC111174197 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa) |
| | FOS | Proto-oncogene c-Fos. (380 aa) |
| | TUBA8 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (496 aa) |
| | CAPN2 | Calpain-2 catalytic subunit isoform X1; Belongs to the peptidase C2 family. (703 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | LOC111175930 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | CASP2 | Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer isoform X1. (239 aa) |
| | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa) |
| | TRAF1 | TNF receptor-associated factor. (415 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | ENDOG | Endonuclease. (300 aa) |
| | SPTAN1 | Spectrin alpha chain, non-erythrocytic 1 isoform X1. (2477 aa) |
| | DAB2IP | Disabled homolog 2-interacting protein isoform X1. (1193 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa) |
| | CTSO | Cathepsin O isoform X2; Belongs to the peptidase C1 family. (328 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | DAXX | Death domain-associated protein 6 isoform X1. (742 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (223 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (233 aa) |
| | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa) |
| | NGF | Beta-nerve growth factor; Belongs to the NGF-beta family. (241 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | LOC111180543 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LMNB1 | lamin-B1; Belongs to the intermediate filament family. (586 aa) |
| | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | BBC3 | Bcl-2-binding component 3. (193 aa) |
| | ACTG1 | Actin, cytoplasmic 2. (375 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5. (142 aa) |
| | CAPN1 | Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (716 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (563 aa) |
| | PRF1 | Perforin-1. (555 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | CTSC | Dipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family. (463 aa) |
| | CTSF | LOW QUALITY PROTEIN: cathepsin F; Belongs to the peptidase C1 family. (491 aa) |
| | CTSW | Cathepsin W isoform X1; Belongs to the peptidase C1 family. (386 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | BCL2L1 | Bcl-2-like protein 1 isoform X1. (233 aa) |
| | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa) |
| | CTSB | Cathepsin B isoform X1; Belongs to the peptidase C1 family. (334 aa) |
| | CSF2RB | Cytokine receptor common subunit beta. (902 aa) |
| | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa) |
| | CASP9 | Caspase-9; Belongs to the peptidase C14A family. (452 aa) |
| | LOC111185435 | Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa) |
| | LOC111185436 | Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa) |
| | DFFB | DNAation factor subunit beta. (341 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1155 aa) |
| | CTSZ | Cathepsin Z; Belongs to the peptidase C1 family. (303 aa) |
| | BCL2L11 | Bcl-2-like protein 11 isoform X1. (288 aa) |
| | HRK | Activator of apoptosis harakiri. (91 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | DIABLO | Diablo homolog, mitochondrial isoform X1. (237 aa) |
| | DFFA | DNAation factor subunit alpha isoform X1. (380 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
