STRINGSTRING
AGTR1 AGTR1 PLA2G3 PLA2G3 PLA2G2F PLA2G2F PLA2G5 PLA2G5 PLA2G10 PLA2G10 MAPK1 MAPK1 AGT AGT MYH11 MYH11 ADCY4 ADCY4 ADCY8 ADCY8 PLA2G2D PLA2G2D ADCY7 ADCY7 PLA2G1B PLA2G1B MYLK3 MYLK3 ADM ADM LOC111165271 LOC111165271 LOC111165279 LOC111165279 ADORA2A ADORA2A PLA2G2C PLA2G2C LOC111163294 LOC111163294 LOC111165254 LOC111165254 LOC111165269 LOC111165269 ROCK2 ROCK2 PLCB1 PLCB1 PLCB4 PLCB4 MAP2K2 MAP2K2 GNA11 GNA11 RAMP2 RAMP2 ARAF ARAF PRKACA PRKACA ARHGEF11 ARHGEF11 MRVI1 MRVI1 ADORA2B ADORA2B GUCY1A2 GUCY1A2 CACNA1S CACNA1S PPP1R12B PPP1R12B NPR1 NPR1 PPP1R12A PPP1R12A CACNA1F CACNA1F ARHGEF12 ARHGEF12 ADRA1B ADRA1B CALCRL CALCRL RAF1 RAF1 ADCY5 ADCY5 GNA12 GNA12 ACTA2 ACTA2 RAMP1 RAMP1 NPPC NPPC LOC111171379 LOC111171379 PLA2G12A PLA2G12A AVPR1A AVPR1A KCNMB4 KCNMB4 MYL6B MYL6B ITPR1 ITPR1 KCNMB2 KCNMB2 ADCY3 ADCY3 PRKCE PRKCE CACNA1D CACNA1D PRKG1 PRKG1 MYL6 MYL6 EDN2 EDN2 PRKCH PRKCH PPP1CB PPP1CB PRKCD PRKCD RHOA RHOA ITPR2 ITPR2 ADCY6 ADCY6 CACNA1C CACNA1C GNAQ GNAQ CALML4 CALML4 BRAF BRAF CALM1 CALM1 PRKCQ PRKCQ PRKACB PRKACB GUCY1A3 GUCY1A3 CALD1 CALD1 MAP2K1 MAP2K1 ITPR3 ITPR3 ADCY2 ADCY2 PPP1R14A PPP1R14A GUCY1B3 GUCY1B3 PTGIR PTGIR PLA2G4F PLA2G4F PLCB2 PLCB2 ROCK1 ROCK1 PLA2G4E PLA2G4E MAPK3 MAPK3 PPP1R12C PPP1R12C MYH14 MYH14 GNA13 GNA13 ARHGEF1 ARHGEF1 PRKCB PRKCB EDN1 EDN1 PRKCA PRKCA PPP1CA PPP1CA PLA2G12B PLA2G12B KCNMA1 KCNMA1 PLCB3 PLCB3 ADRA1D ADRA1D AVP AVP MYL9 MYL9 ADCY1 ADCY1 ADRA1A ADRA1A MYLK2 MYLK2 RAMP3 RAMP3 AVPR1B AVPR1B PLA2G4A PLA2G4A ADCY9 ADCY9 KCNMB1 KCNMB1 PPP1CC PPP1CC MYH10 MYH10 CALML6 CALML6 NPPB NPPB PLA2G6 PLA2G6 EDNRA EDNRA GNAS GNAS NPPA NPPA MYH9 MYH9 NPR2 NPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
PLA2G2FPhospholipase A(2). (300 aa)
PLA2G5Phospholipase A(2). (156 aa)
PLA2G10Phospholipase A(2). (159 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PLA2G2DPhospholipase A(2). (161 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PLA2G1BPhospholipase A(2). (160 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADMADM. (188 aa)
LOC111165271Calcitonin receptor-stimulating peptide 1-like. (127 aa)
LOC111165279Calcitonin receptor-stimulating peptide 2-like. (125 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
PLA2G2CPutative inactive group IIC secretory phospholipase A2. (107 aa)
LOC111163294Phospholipase A(2). (116 aa)
LOC111165254Calcitonin isoform X1. (138 aa)
LOC111165269Calcitonin gene-related peptide 2-like isoform X1. (131 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11 isoform X1. (1576 aa)
MRVI1Protein MRVI1 isoform X1. (902 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (726 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (994 aa)
NPR1Guanylate cyclase. (1065 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa)
ADRA1Balpha-1B adrenergic receptor. (518 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X2. (279 aa)
ACTA2Actin, aortic smooth muscle. (466 aa)
RAMP1Receptor activity-modifying protein 1. (148 aa)
NPPCC-type natriuretic peptide. (126 aa)
LOC111171379Cytochrome P450 4A4-like isoform X1. (181 aa)
PLA2G12AGroup XIIA secretory phospholipase A2. (189 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
MYL6BMyosin light chain 6B. (213 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
PRKCEProtein kinase C. (746 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
MYL6Myosin light polypeptide 6 isoform X2. (151 aa)
EDN2Endothelin-2. (147 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
RHOATransforming protein RhoA. (193 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PRKCQProtein kinase C. (665 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
CALD1Caldesmon isoform X1. (798 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A. (147 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PLA2G4FPhospholipase A2. (849 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PLA2G4EPhospholipase A2. (868 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (806 aa)
MYH14Myosin-14 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (998 aa)
PRKCBProtein kinase C. (689 aa)
EDN1Endothelin-1. (202 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (195 aa)
KCNMA1LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1. (1320 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ADRA1Dalpha-1D adrenergic receptor isoform X1. (569 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
PLA2G4APhospholipase A2. (749 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MYH10Myosin-10 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2023 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
NPPBNatriuretic peptides B. (132 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (835 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
NPPANatriuretic peptides A. (152 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
NPR2Guanylate cyclase. (1056 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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