STRINGSTRING
RPS6KB1 RPS6KB1 ADCY4 ADCY4 ADCY8 ADCY8 FOXO3 FOXO3 ADCY7 ADCY7 LOC111164829 LOC111164829 ATG5 ATG5 INSR INSR IRS4 IRS4 PIK3R2 PIK3R2 LOC111164824 LOC111164824 PRKACA PRKACA SOD2 SOD2 CRYAB CRYAB HSPA8 HSPA8 HRAS HRAS LOC111170664 LOC111170664 LOC111170662 LOC111170662 IRS1 IRS1 SOD1 SOD1 ADCY5 ADCY5 HSPA6 HSPA6 CLPB CLPB PRKAG3 PRKAG3 PIK3CA PIK3CA PRKAG1 PRKAG1 HSPA2 HSPA2 ADCY3 ADCY3 FOXO1 FOXO1 HDAC1 HDAC1 PIK3R3 PIK3R3 AKT1 AKT1 IRS2 IRS2 KRAS KRAS ADCY6 ADCY6 PRKAG2 PRKAG2 PRKAA2 PRKAA2 AKT3 AKT3 PRKACB PRKACB CAT CAT PIK3CB PIK3CB ADCY2 ADCY2 PRKAB2 PRKAB2 NRAS NRAS AKT2 AKT2 AKT1S1 AKT1S1 EIF4EBP2 EIF4EBP2 RPTOR RPTOR RPS6KB2 RPS6KB2 LOC111181964 LOC111181964 SIRT1 SIRT1 FOXA2 FOXA2 ADCY1 ADCY1 INS INS ADCY9 ADCY9 PIK3R1 PIK3R1 PRKAA1 PRKAA1 MTOR MTOR IGF1R IGF1R IGF1 IGF1 PRKAB1 PRKAB1 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
FOXO3Forkhead box protein O3. (672 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (650 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111170664Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC111170662Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (645 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (677 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
FOXO1Forkhead box protein O1. (663 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (325 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
RPTORRegulatory-associated protein of mTOR isoform X7. (1335 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
FOXA2Hepatocyte nuclear factor 3-beta isoform X1. (462 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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