STRINGSTRING
AGTR1 AGTR1 GNGT2 GNGT2 MAPK1 MAPK1 SLC9A1 SLC9A1 GNG4 GNG4 RPS6KB1 RPS6KB1 ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 MYLK3 MYLK3 PLCB1 PLCB1 GNAI1 GNAI1 PIK3CG PIK3CG CTGF CTGF PLCB4 PLCB4 RYR2 RYR2 MAP2K2 MAP2K2 RRAS2 RRAS2 KLF2 KLF2 GNG14 GNG14 PRKACA PRKACA MEF2D MEF2D PDE3B PDE3B LOC111166538 LOC111166538 JAG1 JAG1 LOC111168030 LOC111168030 PIK3R4 PIK3R4 BECN1 BECN1 NOTCH3 NOTCH3 PIK3C3 PIK3C3 PLIN1 PLIN1 ADCY10 ADCY10 HDAC5 HDAC5 HRAS HRAS RAF1 RAF1 ADCY5 ADCY5 ACTA2 ACTA2 TFAM TFAM GNG7 GNG7 PPARGC1A PPARGC1A SLC8A3 SLC8A3 PLAT PLAT HDAC4 HDAC4 PRKAG3 PRKAG3 PRKAG1 PRKAG1 ITPR1 ITPR1 GNB4 GNB4 GNAI2 GNAI2 ADCY3 ADCY3 PRKCE PRKCE GNG2 GNG2 AKT1 AKT1 NOS3 NOS3 KRAS KRAS ITPR2 ITPR2 ADCY6 ADCY6 GABARAPL1 GABARAPL1 MYL3 MYL3 GNAQ GNAQ PRKAG2 PRKAG2 PRKAA2 PRKAA2 AKT3 AKT3 RPS6 RPS6 SLC8A1 SLC8A1 CALML4 CALML4 LOC111176690 LOC111176690 BECN2 BECN2 GNB5 GNB5 LOC111178792 LOC111178792 CALM1 CALM1 MRAS MRAS LOC111177332 LOC111177332 PRKACB PRKACB SMAD3 SMAD3 SMAD4 SMAD4 SMAD2 SMAD2 MAP2K1 MAP2K1 NRF1 NRF1 ITPR3 ITPR3 RYR1 RYR1 GNG5 GNG5 GNG12 GNG12 SPP1 SPP1 ADCY2 ADCY2 GABARAPL2 GABARAPL2 RRAS RRAS GNG11 GNG11 LIPE LIPE PRKAB2 PRKAB2 CDH1 CDH1 PLCB2 PLCB2 RYR3 RYR3 NRAS NRAS GNAI3 GNAI3 EGR1 EGR1 MYL4 MYL4 AKT2 AKT2 MAPK3 MAPK3 SPHK2 SPHK2 SLC8A2 SLC8A2 GNB2 GNB2 GNG8 GNG8 GNA13 GNA13 GNGT1 GNGT1 SPHK1 SPHK1 RPS6KB2 RPS6KB2 SERPINE1 SERPINE1 CCND1 CCND1 PLCB3 PLCB3 GNG13 GNG13 ADCY1 ADCY1 GNG3 GNG3 APLNR APLNR MYLK2 MYLK2 LOC111185989 LOC111185989 ADCY9 ADCY9 GABARAP GABARAP MYL2 MYL2 PIK3R5 PIK3R5 PIK3R6 PIK3R6 PRKAA1 PRKAA1 CALML6 CALML6 MTOR MTOR MEF2A MEF2A NOS1 NOS1 PRKAB1 PRKAB1 TGFBR1 TGFBR1 GNB1 GNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
CTGFConnective tissue growth factor isoform X1. (349 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
RYR2Ryanodine receptor 2 isoform X1. (4965 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
RRAS2Ras-related protein R-Ras2. (204 aa)
KLF2Krueppel-like factor 2. (355 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (101 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MEF2DMyocyte-specific enhancer factor 2D isoform X1. (512 aa)
PDE3BPhosphodiesterase. (1120 aa)
LOC111166538Myocyte-specific enhancer factor 2B-like isoform X1. (499 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
LOC111168030Apelin. (77 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
BECN1Beclin-1 isoform X5. (471 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2336 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PLIN1Perilipin; Belongs to the perilipin family. (517 aa)
ADCY10Adenylate cyclase type 10. (1614 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ACTA2Actin, aortic smooth muscle. (466 aa)
TFAMTranscription factor A, mitochondrial. (240 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
PRKCEProtein kinase C. (746 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
MYL3Myosin light chain 3. (199 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (267 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X7; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1004 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
LOC111176690Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
BECN2Beclin-2. (432 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa)
LOC111178792LOW QUALITY PROTEIN: adenylate cyclase type 10-like. (1611 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
MRASRas-related protein M-Ras. (208 aa)
LOC111177332Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRF1Nuclear respiratory factor 1 isoform X1. (517 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
RYR1LOW QUALITY PROTEIN: ryanodine receptor 1. (5030 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
SPP1Osteopontin. (362 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1. (117 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LIPEHormone-sensitive lipase isoform X1. (799 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
RYR3Ryanodine receptor 3 isoform X1. (4869 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
MYL4Myosin light chain 4 isoform X1. (194 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SPHK1Sphingosine kinase 1 isoform X2. (484 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (501 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1461 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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