STRINGSTRING
ADIPOQ ADIPOQ SESN2 SESN2 RPS6KB1 RPS6KB1 ADCY4 ADCY4 ADCY8 ADCY8 FOXO3 FOXO3 ADCY7 ADCY7 ATG5 ATG5 INSR INSR IRS4 IRS4 RB1CC1 RB1CC1 SESN1 SESN1 PIK3R2 PIK3R2 PRKACA PRKACA CREB3L4 CREB3L4 SOD2 SOD2 CREB3L3 CREB3L3 LOC111168952 LOC111168952 SESN3 SESN3 HRAS HRAS EHMT2 EHMT2 ATF6B ATF6B ADIPOR1 ADIPOR1 IRS1 IRS1 ADCY5 ADCY5 PPARGC1A PPARGC1A CREB1 CREB1 STK11 STK11 EIF4EBP1 EIF4EBP1 PRKAG3 PRKAG3 PIK3CA PIK3CA PRKAG1 PRKAG1 APPL1 APPL1 EIF4E2 EIF4E2 ADCY3 ADCY3 FOXO1 FOXO1 ATF2 ATF2 PIK3R3 PIK3R3 AKT1 AKT1 IRS2 IRS2 RHEB RHEB ATG101 ATG101 KRAS KRAS ADCY6 ADCY6 KL KL PRKAG2 PRKAG2 PRKAA2 PRKAA2 AKT3 AKT3 EHMT1 EHMT1 TSC1 TSC1 ADIPOR2 ADIPOR2 PRKACB PRKACB EIF4E EIF4E CAT CAT CREB3L2 CREB3L2 PIK3CB PIK3CB NFKB1 NFKB1 ADCY2 ADCY2 BAX BAX PRKAB2 PRKAB2 CREB5 CREB5 NRAS NRAS AKT2 AKT2 AKT1S1 AKT1S1 RPTOR RPTOR RPS6KB2 RPS6KB2 LOC111181964 LOC111181964 SIRT1 SIRT1 RELA RELA CREB3L1 CREB3L1 ADCY1 ADCY1 INS INS ATG13 ATG13 ATF4 ATF4 TSC2 TSC2 ADCY9 ADCY9 ULK1 ULK1 CAMKK2 CAMKK2 PIK3R1 PIK3R1 PRKAA1 PRKAA1 MTOR MTOR IGF1R IGF1R IGF1 IGF1 PRKAB1 PRKAB1 PIK3CD PIK3CD CREB3 CREB3 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
SESN2Sestrin-2. (471 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
FOXO3Forkhead box protein O3. (672 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1589 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC111168952Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (933 aa)
SESN3Sestrin-3 isoform X1. (499 aa)
HRASGTPase HRas isoform X1. (189 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (282 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
FOXO1Forkhead box protein O1. (663 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
RHEBGTP-binding protein Rheb. (184 aa)
ATG101Autophagy-related protein 101. (218 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
KLKlotho. (1010 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1 isoform X3. (1263 aa)
TSC1Hamartin. (1169 aa)
ADIPOR2Adiponectin receptor protein 2 isoform X1. (386 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X1; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (325 aa)
RPTORRegulatory-associated protein of mTOR isoform X7. (1335 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
RELATranscription factor p65 isoform X1. (562 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (551 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
TSC2Tuberin isoform X8. (1815 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1055 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.