Your Input: | |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | IFNAR1 | Interferon alpha/beta receptor 1 isoform X1. (561 aa) |
| | IFNAR2 | Interferon alpha/beta receptor 2 isoform X1. (594 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (364 aa) |
| | IRF9 | LOW QUALITY PROTEIN: interferon regulatory factor 9. (479 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa) |
| | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (953 aa) |
| | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa) |
| | TYK2 | Tyrosine-protein kinase. (1188 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (469 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (349 aa) |
| | JUNB | Transcription factor jun-B. (347 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa) |
| | TNFRSF11B | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | LOC111168952 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (933 aa) |
| | JUND | Transcription factor jun-D. (345 aa) |
| | SQSTM1 | Sequestosome-1. (440 aa) |
| | CTSK | Cathepsin K isoform X1; Belongs to the peptidase C1 family. (358 aa) |
| | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa) |
| | SYK | Tyrosine-protein kinase. (626 aa) |
| | TEC | Tyrosine-protein kinase. (658 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (522 aa) |
| | STAT1 | Signal transducer and activator of transcription. (749 aa) |
| | LOC111170413 | Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa) |
| | IKBKG | NF-kappa-B essential modulator isoform X1. (412 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa) |
| | STAT2 | Signal transducer and activator of transcription. (911 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa) |
| | MITF | Microphthalmia-associated transcription factor isoform X1. (526 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | IFNB1 | Interferon beta. (185 aa) |
| | NFKB2 | Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa) |
| | BLNK | B-cell linker protein isoform X1. (528 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (314 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (343 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | FOS | Proto-oncogene c-Fos. (380 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | FOSL2 | Fos-related antigen 2 isoform X1. (327 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | LCK | Tyrosine-protein kinase. (509 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BTK | Tyrosine-protein kinase. (687 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | LOC111179403 | Cytochrome b-245 light chain isoform X1. (202 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (294 aa) |
| | NOX1 | LOW QUALITY PROTEIN: NADPH oxidase 1. (567 aa) |
| | JAK1 | Tyrosine-protein kinase. (1153 aa) |
| | TNFRSF11A | Tumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa) |
| | FOSB | Protein fosB isoform X1. (341 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | NCF1 | Neutrophil cytosol factor 1 isoform X2. (405 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | CALCR | Calcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (524 aa) |
| | TYROBP | TYRO protein tyrosine kinase-binding protein isoform X1. (126 aa) |
| | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (237 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (192 aa) |
| | LOC111183965 | Transcription factor PU.1-like. (213 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | LOC111184361 | Signal-regulatory protein beta-1-like isoform X1. (412 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | NCF2 | Neutrophil cytosol factor 2 isoform X1. (526 aa) |
| | LOC111183964 | Transcription factor PU.1 isoform X1. (271 aa) |
| | CSF1R | Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa) |
| | FOSL1 | Fos-related antigen 1. (271 aa) |
| | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1. (504 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa) |
| | GAB2 | GRB2-associated-binding protein 2 isoform X1. (678 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (456 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2 isoform X1. (534 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (265 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | LOC111186386 | Neutrophil cytosol factor 4-like. (250 aa) |
| | PPP3R1 | Calcineurin subunit B type 1. (170 aa) |
| | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa) |
| | LOC111187847 | Neutrophil cytosol factor 4 isoform X2. (339 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | PPP3R2 | LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | IL1R1 | Interleukin-1 receptor type 1 isoform X1. (686 aa) |
| | FHL2 | Four and a half LIM domains protein 2. (279 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
