STRINGSTRING
WNT4 WNT4 NF2 NF2 AJUBA AJUBA MYC MYC ID2 ID2 TGFBR2 TGFBR2 YWHAQ YWHAQ YWHAH YWHAH AMOT AMOT CTGF CTGF NKD1 NKD1 AMH AMH TCF7L1 TCF7L1 CTNNA2 CTNNA2 LATS1 LATS1 BMP2 BMP2 SNAI2 SNAI2 TEAD1 TEAD1 PARD6G PARD6G LLGL1 LLGL1 PPP2R1B PPP2R1B BIRC3 BIRC3 BMPR1A BMPR1A WNT7A WNT7A CTNNB1 CTNNB1 WNT3A WNT3A MOB1A MOB1A GSK3B GSK3B LOC111168369 LOC111168369 ACTB ACTB GLI2 GLI2 DLG3 DLG3 FRMD1 FRMD1 YAP1 YAP1 LEF1 LEF1 BMPR2 BMPR2 FZD5 FZD5 WNT10A WNT10A FZD2 FZD2 WNT9A WNT9A PPP2R2D PPP2R2D DLG1 DLG1 BTRC BTRC BMP4 BMP4 PPP2CB PPP2CB MPP5 MPP5 TCF7L2 TCF7L2 FRMD6 FRMD6 SAV1 SAV1 FZD7 FZD7 WNT6 WNT6 LIMD1 LIMD1 PRKCI PRKCI GDF7 GDF7 LATS2 LATS2 WNT5A WNT5A LOC111175442 LOC111175442 WNT10B WNT10B PPP1CB PPP1CB RASSF1 RASSF1 DVL3 DVL3 WNT1 WNT1 CCND2 CCND2 CRB2 CRB2 BMP8A BMP8A BMP8B BMP8B WNT5B WNT5B PATJ PATJ TGFB2 TGFB2 PARD3 PARD3 FZD8 FZD8 CRB1 CRB1 TEAD3 TEAD3 CCND3 CCND3 TGFB3 TGFB3 LOC111178986 LOC111178986 BMP5 BMP5 LOC111179149 LOC111179149 SMAD3 SMAD3 WWTR1 WWTR1 TP53BP2 TP53BP2 SMAD4 SMAD4 SMAD2 SMAD2 GDF6 GDF6 WNT2B WNT2B FZD1 FZD1 WNT2 WNT2 FZD6 FZD6 TGFB1 TGFB1 BMP6 BMP6 BMPR1B BMPR1B WNT16 WNT16 PPP2R2C PPP2R2C WTIP WTIP PPP2R1A PPP2R1A CDH1 CDH1 PARD6A PARD6A YWHAZ YWHAZ FZD9 FZD9 TEAD2 TEAD2 TCF7 TCF7 SMAD7 SMAD7 STK3 STK3 BBC3 BBC3 CTNNA1 CTNNA1 WNT8A WNT8A WNT3 WNT3 PPP2CA PPP2CA ACTG1 ACTG1 BIRC5 BIRC5 LLGL2 LLGL2 PPP1CA PPP1CA AXIN2 AXIN2 CTNNA3 CTNNA3 YWHAG YWHAG SERPINE1 SERPINE1 CCND1 CCND1 APC APC CSNK1D CSNK1D ID1 ID1 FGF1 FGF1 PPP2R2B PPP2R2B WNT11 WNT11 DLG5 DLG5 DLG2 DLG2 FZD4 FZD4 YWHAB YWHAB AXIN1 AXIN1 FZD3 FZD3 GDF5 GDF5 DLG4 DLG4 LOC111186244 LOC111186244 PPP2R2A PPP2R2A WNT7B WNT7B FBXW11 FBXW11 WWC1 WWC1 DVL2 DVL2 PARD6B PARD6B YWHAE YWHAE PPP1CC PPP1CC AREG AREG FZD10 FZD10 TP73 TP73 DVL1 DVL1 PRKCZ PRKCZ ITGB2 ITGB2 MOB1B MOB1B RASSF6 RASSF6 BMP7 BMP7 SMAD1 SMAD1 TGFBR1 TGFBR1 AFP AFP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
NF2Merlin isoform X3. (619 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (557 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
AMOTAngiomotin isoform X1. (1081 aa)
CTGFConnective tissue growth factor isoform X1. (349 aa)
NKD1Protein naked cuticle homolog 1. (471 aa)
AMHMuellerian-inhibiting factor. (578 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
CTNNA2Catenin alpha-2. (865 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X3. (523 aa)
PARD6GPartitioning defective 6 homolog gamma. (371 aa)
LLGL1Lethal(2) giant larvae protein homolog 1 isoform X1. (1063 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MOB1AMOB kinase activator 1A. (216 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC111168369Baculoviral IAP repeat-containing protein 2. (620 aa)
ACTBActin, cytoplasmic 1. (375 aa)
GLI2Zinc finger protein GLI2. (1557 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (849 aa)
FRMD1FERM domain-containing protein 1 isoform X1. (551 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
FRMD6FERM domain-containing protein 6 isoform X1. (622 aa)
SAV1Protein salvador homolog 1. (385 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LIMD1LIM domain-containing protein 1. (669 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
GDF7Growth/differentiation factor 7. (449 aa)
LATS2Serine/threonine-protein kinase LATS2. (1043 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
LOC11117544214-3-3 protein gamma-like; Belongs to the 14-3-3 family. (153 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (340 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
CRB2Protein crumbs homolog 2. (1281 aa)
BMP8ABone morphogenetic protein 8A. (403 aa)
BMP8BLOW QUALITY PROTEIN: bone morphogenetic protein 8B. (403 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PATJinaD-like protein isoform X1. (1900 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1457 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (460 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
LOC11117914914-3-3 protein gamma-like; Belongs to the 14-3-3 family. (246 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2. (1136 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GDF6Growth/differentiation factor 6. (461 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
WTIPWilms tumor protein 1-interacting protein isoform X1. (434 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X3. (239 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
BBC3Bcl-2-binding component 3. (193 aa)
CTNNA1Catenin alpha-1. (906 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
LLGL2Lethal(2) giant larvae protein homolog 2 isoform X1. (1057 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
AXIN2Axin-2 isoform X1. (843 aa)
CTNNA3Catenin alpha-3. (944 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
CSNK1DCasein kinase I isoform X4; Belongs to the protein kinase superfamily. (428 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
AXIN1Axin-1 isoform X1. (866 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
GDF5Growth/differentiation factor 5. (499 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (752 aa)
LOC111186244Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
WWC1Protein KIBRA. (1109 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
AREGAmphiregulin isoform X1. (254 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
ITGB2Integrin beta. (769 aa)
MOB1BMOB kinase activator 1B isoform X1. (216 aa)
RASSF6Ras association domain-containing protein 6 isoform X3. (337 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
AFPAlpha-fetoprotein. (585 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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