STRINGSTRING
CDC42 CDC42 MAPK1 MAPK1 MAP2K2 MAP2K2 PIK3R2 PIK3R2 SH2D2A SH2D2A HRAS HRAS RAF1 RAF1 PPP3CC PPP3CC KDR KDR SHC2 SHC2 PIK3CA PIK3CA PIK3R3 PIK3R3 MAPKAPK3 MAPKAPK3 AKT1 AKT1 NOS3 NOS3 KRAS KRAS AKT3 AKT3 MAPK14 MAPK14 VEGFA VEGFA MAPK13 MAPK13 PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 PPP3CA PPP3CA PLA2G4F PLA2G4F NRAS NRAS PLA2G4E PLA2G4E RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 SPHK2 SPHK2 HSPB1 HSPB1 PRKCB PRKCB PRKCA PRKCA SPHK1 SPHK1 RAC1 RAC1 PLCG1 PLCG1 PPP3CB PPP3CB SRC SRC MAPKAPK2 MAPKAPK2 BAD BAD RAC2 RAC2 PTGS2 PTGS2 PLA2G4A PLA2G4A CASP9 CASP9 MAPK12 MAPK12 PIK3R1 PIK3R1 MAPK11 MAPK11 PPP3R1 PPP3R1 NFATC2 NFATC2 PPP3R2 PPP3R2 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SH2D2ASH2 domain-containing protein 2A isoform X1. (449 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PLA2G4FPhospholipase A2. (849 aa)
NRASGTPase NRas. (189 aa)
PLA2G4EPhospholipase A2. (868 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
SPHK1Sphingosine kinase 1 isoform X2. (484 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SRCTyrosine-protein kinase. (562 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
BADBcl2-associated agonist of cell death. (168 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PLA2G4APhospholipase A2. (749 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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